Factors Associated With Advanced Colorectal Neoplasia in Patients With CKD
The risk of developing colorectal cancer in patients with chronic kidney disease (CKD) is twice that of the general population, but the factors associated with colorectal cancer are poorly understood. The aim of this study was to identify factors associated with advanced colorectal neoplasia in pati...
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| Veröffentlicht in: | American journal of kidney diseases 2022-04, Vol.79 (4), p.549-560 |
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| creator | Au, Eric H. Wong, Germaine Howard, Kirsten Chapman, Jeremy R. Castells, Antoni Roger, Simon D. Bourke, Michael J. Macaskill, Petra Turner, Robin Lim, Wai H. Lok, Charmaine E. Diekmann, Fritz Cross, Nicholas Sen, Shaundeep Allen, Richard D. Chadban, Steven J. Pollock, Carol A. Tong, Allison Teixeira-Pinto, Armando Yang, Jean Y. Kieu, Anh James, Laura Craig, Jonathan C. |
| description | The risk of developing colorectal cancer in patients with chronic kidney disease (CKD) is twice that of the general population, but the factors associated with colorectal cancer are poorly understood. The aim of this study was to identify factors associated with advanced colorectal neoplasia in patients with CKD.
Prospective cohort study.
Patients with CKD stages 3-5, including those treated with maintenance dialysis or transplantation across 11 sites in Australia, New Zealand, Canada, and Spain, were screened for colorectal neoplasia using a fecal immunochemical test (FIT) as part of the Detecting Bowel Cancer in CKD (DETECT) Study.
Baseline characteristics for patients at the time of study enrollment were ascertained, including duration of CKD, comorbidities, and medications.
Advanced colorectal neoplasia was identified through a 2-step verification process with colonoscopy following positive FIT and 2-year clinical follow-up for all patients.
Potential factors associated with advanced colorectal neoplasia were explored using multivariable logistic regression. Sensitivity analyses were performed using grouped LASSO (least absolute shrinkage and selection operator) logistic regression.
Among 1,706 patients who received FIT-based screening—791 with CKD stages 3-5 not receiving kidney replacement therapy (KRT), 418 receiving dialysis, and 497 patients with a functioning kidney transplant—117 patients (6.9%) were detected to have advanced colorectal neoplasia (54 with CKD stages 3-5 without KRT, 34 receiving dialysis, and 29 transplant recipients), including 9 colorectal cancers. The factors found to be associated with advanced colorectal neoplasia included older age (OR per year older, 1.05 [95% CI, 1.03-1.07], P |
| doi_str_mv | 10.1053/j.ajkd.2021.07.011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2567981053</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0272638621008234</els_id><sourcerecordid>2567981053</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-ccfd28781db8defd5cd5f271af2cd7dfa895bb22ca577e66b91c3cbbd09811163</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EouXxAyxQlmwS_GhsR2JTBcqrAhYglpZjO8IhjYudVuLvcZTCktVopHOvZg4AZwhmCObksslk86kzDDHKIMsgQntginJMUsoJ3wdTiBlOKeF0Ao5CaCCEBaH0EEzIbEYRonwKHhZS9c6HZB6CU1b2Rifvtv9I5norOxW30rXOG9XLNnkybt3KYGViu-RF9tZ0fRjx8vH6BBzUsg3mdDePwdvi5rW8S5fPt_flfJkqktM-VarWmDOOdMW1qXWudF5jhmSNlWa6lrzIqwpjJXPGDKVVgRRRVaVhwVE8mhyDi7F37d3XxoRerGxQpm1lZ9wmCJxTFtFoKKJ4RJV3IXhTi7W3K-m_BYJiIEQjBodicCggE9FhDJ3v-jfVyui_yK-0CFyNgIlfbq3xIqioIsqygyihnf2v_wf2OYKr</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2567981053</pqid></control><display><type>article</type><title>Factors Associated With Advanced Colorectal Neoplasia in Patients With CKD</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Au, Eric H. ; Wong, Germaine ; Howard, Kirsten ; Chapman, Jeremy R. ; Castells, Antoni ; Roger, Simon D. ; Bourke, Michael J. ; Macaskill, Petra ; Turner, Robin ; Lim, Wai H. ; Lok, Charmaine E. ; Diekmann, Fritz ; Cross, Nicholas ; Sen, Shaundeep ; Allen, Richard D. ; Chadban, Steven J. ; Pollock, Carol A. ; Tong, Allison ; Teixeira-Pinto, Armando ; Yang, Jean Y. ; Kieu, Anh ; James, Laura ; Craig, Jonathan C.</creator><creatorcontrib>Au, Eric H. ; Wong, Germaine ; Howard, Kirsten ; Chapman, Jeremy R. ; Castells, Antoni ; Roger, Simon D. ; Bourke, Michael J. ; Macaskill, Petra ; Turner, Robin ; Lim, Wai H. ; Lok, Charmaine E. ; Diekmann, Fritz ; Cross, Nicholas ; Sen, Shaundeep ; Allen, Richard D. ; Chadban, Steven J. ; Pollock, Carol A. ; Tong, Allison ; Teixeira-Pinto, Armando ; Yang, Jean Y. ; Kieu, Anh ; James, Laura ; Craig, Jonathan C.</creatorcontrib><description>The risk of developing colorectal cancer in patients with chronic kidney disease (CKD) is twice that of the general population, but the factors associated with colorectal cancer are poorly understood. The aim of this study was to identify factors associated with advanced colorectal neoplasia in patients with CKD.
