Therapeutic importance of Cucurbitaceae: A medicinally important family
Medicinal plants of Cucurbitaceae family consist of several edible fruits and vegetables consumed worldwide since ancient times. The plants of this family have played an essential role in the ethnopharmacological as well as traditional medicinal system globally and their evidence is well established...
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| Veröffentlicht in: | Journal of ethnopharmacology 2022-01, Vol.282, p.114599-114599, Article 114599 |
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| creator | Mukherjee, Pulok K. Singha, Seha Kar, Amit Chanda, Joydeb Banerjee, Subhadip Dasgupta, Barun Haldar, Pallab K. Sharma, Nanaocha |
| description | Medicinal plants of Cucurbitaceae family consist of several edible fruits and vegetables consumed worldwide since ancient times. The plants of this family have played an essential role in the ethnopharmacological as well as traditional medicinal system globally and their evidence is well established in several traditional literatures. Various plant parts have been used to treat several human ailments viz. Pandu (anemia), Pliharoga (splenomegaly), Sopha (inflammation), Gulma (tumor growth), Adhmana (indigestion. acidity), Garavisa (poisoning) etc.
This review article aims to systematically document and bridge scientific evidences with the ethnopharmacological, ethnoveterinary and folklore claims along with the therapeutic efficacy with mechanism of action found in different literature, books, and scientific articles belonging to the Cucurbitaceae family.
To construct the manuscript a comprehensive literature review was done based on the information collected from Ayurvedic Pharmacopoeia of India; books, research articles and databases such as ScienceDirect, Wiley Online Library, SciFinder, Scopus, Springer, Google Scholar, Web of Science, ACS Publications and PubMed.
The plants of Cucurbitaceae family are rich in phytochemicals like terpenoids, glycosides, alkaloids, saponins, tannins, steroids, etc., responsible for the therapeutic effect. Various parts of these plants such as leaves, stems, flowers, fruits, seeds, roots etc. exhibit a plethora of pharmacological activity viz. hypolipidemic, antihyperglycemic, anticancer, antimicrobial, analgesic, anti-inflammatory, anti-stress and immunomodulatory activities. Also, in-vitro and in-vivo reports suggest strong inhibitory potential against α-glucosidase, α-amylase, lipase, carbonic anhydrase enzyme along with antioxidant, anti-inflammatory, antidiabetic, anti-tumor, antifungal, etc. Furthermore many reports suggest these plants are beneficial for nutritional, economical and ethnoveterinary uses.
The current review enlightens the therapeutic potential of the gourd family, comprising of the geographical origins, morphology, phytochemistry, ethnopharmacology, ethnoveterinary, nutritional importance, therapeutic benefits, safety, efficacy and related aspects. The phytochemical and pharmacological potential indicated will popularize this family as a potential source of novel therapeutic agents and functional foods. This study will help to validate the therapeutic claims of several ethnomedicinal uses of this plan |
| doi_str_mv | 10.1016/j.jep.2021.114599 |
| format | Article |
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This review article aims to systematically document and bridge scientific evidences with the ethnopharmacological, ethnoveterinary and folklore claims along with the therapeutic efficacy with mechanism of action found in different literature, books, and scientific articles belonging to the Cucurbitaceae family.
To construct the manuscript a comprehensive literature review was done based on the information collected from Ayurvedic Pharmacopoeia of India; books, research articles and databases such as ScienceDirect, Wiley Online Library, SciFinder, Scopus, Springer, Google Scholar, Web of Science, ACS Publications and PubMed.
The plants of Cucurbitaceae family are rich in phytochemicals like terpenoids, glycosides, alkaloids, saponins, tannins, steroids, etc., responsible for the therapeutic effect. Various parts of these plants such as leaves, stems, flowers, fruits, seeds, roots etc. exhibit a plethora of pharmacological activity viz. hypolipidemic, antihyperglycemic, anticancer, antimicrobial, analgesic, anti-inflammatory, anti-stress and immunomodulatory activities. Also, in-vitro and in-vivo reports suggest strong inhibitory potential against α-glucosidase, α-amylase, lipase, carbonic anhydrase enzyme along with antioxidant, anti-inflammatory, antidiabetic, anti-tumor, antifungal, etc. Furthermore many reports suggest these plants are beneficial for nutritional, economical and ethnoveterinary uses.
