Canadian ROS proto-oncogene 1 study (CROS) for multi-institutional implementation of ROS1 testing in non-small cell lung cancer

•High quality ROS1 IHC assays have high clinical utility.•Adjusting readout can increase diagnostic accuracy in ROS1 IHC.•ROS1 IHC readout must be balanced with the analytical sensitivity of the assay.•A multi-institutional approach abets the validation of rare disease biomarker assays. Patients wit...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2021-10, Vol.160, p.127-135
Hauptverfasser:	Cheung, Carol C., Smith, Adam C., Albadine, Roula, Bigras, Gilbert, Bojarski, Anna, Couture, Christian, Cutz, Jean-Claude, Huang, Weei-Yuan, Ionescu, Diana, Itani, Doha, Izevbaye, Iyare, Karsan, Aly, Kelly, Margaret M., Knoll, Joan, Kwan, Keith, Nasr, Michel R., Qing, Gefei, Rashid-Kolvear, Fariboz, Sekhon, Harmanjatinder S., Spatz, Alan, Stockley, Tracy, Tran-Thanh, Danh, Tucker, Tracy, Waghray, Ranjit, Wang, Hangjun, Xu, Zhaolin, Yatabe, Yasushi, Torlakovic, Emina E., Tsao, Ming-Sound
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarker testing FISH Immunohistochemistry Non-small cell lung cancer Quality assurance ROS1
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