A multifunctional nanodiamond-based nanoplatform for the enhanced mild-temperature photothermal/chemo combination therapy of triple negative breast cancer via an autophagy regulation strategy
Owing to its aggressive biological behavior, the lack of specific targets, and the strong therapeutic resistance of triple negative breast cancer (TNBC), current therapeutic strategies are still limited. The combination of multiple treatments has been confirmed as a promising strategy for TNBC thera...
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| Veröffentlicht in: | Nanoscale 2021-08, Vol.13 (31), p.13375-13389 |
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| creator | Cui, Xinyue Liang, Zhaoyuan Lu, Jianqing Wang, Xuan Jia, Fan Hu, Qin Xiao, Xiangqian Deng, Xiongwei Wu, Yan Sheng, Wang |
| description | Owing to its aggressive biological behavior, the lack of specific targets, and the strong therapeutic resistance of triple negative breast cancer (TNBC), current therapeutic strategies are still limited. The combination of multiple treatments has been confirmed as a promising strategy for TNBC therapy. However, the efficacy of combination therapy can be restricted due to increasing therapeutic resistance to various treatments. Herein, we constructed a nanodiamond (ND)-based nanoplatform for augmented mild-temperature photothermal/chemo combination therapy against TNBC, weakening the therapeutic resistance
via
autophagy inhibition enabled by the NDs. A layer-by-layer self-assembly approach was utilized to construct the ND-based nanoplatform. First, the NDs were modified with protamine sulphate (PS). Meanwhile, the photosensitizer indocyanine green (ICG) and the HSP70 small molecule inhibitor apoptozole (APZ) could be synchronously incorporated to form positively charged PS@ND (ICG + APZ). Then negatively charged hyaluronic acid (HA) was assembled onto the outer face of PS@ND (ICG + APZ) to form the NPIAs. Finally, the positively charged small molecule anti-cancer drug doxorubicin (DOX) could be adsorbed onto the surface of the NPIAs through electrostatic interactions (NPIADs). The resulting NPIADs could be triggered by NIR laser irradiation to exhibit enhanced mild-temperature photothermal therapy (PTT) effects
via
suppressing the expression of HSP70, and PTT combined with chemotherapy could further enhance the anti-tumor efficacy. Subsequently, the sensitivity of MDA-MB-231 cells could be significantly improved through the weakening of the thermal/drug resistance
via
autophagy inhibition, leading to augmented combination therapy that is efficient both
in vitro
and
in vivo
. Furthermore, the NPIADs could be used as a theranostic nanoplatform for fluorescence (FL) and photoacoustic (PA) imaging. Taken together, this study demonstrated a multifunctional ND-based nanoplatform for FL/PA imaging-guided augmented mild-temperature photothermal/chemo combination therapy
via
an autophagy regulation strategy against TNBC. |
| doi_str_mv | 10.1039/d1nr03161a |
| format | Article |
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via
autophagy inhibition enabled by the NDs. A layer-by-layer self-assembly approach was utilized to construct the ND-based nanoplatform. First, the NDs were modified with protamine sulphate (PS). Meanwhile, the photosensitizer indocyanine green (ICG) and the HSP70 small molecule inhibitor apoptozole (APZ) could be synchronously incorporated to form positively charged PS@ND (ICG + APZ). Then negatively charged hyaluronic acid (HA) was assembled onto the outer face of PS@ND (ICG + APZ) to form the NPIAs. Finally, the positively charged small molecule anti-cancer drug doxorubicin (DOX) could be adsorbed onto the surface of the NPIAs through electrostatic interactions (NPIADs). The resulting NPIADs could be triggered by NIR laser irradiation to exhibit enhanced mild-temperature photothermal therapy (PTT) effects
via
suppressing the expression of HSP70, and PTT combined with chemotherapy could further enhance the anti-tumor efficacy. Subsequently, the sensitivity of MDA-MB-231 cells could be significantly improved through the weakening of the thermal/drug resistance
via
autophagy inhibition, leading to augmented combination therapy that is efficient both
in vitro
and
in vivo
. Furthermore, the NPIADs could be used as a theranostic nanoplatform for fluorescence (FL) and photoacoustic (PA) imaging. Taken together, this study demonstrated a multifunctional ND-based nanoplatform for FL/PA imaging-guided augmented mild-temperature photothermal/chemo combination therapy
via
