Copper( ii ) mediated ortho C–H alkoxylation of aromatic amines using organic peroxides: efficient synthesis of hindered ethers

Synthesis of hindered alkyl aryl ether derivatives (R–O–Ar) remains a huge challenge and highly desirable in organic and medicinal chemistry because extensive substitution on the ether bond prevents the undesired metabolic process and thus avoids rapid degradation in vivo . Herein, we report an unpr...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2021-09, Vol.57 (71), p.8949-8952
Hauptverfasser:	Sarkar, Souvik, Sahoo, Tapan, Sen, Chiranjit, Ghosh, Subhash Chandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Aromatic compounds Copper Copper compounds Crystallography Ethers Organic peroxides Peroxides Retirement Synthesis
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description	Synthesis of hindered alkyl aryl ether derivatives (R–O–Ar) remains a huge challenge and highly desirable in organic and medicinal chemistry because extensive substitution on the ether bond prevents the undesired metabolic process and thus avoids rapid degradation in vivo . Herein, we report an unprecedented hindered alkoxylation of picolinamide attached aromatic amines using economic copper salt and organic peroxide to get highly desirable α-tertiary alkyl aryl ethers.
doi_str_mv	10.1039/d1cc01803e
format	Article
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source	Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects	Amines Aromatic compounds Copper Copper compounds Crystallography Ethers Organic peroxides Peroxides Retirement Synthesis
title	Copper( ii ) mediated ortho C–H alkoxylation of aromatic amines using organic peroxides: efficient synthesis of hindered ethers
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