Triadimefon suppresses fetal adrenal gland development after in utero exposure

Illustration of the signaling pathway to regulate adrenal cortex development after triadimefon (TDM) exposure. TDM increases the generation of ROS to cause the following actions: 1) down-regulating IGF1, which can activate AKT1 signaling for the growth of the adrenal gland; 2) down-regulating AT1R a...

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Veröffentlicht in:	Toxicology (Amsterdam) 2021-10, Vol.462, p.152932-152932, Article 152932
Hauptverfasser:	Xu, Qiang, Chen, Quanxu, Lin, Liben, Zhang, Pu, Li, Zengqiang, Yu, Yige, Ma, Feifei, Ying, Yingfen, Li, Xiaoheng, Ge, Ren-Shan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex - drug effects Adrenal Cortex - embryology Adrenal development Adrenal Glands - drug effects Adrenal Glands - embryology Animals Antioxidants Antioxidants - metabolism Dose-Response Relationship, Drug Endocrine Disruptors - administration & dosage Endocrine Disruptors - toxicity Female Fungicide Fungicides, Industrial - administration & dosage Fungicides, Industrial - toxicity Male Maternal Exposure - adverse effects Phosphorylation - drug effects Pregnancy Rats Rats, Sprague-Dawley Steroidogenesis Triadimefon Triazoles - administration & dosage Triazoles - toxicity
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