Tenofovir-diphosphate in peripheral blood mononuclear cells during low, medium and high adherence to emtricitabine/ tenofovir alafenamide vs. emtricitabine/ tenofovir disoproxil fumarate

Tenofovir alafenamide (TAF) preferentially loads peripheral blood mononuclear cells (PBMCs), resulting in higher PBMC tenofovir-diphosphate (TFV-DP) vs. tenofovir disoproxil fumarate (TDF). No studies have yet compared TFV-DP in PBMC from lower than daily dosing between prodrugs, which has potential...

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Veröffentlicht in:	AIDS (London) 2021-12, Vol.35 (15), p.2481-2487
Hauptverfasser:	Yager, Jenna L, Brooks, Kristina M, Castillo-Mancilla, Jose R, Nemkov, Cricket, Morrow, Mary, Peterson, Skyler, Ibrahim, Mustafa, Bushman, Lane, Kiser, Jennifer J, MaWhinney, Samantha, Anderson, Peter L
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Anti-HIV Agents - therapeutic use Diphosphates - therapeutic use Emtricitabine - therapeutic use HIV Infections - drug therapy Humans Leukocytes, Mononuclear Tenofovir - analogs & derivatives Tenofovir - therapeutic use
Online-Zugang:	Volltext
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