The effects of low‐intensity exercise on cardiac glycogenesis and glycolysis in male and ovariectomized female rats on a fructose‐rich diet
We previously reported that low‐intensity exercise prevented cardiac insulin resistance induced by a fructose‐rich diet (FRD). To examine whether low‐intensity exercise could prevent the disturbances of key molecules of cardiac glucose metabolism induced by FRD in male and ovariectomized (ovx) femal...
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| Veröffentlicht in: | Journal of food biochemistry 2021-10, Vol.45 (10), p.e13930-n/a |
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| creator | Stanisic, Jelena Koricanac, Goran Culafic, Tijana Romic, Snjezana Stojiljkovic, Mojca Kostic, Milan Ivkovic, Tamara Tepavcevic, Snezana |
| description | We previously reported that low‐intensity exercise prevented cardiac insulin resistance induced by a fructose‐rich diet (FRD). To examine whether low‐intensity exercise could prevent the disturbances of key molecules of cardiac glucose metabolism induced by FRD in male and ovariectomized (ovx) female rats, animals were exposed to 10% fructose solution (SF) or underwent both fructose diet and exercise (EF). Exercise prevented a decrease in cardiac GSK‐3β phosphorylation induced by FRD in males (p |
| doi_str_mv | 10.1111/jfbc.13930 |
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Practical applications
Low‐intensity exercise, equivalent to brisk walking, was able to prevent disturbances in cardiac glycolysis regulation in ovx female and the glycogen synthesis pathway in male rats. In terms of human health, although molecular mechanisms of beneficial effects of exercise on cardiac glucose metabolism vary between genders, low‐intensity running may be a useful non‐pharmacological approach in the prevention of cardiac metabolic disorders in both men and postmenopausal women.
Fructose‐rich diet affected cardiac glucose metabolism in male and ovx female rats differently. In fructose‐fed ovx female rats, low‐intensity exercise, equivalent to brisk walking, was able to prevent disturbances in phosphorylation of PFK‐2, which implicates increased glycolysis. Instead, in male rats, exercise exerted beneficial effect on regulation of phosphorylation of GSK‐3β, which implicates increased glycogen synthesis.</description><identifier>ISSN: 0145-8884</identifier><identifier>EISSN: 1745-4514</identifier><identifier>DOI: 10.1111/jfbc.13930</identifier><language>eng</language><subject>cardiac insulin resistance ; glucose transporters ; glycogen synthase kinase 3 ; hexokinase 2,6‐phosphofructo‐2‐kinase</subject><ispartof>Journal of food biochemistry, 2021-10, Vol.45 (10), p.e13930-n/a</ispartof><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3420-309521efa58573e1e8695598828601751dfd9ef9c454c4c6566a4e35c3e354f63</citedby><cites>FETCH-LOGICAL-c3420-309521efa58573e1e8695598828601751dfd9ef9c454c4c6566a4e35c3e354f63</cites><orcidid>0000-0003-4680-5835 ; 0000-0002-8161-3647 ; 0000-0001-8970-9291 ; 0000-0002-9041-7947 ; 0000-0002-3346-7438 ; 0000-0002-4365-9169 ; 0000-0002-9852-3330 ; 0000-0002-5758-070X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjfbc.13930$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjfbc.13930$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Stanisic, Jelena</creatorcontrib><creatorcontrib>Koricanac, Goran</creatorcontrib><creatorcontrib>Culafic, Tijana</creatorcontrib><creatorcontrib>Romic, Snjezana</creatorcontrib><creatorcontrib>Stojiljkovic, Mojca</creatorcontrib><creatorcontrib>Kostic, Milan</creatorcontrib><creatorcontrib>Ivkovic, Tamara</creatorcontrib><creatorcontrib>Tepavcevic, Snezana</creatorcontrib><title>The effects of low‐intensity exercise on cardiac glycogenesis and glycolysis in male and ovariectomized female rats on a fructose‐rich diet</title><title>Journal of food biochemistry</title><description>We previously reported that low‐intensity exercise prevented cardiac insulin resistance induced by a fructose‐rich diet (FRD). To examine whether low‐intensity exercise could prevent the disturbances of key molecules of cardiac glucose metabolism induced by FRD in male and ovariectomized (ovx) female rats, animals were exposed to 10% fructose solution (SF) or underwent both fructose diet and exercise (EF). Exercise prevented a decrease in cardiac GSK‐3β phosphorylation induced by FRD in males (p < .001 vs. SF). It also prevented a decrease in PFK‐2 phosphorylation in ovx females (p < .001 vs. SF) and increased the expression of PFK‐2 in males (p < .05 vs. control). Exercise did not prevent a decrease in plasma membrane GLUT1 and GLUT4 levels in ovx females on FRD. The only effect of exercise on glucose transporters that could be indicated as beneficial is an augmented GLUT4 protein expression in males (p < .05 vs. control). Obtained results suggest that low‐intensity exercise prevents harmful effects of FRD towards cardiac glycogenesis in males and glycolysis in ovx females.
