Mechanisms of irreversible aquaporin-10 inhibition by organogold compounds studied by combined biophysical methods and atomistic simulations

The inhibition of glycerol permeation via human aquaporin-10 (hAQP10) by organometallic gold complexes has been studied by stopped-flow fluorescence spectroscopy, and its mechanism has been described using molecular modelling and atomistic simulations. The most effective hAQP10 inhibitors are cyclom...

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Veröffentlicht in:	Metallomics 2021-09, Vol.13 (9)
Hauptverfasser:	Pimpão, Catarina, Wragg, Darren, Bonsignore, Riccardo, Aikman, Brech, Pedersen, Per Amstrup, Leoni, Stefano, Soveral, Graça, Casini, Angela
Format:	Artikel
Sprache:	eng
Schlagworte:	Aquaporins - antagonists & inhibitors Biophysical Phenomena Humans Molecular Dynamics Simulation Organogold Compounds - pharmacology Spectrometry, Fluorescence - methods
Online-Zugang:	Volltext
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