an autophagy regulation strategy against TNBC.</description><identifier>ISSN: 2040-3364</identifier><identifier>EISSN: 2040-3372</identifier><identifier>DOI: 10.1039/d1nr03161a</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Anticancer properties ; Autophagy ; Breast cancer ; Cancer therapies ; Diamonds ; Doxorubicin ; Fluorescence ; Hyaluronic acid ; Nanostructure ; Self-assembly ; Thermal resistance</subject><ispartof>Nanoscale, 2021-08, Vol.13 (31), p.13375-13389</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c292t-1bed7a0c8f0ac273d7f333cfcf3b68794a1b7f60eefea98727624e6d514398a73</citedby><cites>FETCH-LOGICAL-c292t-1bed7a0c8f0ac273d7f333cfcf3b68794a1b7f60eefea98727624e6d514398a73</cites><orcidid>0000-0001-8508-7077 ; 0000-0003-4042-5102</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids></links><search><creatorcontrib>Cui, Xinyue</creatorcontrib><creatorcontrib>Liang, Zhaoyuan</creatorcontrib><creatorcontrib>Lu, Jianqing</creatorcontrib><creatorcontrib>Wang, Xuan</creatorcontrib><creatorcontrib>Jia, Fan</creatorcontrib><creatorcontrib>Hu, Qin</creatorcontrib><creatorcontrib>Xiao, Xiangqian</creatorcontrib><creatorcontrib>Deng, Xiongwei</creatorcontrib><creatorcontrib>Wu, Yan</creatorcontrib><creatorcontrib>Sheng, Wang</creatorcontrib><title>A multifunctional nanodiamond-based nanoplatform for the enhanced mild-temperature photothermal/chemo combination therapy of triple negative breast cancer via an autophagy regulation strategy</title><title>Nanoscale</title><description>Owing to its aggressive biological behavior, the lack of specific targets, and the strong therapeutic resistance of triple negative breast cancer (TNBC), current therapeutic strategies are still limited. The combination of multiple treatments has been confirmed as a promising strategy for TNBC therapy. However, the efficacy of combination therapy can be restricted due to increasing therapeutic resistance to various treatments. Herein, we constructed a nanodiamond (ND)-based nanoplatform for augmented mild-temperature photothermal/chemo combination therapy against TNBC, weakening the therapeutic resistance
via
autophagy inhibition enabled by the NDs. A layer-by-layer self-assembly approach was utilized to construct the ND-based nanoplatform. First, the NDs were modified with protamine sulphate (PS). Meanwhile, the photosensitizer indocyanine green (ICG) and the HSP70 small molecule inhibitor apoptozole (APZ) could be synchronously incorporated to form positively charged PS@ND (ICG + APZ). Then negatively charged hyaluronic acid (HA) was assembled onto the outer face of PS@ND (ICG + APZ) to form the NPIAs. Finally, the positively charged small molecule anti-cancer drug doxorubicin (DOX) could be adsorbed onto the surface of the NPIAs through electrostatic interactions (NPIADs). The resulting NPIADs could be triggered by NIR laser irradiation to exhibit enhanced mild-temperature photothermal therapy (PTT) effects
via
suppressing the expression of HSP70, and PTT combined with chemotherapy could further enhance the anti-tumor efficacy. Subsequently, the sensitivity of MDA-MB-231 cells could be significantly improved through the weakening of the thermal/drug resistance
via
autophagy inhibition, leading to augmented combination therapy that is efficient both
in vitro
and
in vivo
. Furthermore, the NPIADs could be used as a theranostic nanoplatform for fluorescence (FL) and photoacoustic (PA) imaging. Taken together, this study demonstrated a multifunctional ND-based nanoplatform for FL/PA imaging-guided augmented mild-temperature photothermal/chemo combination therapy
via
an autophagy regulation strategy against TNBC.</description><subject>Anticancer properties</subject><subject>Autophagy</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Diamonds</subject><subject>Doxorubicin</subject><subject>Fluorescence</subject><subject>Hyaluronic acid</subject><subject>Nanostructure</subject><subject>Self-assembly</subject><subject>Thermal resistance</subject><issn>2040-3364</issn><issn>2040-3372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkduKFDEQhhtRcF298QkC3ojQbg49SfflsK4HWBREr5vqdGU6Sw5tkl6Yp_PVzMyIF95UFVVf_QV_Nc1rRt8zKoabmYVEBZMMnjRXnHa0FULxp_9q2T1vXuT8QKkchBRXze898Zsr1mxBFxsDOBIgxNmCj2FuJ8g4nzurg2Ji8qQGUhYkGBYIuk69dXNb0K-YoGwJybrEEiuSPLgbvaCPREc_2QCnC6flBOuRRENKsqtDEvBQR49IpoSQC9En4UQeLRAIBLYS1wUOR5LwsLmLSC71GB6OL5tnBlzGV3_zdfPz492P28_t_bdPX273963mAy8tm3BWQHVvKGiuxKyMEEIbbcQkezV0wCZlJEU0CEOvuJK8QznvWCeGHpS4bt5edNcUf22Yy-ht1ugcBIxbHvmuGtoLSfuKvvkPfYhbqs6eKcp3bBh4pd5dKJ1izgnNuCbrIR1HRsfTL8cP7Ov38y_34g8jL5fV</recordid><startdate>20210821</startdate><enddate>20210821</enddate><creator>Cui, Xinyue</creator><creator>Liang, Zhaoyuan</creator><creator>Lu, Jianqing</creator><creator>Wang, Xuan</creator><creator>Jia, Fan</creator><creator>Hu, Qin</creator><creator>Xiao, Xiangqian</creator><creator>Deng, Xiongwei</creator><creator>Wu, Yan</creator><creator>Sheng, Wang</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8508-7077</orcidid><orcidid>https://orcid.org/0000-0003-4042-5102</orcidid></search><sort><creationdate>20210821</creationdate><title>A multifunctional nanodiamond-based nanoplatform for the enhanced mild-temperature photothermal/chemo combination therapy of triple negative breast cancer via an autophagy regulation