Long intragenic non-coding RNA p53-induced transcript (LINC-PINT) as a novel prognosis indicator and therapeutic target in cancer
Cancer involves complex etiology factors, multiple stages, and intricate gene mutations. Long non-coding RNAs (lncRNAs) are implicated as molecular mechanisms underlying human genomic activity in various physiologic and pathophysiologic conditions. However, the sophisticated modifications and regula...
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| Veröffentlicht in: | Biomedicine & pharmacotherapy 2021-11, Vol.143, p.112127-112127, Article 112127 |
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| creator | He, Tiefei Yuan, Chendong Zhao, Cansong |
| description | Cancer involves complex etiology factors, multiple stages, and intricate gene mutations. Long non-coding RNAs (lncRNAs) are implicated as molecular mechanisms underlying human genomic activity in various physiologic and pathophysiologic conditions. However, the sophisticated modifications and regulatory processes linking lncRNAs to cancer initiation and progression have not yet been fully explored. Long intragenic non-coding RNA p53-induced transcript (LINC-PINT) is an lncRNA that functions as a tumor suppressor gene involved in various tumors and malignant activities. LINC-PINT is downregulated in nasopharyngeal cancer, renal carcinoma, non-small cell lung cancer, glioblastoma, thyroid cancer, retinoblastoma, ovarian cancer, breast cancer, esophageal squamous cell carcinoma, osteosarcoma, melanoma, and gastric cancer. Furthermore, decreased LINC-PINT expression predicts poor prognosis and advanced clinical tumor stages. Together, these studies indicate that LINC-PINT could serve as a diagnostic and prognostic indicator in cancer. The specific lncRNA regulatory mechanism of LINC-PINT may also be a novel target for cancer therapies. |
| doi_str_mv | 10.1016/j.biopha.2021.112127 |
| format | Article |
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The specific lncRNA regulatory mechanism of LINC-PINT may also be a novel target for cancer therapies.</description><subject>Animals</subject><subject>Biomarker</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cancer</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>LINC-PINT</subject><subject>LncRNA</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - therapy</subject><subject>Prognosis</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Signal Transduction</subject><subject>Tumor suppressor gene</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1qGzEURkVpaNy0b1CKlulinKufkexNIZi0MRinlHQtZM0dR8aWppIm0GXfPAqTdFltBOJ839U9hHxiMGfA1NVhvvNxeLBzDpzNGeOM6zdkxpYtNApAvyUz0K1ohOD8nLzP-QAArRKLd-RcSKmlkHxG_m5i2FMfSrJ7DN7REEPjYufr68_tNR1qgw_d6LCjlQnZJT8UerlZb1fNj_X2_gu1mdoae8QjHVLch5h9ro2dd7bERG2oyQdMdsCx1AHFpj2WClBng8P0gZz19pjx48t9QX59u7lf3Tabu-_r1fWmcRIWpVHKLjQsWt3vUCNYp5eKtSB3KJ3uVe-AMet429u6mV72EpSup9eAWjtlxQW5nHrrJ3-PmIs5-ezweLQB45gNb9VSaKWYqKicUJdizgl7MyR_sumPYWCe5ZuDmeSbZ_lmkl9jn18mjLsTdv9Cr7Yr8HUCsO756DGZ7DxWCZ1P6Irpov__hCfIA5a7</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>He, Tiefei</creator><creator>Yuan, Chendong</creator><creator>Zhao, Cansong</creator><general>Elsevier Masson SAS</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202111</creationdate><title>Long intragenic non-coding RNA p53-induced transcript (LINC-PINT) as a novel prognosis indicator and therapeutic target in cancer</title><author>He, Tiefei ; Yuan, Chendong ; Zhao, Cansong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-66a870857fbe7e0ac7961504be4c7f6fc011ac25fa74379f4067777f70e77c6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Biomarker</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cancer</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>LINC-PINT</topic><topic>LncRNA</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - therapy</topic><topic>Prognosis</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>Signal Transduction</topic><topic>Tumor suppressor gene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Tiefei</creatorcontrib><creatorcontrib>Yuan, Chendong</creatorcontrib><creatorcontrib>Zhao, Cansong</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedicine & pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Tiefei</au><au>Yuan, Chendong</au><au>Zhao, Cansong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long intragenic non-coding RNA p53-induced transcript (LINC-PINT) as a novel prognosis indicator and therapeutic target in cancer</atitle><jtitle>Biomedicine & pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>2021-11</date><risdate>2021</risdate><volume>143</volume><spage>112127</spage><epage>112127</epage><pages>112127-112127</pages><artnum>112127</artnum><issn>0753-3322</issn><eissn>1950-6007</eissn><abstract>Cancer involves complex etiology factors, multiple stages, and intricate gene mutations. 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| subjects | Animals Biomarker Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Gene Expression Regulation, Neoplastic Humans LINC-PINT LncRNA Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neoplasms - therapy Prognosis RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Signal Transduction Tumor suppressor gene |
| title | Long intragenic non-coding RNA p53-induced transcript (LINC-PINT) as a novel prognosis indicator and therapeutic target in cancer |
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