Signaling Integration of Hydrogen Sulfide and Iron on Cellular Functions

Hydrogen sulfide (H S) is an endogenous signaling molecule, regulating numerous physiological functions from vasorelaxation to neuromodulation. Iron is a well-known bioactive metal ion, being the central component of hemoglobin for oxygen transportation and participating in biomolecule degradation,...

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Veröffentlicht in:Antioxidants & redox signaling 2022-02, Vol.36 (4-6), p.275-293
Hauptverfasser: Arif, Hassan Mustafa, Qian, Zhongming, Wang, Rui
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container_title Antioxidants & redox signaling
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creator Arif, Hassan Mustafa
Qian, Zhongming
Wang, Rui
description Hydrogen sulfide (H S) is an endogenous signaling molecule, regulating numerous physiological functions from vasorelaxation to neuromodulation. Iron is a well-known bioactive metal ion, being the central component of hemoglobin for oxygen transportation and participating in biomolecule degradation, redox balance, and enzymatic actions. The interplay between H S and iron metabolisms and functions impacts significantly on the fate and wellness of different types of cells. Iron level affects the production of H S nonenzymatic reactions. On the contrary, H S quenches excessive iron inside the cells and regulates the redox status of iron. Abnormal metabolisms of both iron and H S are associated with various conditions and diseases such as iron overload, anemia, oxidative stress, and cardiovascular and neurodegenerative diseases. The molecular mechanisms for the interactions between H S and iron are unsettled yet. Here we review signaling links of the production, metabolism, and their respective and integrative functions of H S and iron in normalcy and diseases. Physiological and pathophysiological importance of H S and iron as well as their therapeutic applications should be evaluated jointly, not separately. Future investigation should expand from iron-rich cells and tissues to the others, in which H S and iron interaction has not received due attention. 36, 275-293.
doi_str_mv 10.1089/ars.2021.0203
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subjects Anemia
Biomolecules
Hemoglobin
Hydrogen sulfide
Iron
Metabolism
Metal ions
Molecular modelling
Neurodegenerative diseases
Neuromodulation
Oxidative stress
Physiology
Signaling
Therapeutic applications
Vasodilation
title Signaling Integration of Hydrogen Sulfide and Iron on Cellular Functions
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