Effects of the exercise training on skeletal muscle oxygen consumption in heart failure patients with reduced ejection fraction
Skeletal muscle dysfunction is a systemic consequence of heart failure (HF) that correlates with functional capacity. However, the impairment within the skeletal muscle is not well established. We investigated the effect of exercise training on peripheral muscular performance and oxygenation in HF p...
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| Veröffentlicht in: | International journal of cardiology 2021-11, Vol.343, p.73-79 |
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| creator | Guimarães, Guilherme Veiga Ribeiro, Fernando Castro, Rafael Ertner Roque, Jean Marcelo Machado, Alexander Douglas Teixeira Antunes-Correa, Ligia M. Ferreira, Silvia Ayub Bocchi, Edimar Alcides |
| description | Skeletal muscle dysfunction is a systemic consequence of heart failure (HF) that correlates with functional capacity. However, the impairment within the skeletal muscle is not well established. We investigated the effect of exercise training on peripheral muscular performance and oxygenation in HF patients.
HF patients with ejection fraction ≤40% were randomized 2:1 to exercise training or control for 12 weeks. Muscle tissue oxygen was measured noninvasively by near-infrared spectroscopy (NIRS) during rest and a symptom-limited cardiopulmonary exercise test (CPET) before and after intervention. Measurements included skeletal muscle oxygenated hemoglobin concentration, deoxygenated hemoglobin concentration, total hemoglobin concentration, VO2 peak, VE/VCO2 slope, and heart rate. Muscle sympathetic nerve activity by microneurography, and muscle blood flow by plethysmography were also assessed at rest pre and post 12 weeks. Twenty-four participants (47.5 ± 7.4 years, 58% men, 75% no ischemic) were allocated to exercise training (ET, n = 16) or control (CG, n = 8). At baseline, no differences between groups were found. Exercise improved VO2 peak, slope VE/VCO2, and heart rate. After the intervention, significant improvements at rest were seen in the ET group in muscle sympathetic nerve activity and muscle blood flow. Concomitantly, a significant decreased in Oxy-Hb (from 29.4 ± 20.4 to 15.7 ± 9.0 μmol, p = 0.01), Deoxi-Hb (from 16.3 ± 8.2 to 12.2 ± 6.0 μmol, p = 0.003) and HbT (from 45.7 ± 27.6 to 27.7 ± 13.4 μmol, p = 0.008) was detected at peak exercise after training. No changes were observed in the control group.
Exercise training improves skeletal muscle function and functional capacity in HF patients with reduced ejection fraction. This improvement was associated with increased oxygenation of the peripheral muscles, increased muscle blood flow, and decreased sympathetic nerve activity. |
| doi_str_mv | 10.1016/j.ijcard.2021.08.050 |
| format | Article |
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HF patients with ejection fraction ≤40% were randomized 2:1 to exercise training or control for 12 weeks. Muscle tissue oxygen was measured noninvasively by near-infrared spectroscopy (NIRS) during rest and a symptom-limited cardiopulmonary exercise test (CPET) before and after intervention. Measurements included skeletal muscle oxygenated hemoglobin concentration, deoxygenated hemoglobin concentration, total hemoglobin concentration, VO2 peak, VE/VCO2 slope, and heart rate. Muscle sympathetic nerve activity by microneurography, and muscle blood flow by plethysmography were also assessed at rest pre and post 12 weeks. Twenty-four participants (47.5 ± 7.4 years, 58% men, 75% no ischemic) were allocated to exercise training (ET, n = 16) or control (CG, n = 8). At baseline, no differences between groups were found. Exercise improved VO2 peak, slope VE/VCO2, and heart rate. After the intervention, significant improvements at rest were seen in the ET group in muscle sympathetic nerve activity and muscle blood flow. Concomitantly, a significant decreased in Oxy-Hb (from 29.4 ± 20.4 to 15.7 ± 9.0 μmol, p = 0.01), Deoxi-Hb (from 16.3 ± 8.2 to 12.2 ± 6.0 μmol, p = 0.003) and HbT (from 45.7 ± 27.6 to 27.7 ± 13.4 μmol, p = 0.008) was detected at peak exercise after training. No changes were observed in the control group.
