Alkylation of 5‑Substituted 1H‑Tetrazoles via the Diazotization of Aliphatic Amines

A new alkylation reaction of monosubstituted tetrazoles via the diazotization of aliphatic amines is reported. This method enables preferential formation of 2,5-disubstituted tetrazoles. A one-pot 1,3-dipolar cycloaddition/diazotization sequence starting from widely available nitriles is also descri...

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Veröffentlicht in:	Journal of organic chemistry 2021-09, Vol.86 (17), p.12452-12459
Hauptverfasser:	Reynard, Guillaume, Lebel, Hélène
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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