The current review enlightens the therapeutic potential of the gourd family, comprising of the geographical origins, morphology, phytochemistry, ethnopharmacology, ethnoveterinary, nutritional importance, therapeutic benefits, safety, efficacy and related aspects. The phytochemical and pharmacological potential indicated will popularize this family as a potential source of novel therapeutic agents and functional foods. This study will help to validate the therapeutic claims of several ethnomedicinal uses of this plant family. Furthermore the Cucurbitaceae family needs to be evaluated based on the combine approaches of chemoprofiling and bioexploration to develop the concept of food as medicine for the development of new generation therapeutics leading to the human wellness.
[Display omitted]
•Cucurbitaceae is the largest plant family of vegetable and fruit which consists of 125 genera and 960 species (approx).•The plants belongs to Cucurbitaceae family are commonly annual or perennial.•Cucurbitaceae family plant is a large source of primary as well as secondary metabolites.•Plants of Cucurbitaceaea family exhibits a large range of pharmacological and ethnoveterinary uses.•Different parts of Cucurbitaceae family plants having nutritional as well as economic importance.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2021.114599</identifier><identifier>PMID: 34487849</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Cucurbitaceae ; Ethnopharmacology - methods ; Ethnopharmacology - trends ; Food plants ; Functional Food ; Humans ; Medicine, Traditional - methods ; Medicine, Traditional - trends ; Nutritional ; Pharmacology ; Phytochemical ; Phytochemicals - pharmacology ; Plants, Medicinal ; Therapeutic</subject><ispartof>Journal of ethnopharmacology, 2022-01, Vol.282, p.114599-114599, Article 114599</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-ba2efea308b3e6c8a8cd4664867e2479652d9b4de1d78288581051760a0cc7243</citedby><cites>FETCH-LOGICAL-c353t-ba2efea308b3e6c8a8cd4664867e2479652d9b4de1d78288581051760a0cc7243</cites><orcidid>0000-0001-8251-415X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2021.114599$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34487849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mukherjee, Pulok K.</creatorcontrib><creatorcontrib>Singha, Seha</creatorcontrib><creatorcontrib>Kar, Amit</creatorcontrib><creatorcontrib>Chanda, Joydeb</creatorcontrib><creatorcontrib>Banerjee, Subhadip</creatorcontrib><creatorcontrib>Dasgupta, Barun</creatorcontrib><creatorcontrib>Haldar, Pallab K.</creatorcontrib><creatorcontrib>Sharma, Nanaocha</creatorcontrib><title>Therapeutic importance of Cucurbitaceae: A medicinally important family</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Medicinal plants of Cucurbitaceae family consist of several edible fruits and vegetables consumed worldwide since ancient times. The plants of this family have played an essential role in the ethnopharmacological as well as traditional medicinal system globally and their evidence is well established in several traditional literatures. Various plant parts have been used to treat several human ailments viz. Pandu (anemia), Pliharoga (splenomegaly), Sopha (inflammation), Gulma (tumor growth), Adhmana (indigestion. acidity), Garavisa (poisoning) etc.
This review article aims to systematically document and bridge scientific evidences with the ethnopharmacological, ethnoveterinary and folklore claims along with the therapeutic efficacy with mechanism of action found in different literature, books, and scientific articles belonging to the Cucurbitaceae family.
To construct the manuscript a comprehensive literature review was done based on the information collected from Ayurvedic Pharmacopoeia of India; books, research articles and databases such as ScienceDirect, Wiley Online Library, SciFinder, Scopus, Springer, Google Scholar, Web of Science, ACS Publications and PubMed.
The plants of Cucurbitaceae family are rich in phytochemicals like terpenoids, glycosides, alkaloids, saponins, tannins, steroids, etc., responsible for the therapeutic effect. Various parts of these plants such as leaves, stems, flowers, fruits, seeds, roots etc. exhibit a plethora of pharmacological activity viz. hypolipidemic, antihyperglycemic, anticancer, antimicrobial, analgesic, anti-inflammatory, anti-stress and immunomodulatory activities. Also, in-vitro and in-vivo reports suggest strong inhibitory potential against α-glucosidase, α-amylase, lipase, carbonic anhydrase enzyme along with antioxidant, anti-inflammatory, antidiabetic, anti-tumor, antifungal, etc. Furthermore many reports suggest these plants are beneficial for nutritional, economical and ethnoveterinary uses.
The current review enlightens the therapeutic potential of the gourd family, comprising of the geographical origins, morphology, phytochemistry, ethnopharmacology, ethnoveterinary, nutritional importance, therapeutic benefits, safety, efficacy and related aspects. The phytochemical and pharmacological potential indicated will popularize this family as a potential source of novel therapeutic agents and functional foods. This study will help to validate the therapeutic claims of several ethnomedicinal uses of this plant family. Furthermore the Cucurbitaceae family needs to be evaluated based on the combine approaches of chemoprofiling and bioexploration to develop the concept of food as medicine for the development of new generation therapeutics leading to the human wellness.
[Display omitted]
•Cucurbitaceae is the largest plant family of vegetable and fruit which consists of 125 genera and 960 species (approx).•The plants belongs to Cucurbitaceae family are commonly annual or perennial.•Cucurbitaceae family plant is a large source of primary as well as secondary metabolites.•Plants of Cucurbitaceaea family exhibits a large range of pharmacological and ethnoveterinary uses.•Different parts of Cucurbitaceae family plants having nutritional as well as economic importance.</description><subject>Cucurbitaceae</subject><subject>Ethnopharmacology - methods</subject><subject>Ethnopharmacology - trends</subject><subject>Food plants</subject><subject>Functional Food</subject><subject>Humans</subject><subject>Medicine, Traditional - methods</subject><subject>Medicine, Traditional - trends</subject><subject>Nutritional</subject><subject>Pharmacology</subject><subject>Phytochemical</subject><subject>Phytochemicals - pharmacology</subject><subject>Plants, Medicinal</subject><subject>Therapeutic</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLFOwzAURS0EoqXwASwoI0uCn-3EDkyogoJUiaXMluO8CEdJE-wEqX9PqpaOTHc590r3EHILNAEK2UOd1NgnjDJIAESa52dkDkqyWKaSn5M55VLFSgqYkasQakqpBEEvyYwLoaQS-ZysNl_oTY_j4Gzk2r7zg9lajLoqWo529IUbjEWDj9Fz1GLprNuaptmd0CGqTOua3TW5qEwT8OaYC_L5-rJZvsXrj9X78nkdW57yIS4MwwoNp6rgmFlllC1FlgmVSWRC5lnKyrwQJUIpFVMqVUBTkBk11FrJBF-Q-8Nu77vvEcOgWxcsNo3ZYjcGzVJJAVjG2YTCAbW-C8FjpXvvWuN3Gqje-9O1nvzpvT998Dd17o7zYzHdPTX-hE3A0wHA6eSPQ6-DdTgZK51HO-iyc__M_wKWQX_E</recordid><startdate>20220110</startdate><enddate>20220110</enddate><creator>Mukherjee, Pulok K.</creator><creator>Singha, Seha</creator><creator>Kar, Amit</creator><creator>Chanda, Joydeb</creator><creator>Banerjee, Subhadip</creator><creator>Dasgupta, Barun</creator><creator>Haldar, Pallab K.</creator><creator>Sharma, Nanaocha</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8251-415X</orcidid></search><sort><creationdate>20220110</creationdate><title>Therapeutic importance of Cucurbitaceae: A medicinally important family</title><author>Mukherjee, Pulok K. ; Singha, Seha ; Kar, Amit ; Chanda, Joydeb ; Banerjee, Subhadip ; Dasgupta, Barun ; Haldar, Pallab K. ; Sharma, Nanaocha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-ba2efea308b3e6c8a8cd4664867e2479652d9b4de1d78288581051760a0cc7243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cucurbitaceae</topic><topic>Ethnopharmacology - methods</topic><topic>Ethnopharmacology - trends</topic><topic>Food plants</topic><topic>Functional Food</topic><topic>Humans</topic><topic>Medicine, Traditional - methods</topic><topic>Medicine, Traditional - trends</topic><topic>Nutritional</topic><topic>Pharmacology</topic><topic>Phytochemical</topic><topic>Phytochemicals - pharmacology</topic><topic>Plants, Medicinal</topic><topic>Therapeutic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mukherjee, Pulok K.</creatorcontrib><creatorcontrib>Singha, Seha</creatorcontrib><creatorcontrib>Kar, Amit</creatorcontrib><creatorcontrib>Chanda, Joydeb</creatorcontrib><creatorcontrib>Banerjee, Subhadip</creatorcontrib><creatorcontrib>Dasgupta, Barun</creatorcontrib><creatorcontrib>Haldar, Pallab K.</creatorcontrib><creatorcontrib>Sharma, Nanaocha</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mukherjee, Pulok K.</au><au>Singha, Seha</au><au>Kar, Amit</au><au>Chanda, Joydeb</au><au>Banerjee, Subhadip</au><au>Dasgupta, Barun</au><au>Haldar, Pallab K.</au><au>Sharma, Nanaocha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic importance of Cucurbitaceae: A medicinally important family</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2022-01-10</date><risdate>2022</risdate><volume>282</volume><spage>114599</spage><epage>114599</epage><pages>114599-114599</pages><artnum>114599</artnum><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>Medicinal plants of Cucurbitaceae family consist of several edible fruits and vegetables consumed worldwide since ancient times. The plants of this family have played an essential role in the ethnopharmacological as well as traditional medicinal system globally and their evidence is well established in several traditional literatures. Various plant parts have been used to treat several human ailments viz. Pandu (anemia), Pliharoga (splenomegaly), Sopha (inflammation), Gulma (tumor growth), Adhmana (indigestion. acidity), Garavisa (poisoning) etc.
