Distinct genetic landscape and a low response to doxorubicin in a luminal-A breast cancer cell line of Pakistani origin

Background Breast cancers exhibit genetic heterogeneity which causes differential responses to various chemotherapy agents. Given the unique demographic and genomic background in South Asia, genetic architecture in breast cancers is not fully explored. Methods and results In this study, we determine...

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Veröffentlicht in:	Molecular biology reports 2021-10, Vol.48 (10), p.6821-6829
Hauptverfasser:	Shakeel, Muhammad, Khan, Salman Ahmed, Mughal, Anum Jabeen, Irfan, Muhammad, Hoessli, Daniel C., Choudhary, M. Iqbal, Aurongzeb, Muhammad, Khan, Ishtiaq Ahmad
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animal Anatomy Animal Biochemistry Biomedical and Life Sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Cell cycle Cell Line, Tumor Chemotherapy DNA damage DNA repair Double-strand break repair Doxorubicin Doxorubicin - pharmacology Doxorubicin - therapeutic use ErbB protein Female Histology Homologous recombination Humans Insertion Life Sciences Morphology Mutation Mutation - genetics Original Article Pakistan Precision medicine Rap1 protein Signal transduction Transcription
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