Involvement of 4-hydroxy-2-nonenal in the pathogenesis of pulmonary fibrosis

Pulmonary fibrosis is a chronic progressive disease with high incidence, prevalence, and mortality rates worldwide. It is characterized by excessive accumulation of extracellular matrix in the lung parenchyma. The cellular and molecular mechanisms involved in its pathogenesis are complex, and some a...

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Veröffentlicht in:	Molecular and cellular biochemistry 2021-12, Vol.476 (12), p.4405-4419
Hauptverfasser:	Reyes-Jiménez, Edilburga, Ramírez-Hernández, Alma Aurora, Santos-Álvarez, Jovito Cesar, Velázquez-Enríquez, Juan Manuel, Pina-Canseco, Socorro, Baltiérrez-Hoyos, Rafael, Vásquez-Garzón, Verónica Rocío
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - metabolism Alveoli Animals Apoptosis - physiology Biochemistry Biomedical and Life Sciences Cardiology Cellular signal transduction Endothelial cells Extracellular matrix Fatty acids Fibrosis Health aspects Humans Inflammation Inflammation - immunology Inflammation - metabolism Inflammation - pathology Life Sciences Lipid Peroxidation Lipids Lung - metabolism Lung - pathology Lung diseases Macrophages Maintenance Medical Biochemistry Molecular modelling Mortality Nucleic acids Oncology Oxidative stress Oxidative Stress - physiology Parenchyma Pathogenesis Phospholipids Polyunsaturated fatty acids Prevalence studies (Epidemiology) Proteins Pulmonary fibrosis Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Reactive oxygen species Reactive Oxygen Species - metabolism Signal Transduction Unsaturated fatty acids
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