Crizotinib‐induced anti‐cancer activity in human cervical carcinoma cells via ROS‐dependent mitochondrial depolarization and induction of apoptotic pathway

Introduction Cervical cancer is one of the leading causes of mortality among women population worldwide. In spite of recurrent screening, vaccination, and chemotherapeutic interventions, combating cervical cancer still remains a challenge. Crizotinib is a small molecule inhibitor that targets mesenc...

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Veröffentlicht in:	The journal of obstetrics and gynaecology research 2021-11, Vol.47 (11), p.3923-3930
Hauptverfasser:	Varma, Diksha A., Tiwari, Manisha
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Breast Breast cancer Breast carcinoma Cell activation Cell cycle Cell proliferation Cervical cancer Cervical carcinoma Cervix crizotinib Cytotoxicity Depolarization Flow cytometry Fluorescein isothiocyanate Labeling Membrane potential Mesenchyme Mitochondria Molecular modelling Non-small cell lung carcinoma Pancreatic cancer Prostate cancer Prostate carcinoma Reactive oxygen species ROS Targeted cancer therapy Therapeutic targets Vaccination
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