Prospective cohort study.
Patients with CKD stages 3-5, including those treated with maintenance dialysis or transplantation across 11 sites in Australia, New Zealand, Canada, and Spain, were screened for colorectal neoplasia using a fecal immunochemical test (FIT) as part of the Detecting Bowel Cancer in CKD (DETECT) Study.
Baseline characteristics for patients at the time of study enrollment were ascertained, including duration of CKD, comorbidities, and medications.
Advanced colorectal neoplasia was identified through a 2-step verification process with colonoscopy following positive FIT and 2-year clinical follow-up for all patients.
Potential factors associated with advanced colorectal neoplasia were explored using multivariable logistic regression. Sensitivity analyses were performed using grouped LASSO (least absolute shrinkage and selection operator) logistic regression.
Among 1,706 patients who received FIT-based screening—791 with CKD stages 3-5 not receiving kidney replacement therapy (KRT), 418 receiving dialysis, and 497 patients with a functioning kidney transplant—117 patients (6.9%) were detected to have advanced colorectal neoplasia (54 with CKD stages 3-5 without KRT, 34 receiving dialysis, and 29 transplant recipients), including 9 colorectal cancers. The factors found to be associated with advanced colorectal neoplasia included older age (OR per year older, 1.05 [95% CI, 1.03-1.07], P<0.001), male sex (OR, 2.27 [95% CI, 1.45-3.54], P<0.001), azathioprine use (OR, 2.99 [95% CI, 1.40-6.37], P=0.005), and erythropoiesis-stimulating agent use (OR, 1.92 [95% CI, 1.22-3.03], P=0.005). Grouped LASSO logistic regression revealed similar associations between these factors and advanced colorectal neoplasia.
Unmeasured confounding factors.
Older age, male sex, erythropoiesis-stimulating agents, and azathioprine were found to be significantly associated with advanced colorectal neoplasia in patients with CKD.</description><identifier>ISSN: 0272-6386</identifier><identifier>EISSN: 1523-6838</identifier><identifier>DOI: 10.1053/j.ajkd.2021.07.011</identifier><identifier>PMID: 34461168</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Azathioprine ; bowel cancer ; chronic kidney disease (CKD) ; Colonoscopy ; colorectal cancer ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - epidemiology ; dialysis ; end-stage renal disease (ESRD) ; epidemiology ; fecal immunochemical test (FIT) ; Feces ; Humans ; Male ; Occult Blood ; Prospective Studies ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - epidemiology ; Renal Insufficiency, Chronic - therapy ; Risk Factors ; transplant recipient</subject><ispartof>American journal of kidney diseases, 2022-04, Vol.79 (4), p.549-560</ispartof><rights>2021 National Kidney Foundation, Inc.</rights><rights>Copyright © 2021 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-ccfd28781db8defd5cd5f271af2cd7dfa895bb22ca577e66b91c3cbbd09811163</citedby><cites>FETCH-LOGICAL-c356t-ccfd28781db8defd5cd5f271af2cd7dfa895bb22ca577e66b91c3cbbd09811163</cites><orcidid>0000-0002-6089-5913</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0272638621008234$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34461168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Au, Eric H.</creatorcontrib><creatorcontrib>Wong, Germaine</creatorcontrib><creatorcontrib>Howard, Kirsten</creatorcontrib><creatorcontrib>Chapman, Jeremy R.</creatorcontrib><creatorcontrib>Castells, Antoni</creatorcontrib><creatorcontrib>Roger, Simon D.</creatorcontrib><creatorcontrib>Bourke, Michael J.</creatorcontrib><creatorcontrib>Macaskill, Petra</creatorcontrib><creatorcontrib>Turner, Robin</creatorcontrib><creatorcontrib>Lim, Wai H.</creatorcontrib><creatorcontrib>Lok, Charmaine E.</creatorcontrib><creatorcontrib>Diekmann, Fritz</creatorcontrib><creatorcontrib>Cross, Nicholas</creatorcontrib><creatorcontrib>Sen, Shaundeep</creatorcontrib><creatorcontrib>Allen, Richard D.</creatorcontrib><creatorcontrib>Chadban, Steven J.</creatorcontrib><creatorcontrib>Pollock, Carol A.</creatorcontrib><creatorcontrib>Tong, Allison</creatorcontrib><creatorcontrib>Teixeira-Pinto, Armando</creatorcontrib><creatorcontrib>Yang, Jean Y.</creatorcontrib><creatorcontrib>Kieu, Anh</creatorcontrib><creatorcontrib>James, Laura</creatorcontrib><creatorcontrib>Craig, Jonathan C.</creatorcontrib><title>Factors Associated With Advanced Colorectal Neoplasia in Patients With CKD</title><title>American journal of kidney diseases</title><addtitle>Am J Kidney Dis</addtitle><description>The risk of developing colorectal cancer in patients with chronic kidney disease (CKD) is twice that of the general population, but the factors associated with colorectal cancer are poorly understood. The aim of this study was to identify factors associated with advanced colorectal neoplasia in patients with CKD.