Practical applications
Low‐intensity exercise, equivalent to brisk walking, was able to prevent disturbances in cardiac glycolysis regulation in ovx female and the glycogen synthesis pathway in male rats. In terms of human health, although molecular mechanisms of beneficial effects of exercise on cardiac glucose metabolism vary between genders, low‐intensity running may be a useful non‐pharmacological approach in the prevention of cardiac metabolic disorders in both men and postmenopausal women.
Fructose‐rich diet affected cardiac glucose metabolism in male and ovx female rats differently. In fructose‐fed ovx female rats, low‐intensity exercise, equivalent to brisk walking, was able to prevent disturbances in phosphorylation of PFK‐2, which implicates increased glycolysis. Instead, in male rats, exercise exerted beneficial effect on regulation of phosphorylation of GSK‐3β, which implicates increased glycogen synthesis.</description><subject>cardiac insulin resistance</subject><subject>glucose transporters</subject><subject>glycogen synthase kinase 3</subject><subject>hexokinase 2,6‐phosphofructo‐2‐kinase</subject><issn>0145-8884</issn><issn>1745-4514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9UEtOwzAUtBBIlMKGE3iJkFLs2M5nCRXlo0psyjoyznPryomLnVLCihvAGTkJScOat3jfeTPSIHROyYR2cbXWL2pCWc7IARrRlIuIC8oP0YjQrs-yjB-jkxDWhJA4T_gIfS1WgEFrUE3ATmPrdj-f36ZuoA6maTG8g1cmAHY1VtKXRiq8tK1yS6ghmIBlXQ4L2_ajqXElLezX7k160xG7ynxAiTXsL172SjWWWPttdwzQCXqjVrg00JyiIy1tgLO_OkbPs9vF9D6aP909TK_nkWI8JhEjuYgpaCkykTKgkCW5EHmWxVlCaCpoqcscdK644IqrRCSJ5MCEYl3iOmFjdDHwbrx73UJoisoEBdbKGtw2FLFICUsZ79jH6HKAKu9C8KCLjTeV9G1BSdG7XvSuF3vXOzAdwDtjof0HWTzObqbDzy8aS4hi</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Stanisic, Jelena</creator><creator>Koricanac, Goran</creator><creator>Culafic, Tijana</creator><creator>Romic, Snjezana</creator><creator>Stojiljkovic, Mojca</creator><creator>Kostic, Milan</creator><creator>Ivkovic, Tamara</creator><creator>Tepavcevic, Snezana</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4680-5835</orcidid><orcidid>https://orcid.org/0000-0002-8161-3647</orcidid><orcidid>https://orcid.org/0000-0001-8970-9291</orcidid><orcidid>https://orcid.org/0000-0002-9041-7947</orcidid><orcidid>https://orcid.org/0000-0002-3346-7438</orcidid><orcidid>https://orcid.org/0000-0002-4365-9169</orcidid><orcidid>https://orcid.org/0000-0002-9852-3330</orcidid><orcidid>https://orcid.org/0000-0002-5758-070X</orcidid></search><sort><creationdate>202110</creationdate><title>The effects of low‐intensity exercise on cardiac glycogenesis and glycolysis in male and ovariectomized female rats on a fructose‐rich diet</title><author>Stanisic, Jelena ; Koricanac, Goran ; Culafic, Tijana ; Romic, Snjezana ; Stojiljkovic, Mojca ; Kostic, Milan ; Ivkovic, Tamara ; Tepavcevic, Snezana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3420-309521efa58573e1e8695598828601751dfd9ef9c454c4c6566a4e35c3e354f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>cardiac insulin resistance</topic><topic>glucose transporters</topic><topic>glycogen synthase kinase 3</topic><topic>hexokinase 2,6‐phosphofructo‐2‐kinase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stanisic, Jelena</creatorcontrib><creatorcontrib>Koricanac, Goran</creatorcontrib><creatorcontrib>Culafic, Tijana</creatorcontrib><creatorcontrib>Romic, Snjezana</creatorcontrib><creatorcontrib>Stojiljkovic, Mojca</creatorcontrib><creatorcontrib>Kostic, Milan</creatorcontrib><creatorcontrib>Ivkovic, Tamara</creatorcontrib><creatorcontrib>Tepavcevic, Snezana</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of food biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stanisic, Jelena</au><au>Koricanac, Goran</au><au>Culafic, Tijana</au><au>Romic, Snjezana</au><au>Stojiljkovic, Mojca</au><au>Kostic, Milan</au><au>Ivkovic, Tamara</au><au>Tepavcevic, Snezana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of low‐intensity exercise on cardiac glycogenesis and glycolysis in male and ovariectomized female rats on a fructose‐rich diet</atitle><jtitle>Journal of food biochemistry</jtitle><date>2021-10</date><risdate>2021</risdate><volume>45</volume><issue>10</issue><spage>e13930</spage><epage>n/a</epage><pages>e13930-n/a</pages><issn>0145-8884</issn><eissn>1745-4514</eissn><abstract>We previously reported that low‐intensity exercise prevented cardiac insulin resistance induced by a fructose‐rich diet (FRD). To examine whether low‐intensity exercise could prevent the disturbances of key molecules of cardiac glucose metabolism induced by FRD in male and ovariectomized (ovx) female rats, animals were exposed to 10% fructose solution (SF) or underwent both fructose diet and exercise (EF). Exercise prevented a decrease in cardiac GSK‐3β phosphorylation induced by FRD in males (p < .001 vs. SF). It also prevented a decrease in PFK‐2 phosphorylation in ovx females (p < .001 vs. SF) and increased the expression of PFK‐2 in males (p < .05 vs. control). Exercise did not prevent a decrease in plasma membrane GLUT1 and GLUT4 levels in ovx females on FRD. The only effect of exercise on glucose transporters that could be indicated as beneficial is an augmented GLUT4 protein expression in males (p < .05 vs. control). Obtained results suggest that low‐intensity exercise prevents harmful effects of FRD towards cardiac glycogenesis in males and glycolysis in ovx females.
Practical applications
Low‐intensity exercise, equivalent to brisk walking, was able to prevent disturbances in cardiac glycolysis regulation in ovx female and the glycogen synthesis pathway in male rats. In terms of human health, although molecular mechanisms of beneficial effects of exercise on cardiac glucose metabolism vary between genders, low‐intensity running may be a useful non‐pharmacological approach in the prevention of cardiac metabolic disorders in both men and postmenopausal women.
Fructose‐rich diet affected cardiac glucose metabolism in male and ovx female rats differently. In fructose‐fed ovx female rats, low‐intensity exercise, equivalent to brisk walking, was able to prevent disturbances in phosphorylation of PFK‐2, which implicates increased glycolysis. Instead, in male rats, exercise exerted beneficial effect on regulation of phosphorylation of GSK‐3β, which implicates increased glycogen synthesis.</abstract><doi>10.1111/jfbc.13930</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-4680-5835</orcidid><orcidid>https://orcid.org/0000-0002-8161-3647</orcidid><orcidid>https://orcid.org/0000-0001-8970-9291</orcidid><orcidid>https://orcid.org/0000-0002-9041-7947</orcidid><orcidid>https://orcid.org/0000-0002-3346-7438</orcidid><orcidid>https://orcid.org/0000-0002-4365-9169</orcidid><orcidid>https://orcid.org/0000-0002-9852-3330</orcidid><orcidid>https://orcid.org/0000-0002-5758-070X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | cardiac insulin resistance glucose transporters glycogen synthase kinase 3 hexokinase 2,6‐phosphofructo‐2‐kinase |
| title | The effects of low‐intensity exercise on cardiac glycogenesis and glycolysis in male and ovariectomized female rats on a fructose‐rich diet |
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