Modulating tumor-associated macrophages to enhance the efficacy of immune checkpoint inhibitors: A TAM-pting approach

Tumor-associated macrophages (TAM) plasticity and diversity are both essential hallmarks of the monocyte-macrophage lineage and the tumor-derived inflammation. TAM exemplify the perfect adaptable cell with dynamic phenotypic modifications that reflect changes in their functional polarization status....

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Veröffentlicht in:	Pharmacology & therapeutics (Oxford) 2022-03, Vol.231, p.107986-107986, Article 107986
Hauptverfasser:	Chamseddine, Ali N., Assi, Tarek, Mir, Olivier, Chouaib, Salem
Format:	Artikel
Sprache:	eng
Schlagworte:	Humans ICI (immune checkpoint inhibitors) Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use Immunotherapy Macrophage Neoplasms - pathology TAM (tumor-associated macrophages) TME (tumor microenvironment) Tumor Microenvironment Tumor-Associated Macrophages
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