Discovery of new human Sirtuin 5 inhibitors by mimicking glutaryl-lysine substrates

Human sirtuin 5 (SIRT5) plays pivotal roles in metabolic pathways and other biological processes, and is involved in several human diseases including cancer. Development of new potent and selective SIRT5 inhibitors is currently desirable to provide potential therapeutics for related diseases. Herein...

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Veröffentlicht in:	European journal of medicinal chemistry 2021-12, Vol.225, p.113803-113803, Article 113803
Hauptverfasser:	Yang, Fan, Su, Huilin, Deng, Ji, Mou, Luohe, Wang, Huali, Li, Rong, Dai, Qing-Qing, Yan, Yu-Hang, Qian, Shan, Wang, Zhouyu, Li, Guo-Bo, Yang, Lingling
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry, Medicinal Dose-Response Relationship, Drug Drug Discovery Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Epigenetics Humans Life Sciences & Biomedicine Lysine - antagonists & inhibitors Lysine - metabolism Molecular Structure Pharmacology & Pharmacy Propionates - chemical synthesis Propionates - chemistry Propionates - pharmacology Science & Technology SIRT5 Sirtuins Sirtuins - antagonists & inhibitors Sirtuins - metabolism Structure-Activity Relationship Structure-based optimization Substrate Specificity Substrate-mimicking Thiourea - chemical synthesis Thiourea - chemistry Thiourea - pharmacology
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