The effects of capsinoids and fermented red pepper paste supplementation on Glycaemic Control: A systematic review and meta‐analysis of randomised controlled trials
Objective The present systematic review and meta‐analysis were conducted to investigate the effects of capsinoids supplementation on glycaemic control. Methods Relevant studies, published up to May 2020, were searched through PubMed/Medline, Scopus, ISI Web of Science, Embase and Google Scholar. All...
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| Veröffentlicht in: | International journal of clinical practice (Esher) 2021-12, Vol.75 (12), p.e14803-n/a |
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| container_title | International journal of clinical practice (Esher) |
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| creator | Amini, Mohammad Reza Talebyan, Alireza Payandeh, Nastaran Sheikhhossein, Fatemeh Mohtashaminia, Fatemeh Gholami, Fatemeh |
| description | Objective
The present systematic review and meta‐analysis were conducted to investigate the effects of capsinoids supplementation on glycaemic control.
Methods
Relevant studies, published up to May 2020, were searched through PubMed/Medline, Scopus, ISI Web of Science, Embase and Google Scholar. All randomised clinical trials investigating the effect of capsinoids supplementation on glycaemic control were included.
Results
Of 326 citations, eight trials with nine effect sizes that enrolled 530 subjects were included. Capsinoids and red pepper resulted in no significant reduction in glucose (Weighted mean differences (WMD): −0.27 mg/dL; 95% CI: −1.9 to 1.37, P = .75), insulin (WMD: −0.09 µU/mL; 95% CI: −1.76 to 1.57, P = .913), homeostatic model assessment for insulin resistance (HOMA‐IR) (WMD: 0.52; 95% CI: −0.29 to 1.32, P = .208) and haemoglobin A1C (HbA1C) (WMD: 0.01%; 95% CI: −0.04 to 0.05, P = .712). Greater effects on glucose were detected in trials performed on both gender, using red pepper, lasted ≥12 weeks, and participants aged >40 years old and recruited greater sample size >50. Insulin and HOMA‐IR were reduced by using red pepper.
Conclusion
Overall, these data suggest that capsinoids and red pepper supplementation did not have beneficial effects on glucose, insulin, HbA1C and HOMA‐IR but significantly reduce glucose in people older than 40 years. |
| doi_str_mv | 10.1111/ijcp.14803 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2569616897</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2614981450</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3933-d4a7312090a162676da1b42a3d6b90c5c13c79d92bf3227a87027b240d14c67a3</originalsourceid><addsrcrecordid>eNp9kU9u1TAQxi1ERcuDDQdAltggpBT_i52wq55KW1QJFmUdOfZE-CmJjZ20yo4j9BQcjJPU76WwYFHL1ozs33xj-0PoDSWnNI-PbmfCKRUV4c_QCVWCFZQJ-jznXFZFSTg9Ri9T2hHCyrIiL9AxF6JSvBIn6PfND8DQdWCmhH2HjQ7Jjd7ZhPVocQdxgHECi2NeAUKAiINOE-A0h9DD_lRPzo84z4t-MRoGZ_DWj1P0_Sd8htOS6SEzJmvcOrg7CA8w6T-_7vWo-yW5Q-uY9_3gUm5k1vI-p1N0uk-v0FGXA7x-jBv0_fP5zfayuP56cbU9uy4MrzkvrNCKU0ZqoqlkUkmraSuY5la2NTGlodyo2tas7ThjSleKMNUyQSwVRirNN-j9qhui_zlDmpp8IQN9r0fwc2pYKWtJZVWrjL77D935Oeb3ZEpSUVdU5K_foA8rZaJPKULXhOgGHZeGkmbvXrN3rzm4l-G3j5JzO4D9h_61KwN0Be5cD8sTUs3Vl-23VfQBuzun_A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2614981450</pqid></control><display><type>article</type><title>The effects of capsinoids and fermented red pepper paste supplementation on Glycaemic Control: A systematic review and meta‐analysis of randomised controlled trials</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Amini, Mohammad Reza ; Talebyan, Alireza ; Payandeh, Nastaran ; Sheikhhossein, Fatemeh ; Mohtashaminia, Fatemeh ; Gholami, Fatemeh</creator><creatorcontrib>Amini, Mohammad Reza ; Talebyan, Alireza ; Payandeh, Nastaran ; Sheikhhossein, Fatemeh ; Mohtashaminia, Fatemeh ; Gholami, Fatemeh</creatorcontrib><description>Objective
The present systematic review and meta‐analysis were conducted to investigate the effects of capsinoids supplementation on glycaemic control.
Methods
Relevant studies, published up to May 2020, were searched through PubMed/Medline, Scopus, ISI Web of Science, Embase and Google Scholar. All randomised clinical trials investigating the effect of capsinoids supplementation on glycaemic control were included.
