Non‐negative blind deconvolution for signal processing in a CRISPR‐edited iPSC‐cardiomyocyte model of dilated cardiomyopathy

We developed an integrated platform for analysis of parameterized data from human disease models. We report a non‐negative blind deconvolution (NNBD) approach to quantify calcium (Ca2+) handling, beating force and contractility in human‐induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs)...

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Veröffentlicht in:	FEBS letters 2021-10, Vol.595 (20), p.2544-2557
Hauptverfasser:	Xu, Hang, Wali, Ruheen, Cheruiyot, Cleophas, Bodenschatz, Jonathan, Hasenfuss, Gerd, Janshoff, Andreas, Habeck, Michael, Ebert, Antje
Format:	Artikel
Sprache:	eng
Schlagworte:	atomic force microscopy cardiovascular disease contractility dilated cardiomyopathy human‐induced pluripotent stem cell‐derived cardiomyocytes microdomains signal transduction
Online-Zugang:	Volltext
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