Downregulated fat mass and obesity-associated protein inhibits bone resorption and osteoclastogenesis by nuclear factor-kappa B inactivation

During osteoporosis, fat mass and obesity-associated protein (FTO) promotes the shift of bone marrow mesenchymal stem cells to adipocytes and represses osteoblast activity. However, the role and mechanisms of FTO on osteoclast formation and bone resorption remain unknown. In this study, we investiga...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cellular signalling 2021-11, Vol.87, p.110137-110137, Article 110137
Hauptverfasser:	Zhuang, Jinpeng, Ning, Hua, Wang, Maoqing, Zhao, Wei, Jing, Yongbin, Liu, Xiaoqi, Zu, Jianing, Kong, Pengyu, Wang, Xiaoyan, Sun, Changhao, Yan, Jinglong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone resorption Bone Resorption - metabolism Cell Differentiation Fat mass and obesity-associated protein Mice NF-kappa B - metabolism NFATC Transcription Factors - metabolism Nuclear factor-kappa B Obesity - metabolism Osteoclastogenesis Osteoclasts - metabolism Osteogenesis Osteoporosis RANK Ligand - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!