Results
Of 326 citations, eight trials with nine effect sizes that enrolled 530 subjects were included. Capsinoids and red pepper resulted in no significant reduction in glucose (Weighted mean differences (WMD): −0.27 mg/dL; 95% CI: −1.9 to 1.37, P = .75), insulin (WMD: −0.09 µU/mL; 95% CI: −1.76 to 1.57, P = .913), homeostatic model assessment for insulin resistance (HOMA‐IR) (WMD: 0.52; 95% CI: −0.29 to 1.32, P = .208) and haemoglobin A1C (HbA1C) (WMD: 0.01%; 95% CI: −0.04 to 0.05, P = .712). Greater effects on glucose were detected in trials performed on both gender, using red pepper, lasted ≥12 weeks, and participants aged >40 years old and recruited greater sample size >50. Insulin and HOMA‐IR were reduced by using red pepper.
Conclusion
Overall, these data suggest that capsinoids and red pepper supplementation did not have beneficial effects on glucose, insulin, HbA1C and HOMA‐IR but significantly reduce glucose in people older than 40 years.</description><identifier>ISSN: 1368-5031</identifier><identifier>EISSN: 1742-1241</identifier><identifier>DOI: 10.1111/ijcp.14803</identifier><identifier>PMID: 34487384</identifier><language>eng</language><publisher>England: Hindawi Limited</publisher><subject>Adult ; Blood Glucose ; Capsicum ; Clinical trials ; Dietary Supplements ; Fermented food ; Glucose ; Glycated Hemoglobin A ; Hemoglobin ; Humans ; Insulin ; Insulin Resistance ; Meta-analysis ; Randomized Controlled Trials as Topic ; Supplements ; Systematic review</subject><ispartof>International journal of clinical practice (Esher), 2021-12, Vol.75 (12), p.e14803-n/a</ispartof><rights>2021 John Wiley & Sons Ltd</rights><rights>2021 John Wiley & Sons Ltd.</rights><rights>Copyright © 2021 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3933-d4a7312090a162676da1b42a3d6b90c5c13c79d92bf3227a87027b240d14c67a3</citedby><cites>FETCH-LOGICAL-c3933-d4a7312090a162676da1b42a3d6b90c5c13c79d92bf3227a87027b240d14c67a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijcp.14803$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijcp.14803$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34487384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amini, Mohammad Reza</creatorcontrib><creatorcontrib>Talebyan, Alireza</creatorcontrib><creatorcontrib>Payandeh, Nastaran</creatorcontrib><creatorcontrib>Sheikhhossein, Fatemeh</creatorcontrib><creatorcontrib>Mohtashaminia, Fatemeh</creatorcontrib><creatorcontrib>Gholami, Fatemeh</creatorcontrib><title>The effects of capsinoids and fermented red pepper paste supplementation on Glycaemic Control: A systematic review and meta‐analysis of randomised controlled trials</title><title>International journal of clinical practice (Esher)</title><addtitle>Int J Clin Pract</addtitle><description>Objective
The present systematic review and meta‐analysis were conducted to investigate the effects of capsinoids supplementation on glycaemic control.
Methods
Relevant studies, published up to May 2020, were searched through PubMed/Medline, Scopus, ISI Web of Science, Embase and Google Scholar. All randomised clinical trials investigating the effect of capsinoids supplementation on glycaemic control were included.
Results
Of 326 citations, eight trials with nine effect sizes that enrolled 530 subjects were included. Capsinoids and red pepper resulted in no significant reduction in glucose (Weighted mean differences (WMD): −0.27 mg/dL; 95% CI: −1.9 to 1.37, P = .75), insulin (WMD: −0.09 µU/mL; 95% CI: −1.76 to 1.57, P = .913), homeostatic model assessment for insulin resistance (HOMA‐IR) (WMD: 0.52; 95% CI: −0.29 to 1.32, P = .208) and haemoglobin A1C (HbA1C) (WMD: 0.01%; 95% CI: −0.04 to 0.05, P = .712). Greater effects on glucose were detected in trials performed on both gender, using red pepper, lasted ≥12 weeks, and participants aged >40 years old and recruited greater sample size >50. Insulin and HOMA‐IR were reduced by using red pepper.
