Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe

Discoidin domain receptors 1 and 2 (DDR1/2) play a central role in fibrotic disorders, such as renal and pulmonary fibrosis, atherosclerosis, and various forms of cancer. Potent and selective inhibitors, so-called chemical probe compounds, have been developed to study DDR1/2 kinase signaling. Howeve...

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Veröffentlicht in:	Journal of medicinal chemistry 2021-09, Vol.64 (18), p.13451-13474
Hauptverfasser:	Röhm, Sandra, Berger, Benedict-Tilman, Schröder, Martin, Chatterjee, Deep, Mathea, Sebastian, Joerger, Andreas C, Pinkas, Daniel M, Bufton, Joshua C, Tjaden, Amelie, Kovooru, Lohitesh, Kudolo, Mark, Pohl, Christian, Bullock, Alex N, Müller, Susanne, Laufer, Stefan, Knapp, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Site Animals Benzamides - chemical synthesis Benzamides - metabolism Benzamides - pharmacology Cell Line, Tumor Discoidin Domain Receptor 1 - chemistry Discoidin Domain Receptor 1 - metabolism Discoidin Domain Receptor 2 - chemistry Discoidin Domain Receptor 2 - metabolism Dogs HEK293 Cells Humans Madin Darby Canine Kidney Cells Microsomes, Liver - metabolism p38 Mitogen-Activated Protein Kinases - chemistry p38 Mitogen-Activated Protein Kinases - metabolism Protein Binding Sulfonamides - chemical synthesis Sulfonamides - metabolism Sulfonamides - pharmacology
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