strategy</title><author>Cui, Xinyue ; Liang, Zhaoyuan ; Lu, Jianqing ; Wang, Xuan ; Jia, Fan ; Hu, Qin ; Xiao, Xiangqian ; Deng, Xiongwei ; Wu, Yan ; Sheng, Wang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-1bed7a0c8f0ac273d7f333cfcf3b68794a1b7f60eefea98727624e6d514398a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anticancer properties</topic><topic>Autophagy</topic><topic>Breast cancer</topic><topic>Cancer therapies</topic><topic>Diamonds</topic><topic>Doxorubicin</topic><topic>Fluorescence</topic><topic>Hyaluronic acid</topic><topic>Nanostructure</topic><topic>Self-assembly</topic><topic>Thermal resistance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cui, Xinyue</creatorcontrib><creatorcontrib>Liang, Zhaoyuan</creatorcontrib><creatorcontrib>Lu, Jianqing</creatorcontrib><creatorcontrib>Wang, Xuan</creatorcontrib><creatorcontrib>Jia, Fan</creatorcontrib><creatorcontrib>Hu, Qin</creatorcontrib><creatorcontrib>Xiao, Xiangqian</creatorcontrib><creatorcontrib>Deng, Xiongwei</creatorcontrib><creatorcontrib>Wu, Yan</creatorcontrib><creatorcontrib>Sheng, Wang</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Nanoscale</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cui, Xinyue</au><au>Liang, Zhaoyuan</au><au>Lu, Jianqing</au><au>Wang, Xuan</au><au>Jia, Fan</au><au>Hu, Qin</au><au>Xiao, Xiangqian</au><au>Deng, Xiongwei</au><au>Wu, Yan</au><au>Sheng, Wang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A multifunctional nanodiamond-based nanoplatform for the enhanced mild-temperature photothermal/chemo combination therapy of triple negative breast cancer via an autophagy regulation strategy</atitle><jtitle>Nanoscale</jtitle><date>2021-08-21</date><risdate>2021</risdate><volume>13</volume><issue>31</issue><spage>13375</spage><epage>13389</epage><pages>13375-13389</pages><issn>2040-3364</issn><eissn>2040-3372</eissn><abstract>Owing to its aggressive biological behavior, the lack of specific targets, and the strong therapeutic resistance of triple negative breast cancer (TNBC), current therapeutic strategies are still limited. The combination of multiple treatments has been confirmed as a promising strategy for TNBC therapy. However, the efficacy of combination therapy can be restricted due to increasing therapeutic resistance to various treatments. Herein, we constructed a nanodiamond (ND)-based nanoplatform for augmented mild-temperature photothermal/chemo combination therapy against TNBC, weakening the therapeutic resistance
via
autophagy inhibition enabled by the NDs. A layer-by-layer self-assembly approach was utilized to construct the ND-based nanoplatform. First, the NDs were modified with protamine sulphate (PS). Meanwhile, the photosensitizer indocyanine green (ICG) and the HSP70 small molecule inhibitor apoptozole (APZ) could be synchronously incorporated to form positively charged PS@ND (ICG + APZ). Then negatively charged hyaluronic acid (HA) was assembled onto the outer face of PS@ND (ICG + APZ) to form the NPIAs. Finally, the positively charged small molecule anti-cancer drug doxorubicin (DOX) could be adsorbed onto the surface of the NPIAs through electrostatic interactions (NPIADs). The resulting NPIADs could be triggered by NIR laser irradiation to exhibit enhanced mild-temperature photothermal therapy (PTT) effects
via
suppressing the expression of HSP70, and PTT combined with chemotherapy could further enhance the anti-tumor efficacy. Subsequently, the sensitivity of MDA-MB-231 cells could be significantly improved through the weakening of the thermal/drug resistance
via
autophagy inhibition, leading to augmented combination therapy that is efficient both
in vitro
and
in vivo
. Furthermore, the NPIADs could be used as a theranostic nanoplatform for fluorescence (FL) and photoacoustic (PA) imaging. Taken together, this study demonstrated a multifunctional ND-based nanoplatform for FL/PA imaging-guided augmented mild-temperature photothermal/chemo combination therapy
via
an autophagy regulation strategy against TNBC.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d1nr03161a</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-8508-7077</orcidid><orcidid>https://orcid.org/0000-0003-4042-5102</orcidid></addata></record> |
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| ispartof | Nanoscale, 2021-08, Vol.13 (31), p.13375-13389 |
| issn | 2040-3364 2040-3372 |
| language | eng |
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| source | Royal Society Of Chemistry Journals |
| subjects | Anticancer properties Autophagy Breast cancer Cancer therapies Diamonds Doxorubicin Fluorescence Hyaluronic acid Nanostructure Self-assembly Thermal resistance |
| title | A multifunctional nanodiamond-based nanoplatform for the enhanced mild-temperature photothermal/chemo combination therapy of triple negative breast cancer via an autophagy regulation strategy |
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