Vitamin D/Vitamin D Receptor Signaling Attenuates Skeletal Muscle Atrophy by Suppressing Renin‐Angiotensin System

ABSTRACT The nutritional level of vitamin D may affect musculoskeletal health. We have reported that vitamin D is a pivotal protector against tissue injuries by suppressing local renin‐angiotensin system (RAS). This study aimed to explore the role of the vitamin D receptor (VDR) in the protection ag...

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Veröffentlicht in:	Journal of bone and mineral research 2022-01, Vol.37 (1), p.121-136
Hauptverfasser:	Li, Wen‐Xiong, Qin, Xian‐Hui, Poon, Christina Chui‐Wa, Wong, Man‐Sau, Feng, Rui, Wang, Jing, Lin, Fu‐Hui, Sun, Yue‐Li, Liu, Shu‐Fen, Wang, Yong‐Jun, Zhang, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 25-Hydroxyvitamin D AKT protein Angiotensin ANGIOTENSIN II Animals Atrophy Calcitriol China Cross-Sectional Studies Dexamethasone Forkhead protein FOXO1 protein Kinases Mice MUSCLE ATROPHY Muscle Fibers, Skeletal - metabolism Muscle Fibers, Skeletal - pathology Muscle strength Muscle, Skeletal - pathology Muscular Atrophy - drug therapy Muscular Atrophy - metabolism Musculoskeletal system Myoblasts MyoD protein MYOGENESIS Myosin Myotubes Phenotypes Phosphatidylinositol 3-Kinases - metabolism Receptors, Calcitriol - metabolism Renin Renin-Angiotensin System Satellite cells Skeletal muscle Ubiquitin VITAMIN D Vitamin D - adverse effects VITAMIN D RECEPTOR Vitamin D receptors
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