Prospective cohort study.
Patients with CKD stages 3-5, including those treated with maintenance dialysis or transplantation across 11 sites in Australia, New Zealand, Canada, and Spain, were screened for colorectal neoplasia using a fecal immunochemical test (FIT) as part of the Detecting Bowel Cancer in CKD (DETECT) Study.
Baseline characteristics for patients at the time of study enrollment were ascertained, including duration of CKD, comorbidities, and medications.
Advanced colorectal neoplasia was identified through a 2-step verification process with colonoscopy following positive FIT and 2-year clinical follow-up for all patients.
Potential factors associated with advanced colorectal neoplasia were explored using multivariable logistic regression. Sensitivity analyses were performed using grouped LASSO (least absolute shrinkage and selection operator) logistic regression.
Among 1,706 patients who received FIT-based screening—791 with CKD stages 3-5 not receiving kidney replacement therapy (KRT), 418 receiving dialysis, and 497 patients with a functioning kidney transplant—117 patients (6.9%) were detected to have advanced colorectal neoplasia (54 with CKD stages 3-5 without KRT, 34 receiving dialysis, and 29 transplant recipients), including 9 colorectal cancers. The factors found to be associated with advanced colorectal neoplasia included older age (OR per year older, 1.05 [95% CI, 1.03-1.07], P<0.001), male sex (OR, 2.27 [95% CI, 1.45-3.54], P<0.001), azathioprine use (OR, 2.99 [95% CI, 1.40-6.37], P=0.005), and erythropoiesis-stimulating agent use (OR, 1.92 [95% CI, 1.22-3.03], P=0.005). Grouped LASSO logistic regression revealed similar associations between these factors and advanced colorectal neoplasia.
Unmeasured confounding factors.
Older age, male sex, erythropoiesis-stimulating agents, and azathioprine were found to be significantly associated with advanced colorectal neoplasia in patients with CKD.</description><subject>Azathioprine</subject><subject>bowel cancer</subject><subject>chronic kidney disease (CKD)</subject><subject>Colonoscopy</subject><subject>colorectal cancer</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - epidemiology</subject><subject>dialysis</subject><subject>end-stage renal disease (ESRD)</subject><subject>epidemiology</subject><subject>fecal immunochemical test (FIT)</subject><subject>Feces</subject><subject>Humans</subject><subject>Male</subject><subject>Occult Blood</subject><subject>Prospective Studies</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><subject>Renal Insufficiency, Chronic - therapy</subject><subject>Risk Factors</subject><subject>transplant recipient</subject><issn>0272-6386</issn><issn>1523-6838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EouXxAyxQlmwS_GhsR2JTBcqrAhYglpZjO8IhjYudVuLvcZTCktVopHOvZg4AZwhmCObksslk86kzDDHKIMsgQntginJMUsoJ3wdTiBlOKeF0Ao5CaCCEBaH0EEzIbEYRonwKHhZS9c6HZB6CU1b2Rifvtv9I5norOxW30rXOG9XLNnkybt3KYGViu-RF9tZ0fRjx8vH6BBzUsg3mdDePwdvi5rW8S5fPt_flfJkqktM-VarWmDOOdMW1qXWudF5jhmSNlWa6lrzIqwpjJXPGDKVVgRRRVaVhwVE8mhyDi7F37d3XxoRerGxQpm1lZ9wmCJxTFtFoKKJ4RJV3IXhTi7W3K-m_BYJiIEQjBodicCggE9FhDJ3v-jfVyui_yK-0CFyNgIlfbq3xIqioIsqygyihnf2v_wf2OYKr</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Au, Eric H.</creator><creator>Wong, Germaine</creator><creator>Howard, Kirsten</creator><creator>Chapman, Jeremy R.</creator><creator>Castells, Antoni</creator><creator>Roger, Simon D.</creator><creator>Bourke, Michael J.</creator><creator>Macaskill, Petra</creator><creator>Turner, Robin</creator><creator>Lim, Wai H.</creator><creator>Lok, Charmaine E.