Signaling Integration of Hydrogen Sulfide and Iron on Cellular Functions
Hydrogen sulfide (H S) is an endogenous signaling molecule, regulating numerous physiological functions from vasorelaxation to neuromodulation. Iron is a well-known bioactive metal ion, being the central component of hemoglobin for oxygen transportation and participating in biomolecule degradation,...
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Veröffentlicht in: | Antioxidants & redox signaling 2022-02, Vol.36 (4-6), p.275-293 |
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creator | Arif, Hassan Mustafa Qian, Zhongming Wang, Rui |
description | Hydrogen sulfide (H
S) is an endogenous signaling molecule, regulating numerous physiological functions from vasorelaxation to neuromodulation. Iron is a well-known bioactive metal ion, being the central component of hemoglobin for oxygen transportation and participating in biomolecule degradation, redox balance, and enzymatic actions. The interplay between H
S and iron metabolisms and functions impacts significantly on the fate and wellness of different types of cells.
Iron level
affects the production of H
S
nonenzymatic reactions. On the contrary, H
S quenches excessive iron inside the cells and regulates the redox status of iron.
Abnormal metabolisms of both iron and H
S are associated with various conditions and diseases such as iron overload, anemia, oxidative stress, and cardiovascular and neurodegenerative diseases. The molecular mechanisms for the interactions between H
S and iron are unsettled yet. Here we review signaling links of the production, metabolism, and their respective and integrative functions of H
S and iron in normalcy and diseases.
Physiological and pathophysiological importance of H
S and iron as well as their therapeutic applications should be evaluated jointly, not separately. Future investigation should expand from iron-rich cells and tissues to the others, in which H
S and iron interaction has not received due attention.
36, 275-293. |
doi_str_mv | 10.1089/ars.2021.0203 |
format | Article |
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S) is an endogenous signaling molecule, regulating numerous physiological functions from vasorelaxation to neuromodulation. Iron is a well-known bioactive metal ion, being the central component of hemoglobin for oxygen transportation and participating in biomolecule degradation, redox balance, and enzymatic actions. The interplay between H
S and iron metabolisms and functions impacts significantly on the fate and wellness of different types of cells.
Iron level
affects the production of H
S
nonenzymatic reactions. On the contrary, H
S quenches excessive iron inside the cells and regulates the redox status of iron.
Abnormal metabolisms of both iron and H
S are associated with various conditions and diseases such as iron overload, anemia, oxidative stress, and cardiovascular and neurodegenerative diseases. The molecular mechanisms for the interactions between H
S and iron are unsettled yet. Here we review signaling links of the production, metabolism, and their respective and integrative functions of H
S and iron in normalcy and diseases.
Physiological and pathophysiological importance of H
S and iron as well as their therapeutic applications should be evaluated jointly, not separately. Future investigation should expand from iron-rich cells and tissues to the others, in which H
S and iron interaction has not received due attention.
36, 275-293.</description><identifier>ISSN: 1523-0864</identifier><identifier>EISSN: 1557-7716</identifier><identifier>DOI: 10.1089/ars.2021.0203</identifier><identifier>PMID: 34498949</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Anemia ; Biomolecules ; Hemoglobin ; Hydrogen sulfide ; Iron ; Metabolism ; Metal ions ; Molecular modelling ; Neurodegenerative diseases ; Neuromodulation ; Oxidative stress ; Physiology ; Signaling ; Therapeutic applications ; Vasodilation</subject><ispartof>Antioxidants & redox signaling, 2022-02, Vol.36 (4-6), p.275-293</ispartof><rights>Copyright Mary Ann Liebert, Inc. Feb 1, 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-77612c7d36dfb1bf0b1bf961898364cc9c3e8898fa0287b69c9c15b03587be233</citedby><cites>FETCH-LOGICAL-c321t-77612c7d36dfb1bf0b1bf961898364cc9c3e8898fa0287b69c9c15b03587be233</cites><orcidid>0000-0002-9033-4471 ; 0000-0003-3825-3620</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34498949$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arif, Hassan Mustafa</creatorcontrib><creatorcontrib>Qian, Zhongming</creatorcontrib><creatorcontrib>Wang, Rui</creatorcontrib><title>Signaling Integration of Hydrogen Sulfide and Iron on Cellular Functions</title><title>Antioxidants & redox signaling</title><addtitle>Antioxid Redox Signal</addtitle><description>Hydrogen sulfide (H
S) is an endogenous signaling molecule, regulating numerous physiological functions from vasorelaxation to neuromodulation. Iron is a well-known bioactive metal ion, being the central component of hemoglobin for oxygen transportation and participating in biomolecule degradation, redox balance, and enzymatic actions. The interplay between H
S and iron metabolisms and functions impacts significantly on the fate and wellness of different types of cells.
Iron level
affects the production of H
S
nonenzymatic reactions. On the contrary, H
S quenches excessive iron inside the cells and regulates the redox status of iron.
Abnormal metabolisms of both iron and H
S are associated with various conditions and diseases such as iron overload, anemia, oxidative stress, and cardiovascular and neurodegenerative diseases. The molecular mechanisms for the interactions between H
S and iron are unsettled yet. Here we review signaling links of the production, metabolism, and their respective and integrative functions of H
S and iron in normalcy and diseases.
