Infant RSV immunoprophylaxis changes nasal epithelial DNA methylation at 6 years of age

Background Respiratory syncytial virus (RSV) infection has been associated with childhood wheeze and asthma, and potential mechanisms include persistent epigenetic effects. Methods In the randomized, placebo‐controlled MAKI trial, 429 preterm infants randomly received RSV immunoprophylaxis with pali...

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Veröffentlicht in:	Pediatric pulmonology 2021-12, Vol.56 (12), p.3822-3831
Hauptverfasser:	Xu, Cheng‐Jian, Scheltema, Nienke M., Qi, Cancan, Vedder, Rolf, Klein, Laura B. C., Nibbelke, Elisabeth E., Ent, Cornelis K., Bont, Louis J., Koppelman, Gerard H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Antiviral Agents - therapeutic use Asthma Child DNA Methylation Epigenetics Hospitalization Humans Infant Infant, Newborn Infant, Premature Palivizumab - therapeutic use Respiratory syncytial virus Respiratory Syncytial Virus Infections - drug therapy Respiratory Syncytial Virus Infections - prevention & control RSV immunoprophylaxis RSV infection Sensory perception
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