</creator><creator>Diekmann, Fritz</creator><creator>Cross, Nicholas</creator><creator>Sen, Shaundeep</creator><creator>Allen, Richard D.</creator><creator>Chadban, Steven J.</creator><creator>Pollock, Carol A.</creator><creator>Tong, Allison</creator><creator>Teixeira-Pinto, Armando</creator><creator>Yang, Jean Y.</creator><creator>Kieu, Anh</creator><creator>James, Laura</creator><creator>Craig, Jonathan C.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6089-5913</orcidid></search><sort><creationdate>202204</creationdate><title>Factors Associated With Advanced Colorectal Neoplasia in Patients With CKD</title><author>Au, Eric H. ; Wong, Germaine ; Howard, Kirsten ; Chapman, Jeremy R. ; Castells, Antoni ; Roger, Simon D. ; Bourke, Michael J. ; Macaskill, Petra ; Turner, Robin ; Lim, Wai H. ; Lok, Charmaine E. ; Diekmann, Fritz ; Cross, Nicholas ; Sen, Shaundeep ; Allen, Richard D. ; Chadban, Steven J. ; Pollock, Carol A. ; Tong, Allison ; Teixeira-Pinto, Armando ; Yang, Jean Y. ; Kieu, Anh ; James, Laura ; Craig, Jonathan C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-ccfd28781db8defd5cd5f271af2cd7dfa895bb22ca577e66b91c3cbbd09811163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Azathioprine</topic><topic>bowel cancer</topic><topic>chronic kidney disease (CKD)</topic><topic>Colonoscopy</topic><topic>colorectal cancer</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Colorectal Neoplasms - epidemiology</topic><topic>dialysis</topic><topic>end-stage renal disease (ESRD)</topic><topic>epidemiology</topic><topic>fecal immunochemical test (FIT)</topic><topic>Feces</topic><topic>Humans</topic><topic>Male</topic><topic>Occult Blood</topic><topic>Prospective Studies</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Renal Insufficiency, Chronic - epidemiology</topic><topic>Renal Insufficiency, Chronic - therapy</topic><topic>Risk Factors</topic><topic>transplant recipient</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Au, Eric H.</creatorcontrib><creatorcontrib>Wong, Germaine</creatorcontrib><creatorcontrib>Howard, Kirsten</creatorcontrib><creatorcontrib>Chapman, Jeremy R.</creatorcontrib><creatorcontrib>Castells, Antoni</creatorcontrib><creatorcontrib>Roger, Simon D.</creatorcontrib><creatorcontrib>Bourke, Michael J.</creatorcontrib><creatorcontrib>Macaskill, Petra</creatorcontrib><creatorcontrib>Turner, Robin</creatorcontrib><creatorcontrib>Lim, Wai H.</creatorcontrib><creatorcontrib>Lok, Charmaine E.</creatorcontrib><creatorcontrib>Diekmann, Fritz</creatorcontrib><creatorcontrib>Cross, Nicholas</creatorcontrib><creatorcontrib>Sen, Shaundeep</creatorcontrib><creatorcontrib>Allen, Richard D.</creatorcontrib><creatorcontrib>Chadban, Steven J.</creatorcontrib><creatorcontrib>Pollock, Carol A.</creatorcontrib><creatorcontrib>Tong, Allison</creatorcontrib><creatorcontrib>Teixeira-Pinto, Armando</creatorcontrib><creatorcontrib>Yang, Jean Y.</creatorcontrib><creatorcontrib>Kieu, Anh</creatorcontrib><creatorcontrib>James, Laura</creatorcontrib><creatorcontrib>Craig, Jonathan C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of kidney diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Au, Eric H.</au><au>Wong, Germaine</au><au>Howard, Kirsten</au><au>Chapman, Jeremy R.</au><au>Castells, Antoni</au><au>Roger, Simon D.</au><au>Bourke, Michael J.</au><au>Macaskill, Petra</au><au>Turner, Robin</au><au>Lim, Wai H.</au><au>Lok, Charmaine E.</au><au>Diekmann, Fritz</au><au>Cross, Nicholas</au><au>Sen, Shaundeep</au><au>Allen, Richard D.</au><au>Chadban, Steven J.</au><au>Pollock, Carol A.</au><au>Tong, Allison</au><au>Teixeira-Pinto, Armando</au><au>Yang, