Glucocorticoids regulate mitochondrial fatty acid oxidation in fetal cardiomyocytes

The late gestational rise in glucocorticoids contributes to the structural and functional maturation of the perinatal heart. Here, we hypothesized that glucocorticoid action contributes to the metabolic switch in perinatal cardiomyocytes from carbohydrate to fatty acid oxidation. In primary mouse fe...

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Veröffentlicht in:	The Journal of physiology 2021-11, Vol.599 (21), p.4901-4924
Hauptverfasser:	Ivy, Jessica R., Carter, Roderic N., Zhao, Jin‐Feng, Buckley, Charlotte, Urquijo, Helena, Rog‐Zielinska, Eva A., Panting, Emma, Hrabalkova, Lenka, Nicholson, Cara, Agnew, Emma J., Kemp, Matthew W., Morton, Nicholas M., Stock, Sarah J., Wyrwoll, Caitlin, Ganley, Ian G., Chapman, Karen E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals antenatal corticosteroids Birth Carbohydrates Cardiomyocytes Corticosteroids Dexamethasone Dexamethasone - pharmacology early‐life programming Embryos Energy metabolism Energy resources Fatty Acids Female Fetal Heart Fetuses Gene expression glucocorticoid Glucocorticoids Glucocorticoids - pharmacology Heart Metabolism Mice Mitochondria Myocytes, Cardiac Neonates Oxidation Palmitic acid Pregnancy Premature Birth preterm birth Receptors, Glucocorticoid - genetics Sheep Steroid hormones Steroids Structure-function relationships
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