Conclusion
Overall, these data suggest that capsinoids and red pepper supplementation did not have beneficial effects on glucose, insulin, HbA1C and HOMA‐IR but significantly reduce glucose in people older than 40 years.</description><subject>Adult</subject><subject>Blood Glucose</subject><subject>Capsicum</subject><subject>Clinical trials</subject><subject>Dietary Supplements</subject><subject>Fermented food</subject><subject>Glucose</subject><subject>Glycated Hemoglobin A</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Meta-analysis</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Supplements</subject><subject>Systematic review</subject><issn>1368-5031</issn><issn>1742-1241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9u1TAQxi1ERcuDDQdAltggpBT_i52wq55KW1QJFmUdOfZE-CmJjZ20yo4j9BQcjJPU76WwYFHL1ozs33xj-0PoDSWnNI-PbmfCKRUV4c_QCVWCFZQJ-jznXFZFSTg9Ri9T2hHCyrIiL9AxF6JSvBIn6PfND8DQdWCmhH2HjQ7Jjd7ZhPVocQdxgHECi2NeAUKAiINOE-A0h9DD_lRPzo84z4t-MRoGZ_DWj1P0_Sd8htOS6SEzJmvcOrg7CA8w6T-_7vWo-yW5Q-uY9_3gUm5k1vI-p1N0uk-v0FGXA7x-jBv0_fP5zfayuP56cbU9uy4MrzkvrNCKU0ZqoqlkUkmraSuY5la2NTGlodyo2tas7ThjSleKMNUyQSwVRirNN-j9qhui_zlDmpp8IQN9r0fwc2pYKWtJZVWrjL77D935Oeb3ZEpSUVdU5K_foA8rZaJPKULXhOgGHZeGkmbvXrN3rzm4l-G3j5JzO4D9h_61KwN0Be5cD8sTUs3Vl-23VfQBuzun_A</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Amini, Mohammad Reza</creator><creator>Talebyan, Alireza</creator><creator>Payandeh, Nastaran</creator><creator>Sheikhhossein, Fatemeh</creator><creator>Mohtashaminia, Fatemeh</creator><creator>Gholami, Fatemeh</creator><general>Hindawi Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>202112</creationdate><title>The effects of capsinoids and fermented red pepper paste supplementation on Glycaemic Control: A systematic review and meta‐analysis of randomised controlled trials</title><author>Amini, Mohammad Reza ; Talebyan, Alireza ; Payandeh, Nastaran ; Sheikhhossein, Fatemeh ; Mohtashaminia, Fatemeh ; Gholami, Fatemeh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3933-d4a7312090a162676da1b42a3d6b90c5c13c79d92bf3227a87027b240d14c67a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Blood Glucose</topic><topic>Capsicum</topic><topic>Clinical trials</topic><topic>Dietary Supplements</topic><topic>Fermented food</topic><topic>Glucose</topic><topic>Glycated Hemoglobin A</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin Resistance</topic><topic>Meta-analysis</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Supplements</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amini, Mohammad Reza</creatorcontrib><creatorcontrib>Talebyan, Alireza</creatorcontrib><creatorcontrib>Payandeh, Nastaran</creatorcontrib><creatorcontrib>Sheikhhossein, Fatemeh</creatorcontrib><creatorcontrib>Mohtashaminia, Fatemeh</creatorcontrib><creatorcontrib>Gholami, Fatemeh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical practice (Esher)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amini, Mohammad Reza</au><au>Talebyan, Alireza</au><au>Payandeh, Nastaran</au><au>Sheikhhossein, Fatemeh</au><au>Mohtashaminia, Fatemeh</au><au>Gholami, Fatemeh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of capsinoids and fermented red pepper paste supplementation on Glycaemic Control: A systematic review and meta‐analysis of randomised controlled trials</atitle><jtitle>International journal of clinical practice (Esher)</jtitle><addtitle>Int J Clin Pract</addtitle><date>2021-12</date><risdate>2021</risdate><volume>75</volume><issue>12</issue><spage>e14803</spage><epage>n/a</epage><pages>e14803-n/a</pages><issn>1368-5031</issn><eissn>1742-1241</eissn><abstract>Objective
The present systematic review and meta‐analysis were conducted to investigate the effects of capsinoids supplementation on glycaemic control.
Methods
Relevant studies, published up to May 2020, were searched through PubMed/Medline, Scopus, ISI Web of Science, Embase and Google Scholar. All randomised clinical trials investigating the effect of capsinoids supplementation on glycaemic control were included.
Results
Of 326 citations, eight trials with nine effect sizes that enrolled 530 subjects were included. Capsinoids and red pepper resulted in no significant reduction in glucose (Weighted mean differences (WMD): −0.27 mg/dL; 95% CI: −1.9 to 1.37, P = .75), insulin (WMD: −0.09 µU/mL; 95% CI: −1.76 to 1.57, P = .913), homeostatic model assessment for insulin resistance (HOMA‐IR) (WMD: 0.52; 95% CI: −0.29 to 1.32, P = .208) and haemoglobin A1C (HbA1C) (WMD: 0.01%; 95% CI: −0.04 to 0.05, P = .712). Greater effects on glucose were detected in trials performed on both gender, using red pepper, lasted ≥12 weeks, and participants aged >40 years old and recruited greater sample size >50. Insulin and HOMA‐IR were reduced by using red pepper.
Conclusion
Overall, these data suggest that capsinoids and red pepper supplementation did not have beneficial effects on glucose, insulin, HbA1C and HOMA‐IR but significantly reduce glucose in people older than 40 years.</abstract><cop>England</cop><pub>Hindawi Limited</pub><pmid>34487384</pmid><doi>10.1111/ijcp.14803</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of clinical practice (Esher), 2021-12, Vol.75 (12), p.e14803-n/a |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Adult Blood Glucose Capsicum Clinical trials Dietary Supplements Fermented food Glucose Glycated Hemoglobin A Hemoglobin Humans Insulin Insulin Resistance Meta-analysis Randomized Controlled Trials as Topic Supplements Systematic review |
| title | The effects of capsinoids and fermented red pepper paste supplementation on Glycaemic Control: A systematic review and meta‐analysis of randomised controlled trials |
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