Mitokyne: A Ratiometric Raman Probe for Mitochondrial pH

Mitochondrial pH (pHmito) is intimately related to mitochondrial function, and aberrant values for pHmito are linked to several disease states. We report the design, synthesis, and application of mitokyne 1the first small molecule pHmito sensor for stimulated Raman scattering (SRS) microscopy. This...

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Veröffentlicht in:	Analytical chemistry (Washington) 2021-09, Vol.93 (37), p.12786-12792
Hauptverfasser:	Wilson, Liam T, Tipping, William J, Wetherill, Corinna, Henley, Zoë, Faulds, Karen, Graham, Duncan, Mackay, Simon P, Tomkinson, Nicholas C. O
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP synthase Chemistry Electron transport Electron transport chain External stimuli Mitochondria pH effects Raman spectra Spatial discrimination Spatial resolution
Online-Zugang:	Volltext
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