This review article aims to systematically document and bridge scientific evidences with the ethnopharmacological, ethnoveterinary and folklore claims along with the therapeutic efficacy with mechanism of action found in different literature, books, and scientific articles belonging to the Cucurbitaceae family.
To construct the manuscript a comprehensive literature review was done based on the information collected from Ayurvedic Pharmacopoeia of India; books, research articles and databases such as ScienceDirect, Wiley Online Library, SciFinder, Scopus, Springer, Google Scholar, Web of Science, ACS Publications and PubMed.
The plants of Cucurbitaceae family are rich in phytochemicals like terpenoids, glycosides, alkaloids, saponins, tannins, steroids, etc., responsible for the therapeutic effect. Various parts of these plants such as leaves, stems, flowers, fruits, seeds, roots etc. exhibit a plethora of pharmacological activity viz. hypolipidemic, antihyperglycemic, anticancer, antimicrobial, analgesic, anti-inflammatory, anti-stress and immunomodulatory activities. Also, in-vitro and in-vivo reports suggest strong inhibitory potential against α-glucosidase, α-amylase, lipase, carbonic anhydrase enzyme along with antioxidant, anti-inflammatory, antidiabetic, anti-tumor, antifungal, etc. Furthermore many reports suggest these plants are beneficial for nutritional, economical and ethnoveterinary uses.
The current review enlightens the therapeutic potential of the gourd family, comprising of the geographical origins, morphology, phytochemistry, ethnopharmacology, ethnoveterinary, nutritional importance, therapeutic benefits, safety, efficacy and related aspects. The phytochemical and pharmacological potential indicated will popularize this family as a potential source of novel therapeutic agents and functional foods. This study will help to validate the therapeutic claims of several ethnomedicinal uses of this plant family. Furthermore the Cucurbitaceae family needs to be evaluated based on the combine approaches of chemoprofiling and bioexploration to develop the concept of food as medicine for the development of new generation therapeutics leading to the human wellness.
[Display omitted]
•Cucurbitaceae is the largest plant family of vegetable and fruit which consists of 125 genera and 960 species (approx).•The plants belongs to Cucurbitaceae family are commonly annual or perennial.•Cucurbitaceae family plant is a large source of primary as well as secondary metabolites.•Plants of Cucurbitaceaea family exhibits a large range of pharmacological and ethnoveterinary uses.•Different parts of Cucurbitaceae family plants having nutritional as well as economic importance.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>34487849</pmid><doi>10.1016/j.jep.2021.114599</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-8251-415X</orcidid></addata></record> |
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| ispartof | Journal of ethnopharmacology, 2022-01, Vol.282, p.114599-114599, Article 114599 |
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| subjects | Cucurbitaceae Ethnopharmacology - methods Ethnopharmacology - trends Food plants Functional Food Humans Medicine, Traditional - methods Medicine, Traditional - trends Nutritional Pharmacology Phytochemical Phytochemicals - pharmacology Plants, Medicinal Therapeutic |
| title | Therapeutic importance of Cucurbitaceae: A medicinally important family |
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