Exercise training improves skeletal muscle function and functional capacity in HF patients with reduced ejection fraction. This improvement was associated with increased oxygenation of the peripheral muscles, increased muscle blood flow, and decreased sympathetic nerve activity.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2021.08.050</identifier><identifier>PMID: 34506822</identifier><language>eng</language><publisher>CLARE: Elsevier B.V</publisher><subject>Cardiac & Cardiovascular Systems ; Cardiovascular System & Cardiology ; Exercise training ; Forearm blood flow ; Heart failure ; Life Sciences & Biomedicine ; Muscle oxygenation ; Muscle sympathetic nerve activity ; Oxygen consumption ; Science & Technology</subject><ispartof>International journal of cardiology, 2021-11, Vol.343, p.73-79</ispartof><rights>2021 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>7</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000729963100021</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c339t-c558e33ebdd7c5e1cd981f5323e6640d481ccfea961093d8060c8f654c73fb533</citedby><cites>FETCH-LOGICAL-c339t-c558e33ebdd7c5e1cd981f5323e6640d481ccfea961093d8060c8f654c73fb533</cites><orcidid>0000-0001-9094-1493 ; 0000-0003-2304-3110</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijcard.2021.08.050$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,39263,46000</link.rule.ids></links><search><creatorcontrib>Guimarães, Guilherme Veiga</creatorcontrib><creatorcontrib>Ribeiro, Fernando</creatorcontrib><creatorcontrib>Castro, Rafael Ertner</creatorcontrib><creatorcontrib>Roque, Jean Marcelo</creatorcontrib><creatorcontrib>Machado, Alexander Douglas Teixeira</creatorcontrib><creatorcontrib>Antunes-Correa, Ligia M.</creatorcontrib><creatorcontrib>Ferreira, Silvia Ayub</creatorcontrib><creatorcontrib>Bocchi, Edimar Alcides</creatorcontrib><title>Effects of the exercise training on skeletal muscle oxygen consumption in heart failure patients with reduced ejection fraction</title><title>International journal of cardiology</title><addtitle>INT J CARDIOL</addtitle><description>Skeletal muscle dysfunction is a systemic consequence of heart failure (HF) that correlates with functional capacity. However, the impairment within the skeletal muscle is not well established. We investigated the effect of exercise training on peripheral muscular performance and oxygenation in HF patients.
HF patients with ejection fraction ≤40% were randomized 2:1 to exercise training or control for 12 weeks. Muscle tissue oxygen was measured noninvasively by near-infrared spectroscopy (NIRS) during rest and a symptom-limited cardiopulmonary exercise test (CPET) before and after intervention. Measurements included skeletal muscle oxygenated hemoglobin concentration, deoxygenated hemoglobin concentration, total hemoglobin concentration, VO2 peak, VE/VCO2 slope, and heart rate. Muscle sympathetic nerve activity by microneurography, and muscle blood flow by plethysmography were also assessed at rest pre and post 12 weeks. Twenty-four participants (47.5 ± 7.4 years, 58% men, 75% no ischemic) were allocated to exercise training (ET, n = 16) or control (CG, n = 8). At baseline, no differences between groups were found. Exercise improved VO2 peak, slope VE/VCO2, and heart rate. After the intervention, significant improvements at rest were seen in the ET group in muscle sympathetic nerve activity and muscle blood flow. Concomitantly, a significant decreased in Oxy-Hb (from 29.4 ± 20.4 to 15.7 ± 9.0 μmol, p = 0.01), Deoxi-Hb (from 16.3 ± 8.2 to 12.2 ± 6.0 μmol, p = 0.003) and HbT (from 45.7 ± 27.6 to 27.7 ± 13.4 μmol, p = 0.008) was detected at peak exercise after training. No changes were observed in the control group.
Exercise training improves skeletal muscle function and functional capacity in HF patients with reduced ejection fraction. This improvement was associated with increased oxygenation of the peripheral muscles, increased muscle blood flow, and decreased sympathetic nerve activity.</description><subject>Cardiac & Cardiovascular Systems</subject><subject>Cardiovascular System & Cardiology</subject><subject>Exercise training</subject><subject>Forearm blood flow</subject><subject>Heart failure</subject><subject>Life Sciences & Biomedicine</subject><subject>Muscle oxygenation</subject><subject>Muscle sympathetic nerve activity</subject><subject>Oxygen consumption</subject><subject>Science & Technology</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqNkE1vFCEYgImxsWv1H3jgaGJmhGEYmIuJ2dSPpImX9kxYeOkyzsIKjG1P_etlncaj8cR7eJ4XeBB6R0lLCR0-Tq2fjE627UhHWyJbwskLtKFS9A0VvH-JNhUTDe8EO0evc54IIf04ylfonPWcDLLrNujx0jkwJePocNkDhntIxmfAJWkffLjFMeD8E2YoesaHJZsZcLx_uIWATQx5ORyLr4gPeA86Fey0n5cE-KiLh1AX3_myxwnsYsBimOplJ94l_Wd4g86cnjO8fT4v0M2Xy-vtt-bqx9fv289XjWFsLI3hXAJjsLNWGA7U2FFSx1nHYBh6YntJjXGgx4GSkVlJBmKkG3hvBHM7ztgFer_uPab4a4Fc1MFnA_OsA8Qlq44LOlIxiL6i_YqaFHNO4NQx-YNOD4oSdUqvJrWmV6f0ikhV01ftw6rdwS66bOrvDfxVa3vRjePAaJ06Wmn5__TWF32KtY1LKFX9tKpQe_32kNSzbn2qdZWN_t8vfQJEPbBU</recordid><startdate>20211115</startdate><enddate>20211115</enddate><creator>Guimarães, Guilherme Veiga</creator><creator>Ribeiro, Fernando</creator><creator>Castro, Rafael Ertner</creator><creator>Roque, Jean Marcelo</creator><creator>Machado, Alexander Douglas Teixeira</creator><creator>Antunes-Correa, Ligia M.