Physiological and pathophysiological importance of H
S and iron as well as their therapeutic applications should be evaluated jointly, not separately. Future investigation should expand from iron-rich cells and tissues to the others, in which H
S and iron interaction has not received due attention.
36, 275-293.</description><subject>Anemia</subject><subject>Biomolecules</subject><subject>Hemoglobin</subject><subject>Hydrogen sulfide</subject><subject>Iron</subject><subject>Metabolism</subject><subject>Metal ions</subject><subject>Molecular modelling</subject><subject>Neurodegenerative diseases</subject><subject>Neuromodulation</subject><subject>Oxidative stress</subject><subject>Physiology</subject><subject>Signaling</subject><subject>Therapeutic applications</subject><subject>Vasodilation</subject><issn>1523-0864</issn><issn>1557-7716</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpdkD1PwzAQQC0EoqUwsiJLLCwp_kgce0RVSytVYijMluM4UarULnY89N_jqIWBxfb53p3uHgCPGM0x4uJV-TAniOA5IohegSkuijIrS8yuxzehGeIsn4C7EPYIJQ6jWzCheS64yMUUrHdda1Xf2RZu7GBar4bOWegauD7V3rXGwl3sm642UNkabvyYtHBh-j72ysNVtHqsCPfgplF9MA-Xewa-VsvPxTrbfrxvFm_bTFOChzQZw0SXNWV1U-GqQeMhGOaCU5ZrLTQ1PAWNQoSXFRPpBxcVokWKDKF0Bl7OfY_efUcTBnnogk7jKGtcDJIUJUa5oLRM6PM_dO-iT9smihFGCceMJyo7U9q7ELxp5NF3B-VPEiM5KpZJsRwVy1Fx4p8uXWN1MPUf_euU_gA1nHVp</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Arif, Hassan Mustafa</creator><creator>Qian, Zhongming</creator><creator>Wang, Rui</creator><general>Mary Ann Liebert, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9033-4471</orcidid><orcidid>https://orcid.org/0000-0003-3825-3620</orcidid></search><sort><creationdate>202202</creationdate><title>Signaling Integration of Hydrogen Sulfide and Iron on Cellular Functions</title><author>Arif, Hassan Mustafa ; Qian, Zhongming ; Wang, Rui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-77612c7d36dfb1bf0b1bf961898364cc9c3e8898fa0287b69c9c15b03587be233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anemia</topic><topic>Biomolecules</topic><topic>Hemoglobin</topic><topic>Hydrogen sulfide</topic><topic>Iron</topic><topic>Metabolism</topic><topic>Metal ions</topic><topic>Molecular modelling</topic><topic>Neurodegenerative diseases</topic><topic>Neuromodulation</topic><topic>Oxidative stress</topic><topic>Physiology</topic><topic>Signaling</topic><topic>Therapeutic applications</topic><topic>Vasodilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arif, Hassan Mustafa</creatorcontrib><creatorcontrib>Qian, Zhongming</creatorcontrib><creatorcontrib>Wang, Rui</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Antioxidants & redox signaling</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arif, Hassan Mustafa</au><au>Qian, Zhongming</au><au>Wang, Rui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Signaling Integration of Hydrogen Sulfide and Iron on Cellular Functions</atitle><jtitle>Antioxidants & redox signaling</jtitle><addtitle>Antioxid Redox Signal</addtitle><date>2022-02</date><risdate>2022</risdate><volume>36</volume><issue>4-6</issue><spage>275</spage><epage>293</epage><pages>275-293</pages><issn>1523-0864</issn><eissn>1557-7716</eissn><abstract>Hydrogen sulfide (H
S) is an endogenous signaling molecule, regulating numerous physiological functions from vasorelaxation to neuromodulation. Iron is a well-known bioactive metal ion, being the central component of hemoglobin for oxygen transportation and participating in biomolecule degradation, redox balance, and enzymatic actions. The interplay between H
S and iron metabolisms and functions impacts significantly on the fate and wellness of different types of cells.
Iron level
affects the production of H
S
nonenzymatic reactions. On the contrary, H
S quenches excessive iron inside the cells and regulates the redox status of iron.
Abnormal metabolisms of both iron and H
S are associated with various conditions and diseases such as iron overload, anemia, oxidative stress, and cardiovascular and neurodegenerative diseases. The molecular mechanisms for the interactions between H
S and iron are unsettled yet. Here we review signaling links of the production, metabolism, and their respective and integrative functions of H
S and iron in normalcy and diseases.
Physiological and pathophysiological importance of H
S and iron as well as their therapeutic applications should be evaluated jointly, not separately. Future investigation should expand from iron-rich cells and tissues to the others, in which H
S and iron interaction has not received due attention.
36, 275-293.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>34498949</pmid><doi>10.1089/ars.2021.0203</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0002-9033-4471</orcidid><orcidid>https://orcid.org/0000-0003-3825-3620</orcidid></addata></record> |
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source | Alma/SFX Local Collection |
subjects | Anemia Biomolecules Hemoglobin Hydrogen sulfide Iron Metabolism Metal ions Molecular modelling Neurodegenerative diseases Neuromodulation Oxidative stress Physiology Signaling Therapeutic applications Vasodilation |
title | Signaling Integration of Hydrogen Sulfide and Iron on Cellular Functions |
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