Co-operative binding of SKP1, Cullin1 and Cullin7 to FBXW8 results in Cullin1-SKP1-FBXW8-Cullin7 functional complex formation that monitors cellular function of β-TrCP1

F-box protein FBXW8 is known to interact with scaffolding protein Cullin1 and Cullin7 to form SCF (SKP1, Cullin and F-box protein) complex. However, detail understanding about the importance of both Cullins for SCF-FBXW8 complex formation as well as its ubiquitin ligase activity remains elusive. Her...

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Veröffentlicht in:	International journal of biological macromolecules 2021-11, Vol.190, p.233-243
Hauptverfasser:	Islam, Sehbanul, Dutta, Parul, Chopra, Kriti, Sahay, Osheen, Rapole, Srikanth, Chauhan, Radha, Santra, Manas Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	beta Catenin - metabolism beta-Transducin Repeat-Containing Proteins - chemistry beta-Transducin Repeat-Containing Proteins - metabolism Cell migration Cell Movement Co-operative binding Cullin Proteins - chemistry Cullin Proteins - metabolism F-box protein F-Box Proteins - chemistry F-Box Proteins - metabolism Gel filtration Humans MCF-7 Cells Multiprotein Complexes - metabolism Protein Binding Protein Stability Proteolysis S-Phase Kinase-Associated Proteins - chemistry S-Phase Kinase-Associated Proteins - metabolism SCF complex Substrate Specificity
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