</creator><creator>Ferreira, Silvia Ayub</creator><creator>Bocchi, Edimar Alcides</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9094-1493</orcidid><orcidid>https://orcid.org/0000-0003-2304-3110</orcidid></search><sort><creationdate>20211115</creationdate><title>Effects of the exercise training on skeletal muscle oxygen consumption in heart failure patients with reduced ejection fraction</title><author>Guimarães, Guilherme Veiga ; Ribeiro, Fernando ; Castro, Rafael Ertner ; Roque, Jean Marcelo ; Machado, Alexander Douglas Teixeira ; Antunes-Correa, Ligia M. ; Ferreira, Silvia Ayub ; Bocchi, Edimar Alcides</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-c558e33ebdd7c5e1cd981f5323e6640d481ccfea961093d8060c8f654c73fb533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cardiac & Cardiovascular Systems</topic><topic>Cardiovascular System & Cardiology</topic><topic>Exercise training</topic><topic>Forearm blood flow</topic><topic>Heart failure</topic><topic>Life Sciences & Biomedicine</topic><topic>Muscle oxygenation</topic><topic>Muscle sympathetic nerve activity</topic><topic>Oxygen consumption</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guimarães, Guilherme Veiga</creatorcontrib><creatorcontrib>Ribeiro, Fernando</creatorcontrib><creatorcontrib>Castro, Rafael Ertner</creatorcontrib><creatorcontrib>Roque, Jean Marcelo</creatorcontrib><creatorcontrib>Machado, Alexander Douglas Teixeira</creatorcontrib><creatorcontrib>Antunes-Correa, Ligia M.</creatorcontrib><creatorcontrib>Ferreira, Silvia Ayub</creatorcontrib><creatorcontrib>Bocchi, Edimar Alcides</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guimarães, Guilherme Veiga</au><au>Ribeiro, Fernando</au><au>Castro, Rafael Ertner</au><au>Roque, Jean Marcelo</au><au>Machado, Alexander Douglas Teixeira</au><au>Antunes-Correa, Ligia M.</au><au>Ferreira, Silvia Ayub</au><au>Bocchi, Edimar Alcides</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of the exercise training on skeletal muscle oxygen consumption in heart failure patients with reduced ejection fraction</atitle><jtitle>International journal of cardiology</jtitle><stitle>INT J CARDIOL</stitle><date>2021-11-15</date><risdate>2021</risdate><volume>343</volume><spage>73</spage><epage>79</epage><pages>73-79</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><abstract>Skeletal muscle dysfunction is a systemic consequence of heart failure (HF) that correlates with functional capacity. However, the impairment within the skeletal muscle is not well established. We investigated the effect of exercise training on peripheral muscular performance and oxygenation in HF patients.
HF patients with ejection fraction ≤40% were randomized 2:1 to exercise training or control for 12 weeks. Muscle tissue oxygen was measured noninvasively by near-infrared spectroscopy (NIRS) during rest and a symptom-limited cardiopulmonary exercise test (CPET) before and after intervention. Measurements included skeletal muscle oxygenated hemoglobin concentration, deoxygenated hemoglobin concentration, total hemoglobin concentration, VO2 peak, VE/VCO2 slope, and heart rate. Muscle sympathetic nerve activity by microneurography, and muscle blood flow by plethysmography were also assessed at rest pre and post 12 weeks. Twenty-four participants (47.5 ± 7.4 years, 58% men, 75% no ischemic) were allocated to exercise training (ET, n = 16) or control (CG, n = 8). At baseline, no differences between groups were found. Exercise improved VO2 peak, slope VE/VCO2, and heart rate. After the intervention, significant improvements at rest were seen in the ET group in muscle sympathetic nerve activity and muscle blood flow. Concomitantly, a significant decreased in Oxy-Hb (from 29.4 ± 20.4 to 15.7 ± 9.0 μmol, p = 0.01), Deoxi-Hb (from 16.3 ± 8.2 to 12.2 ± 6.0 μmol, p = 0.003) and HbT (from 45.7 ± 27.6 to 27.7 ± 13.4 μmol, p = 0.008) was detected at peak exercise after training. No changes were observed in the control group.
Exercise training improves skeletal muscle function and functional capacity in HF patients with reduced ejection fraction. This improvement was associated with increased oxygenation of the peripheral muscles, increased muscle blood flow, and decreased sympathetic nerve activity.</abstract><cop>CLARE</cop><pub>Elsevier B.V</pub><pmid>34506822</pmid><doi>10.1016/j.ijcard.2021.08.050</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-9094-1493</orcidid><orcidid>https://orcid.org/0000-0003-2304-3110</orcidid></addata></record> |
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| subjects | Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Exercise training Forearm blood flow Heart failure Life Sciences & Biomedicine Muscle oxygenation Muscle sympathetic nerve activity Oxygen consumption Science & Technology |
| title | Effects of the exercise training on skeletal muscle oxygen consumption in heart failure patients with reduced ejection fraction |
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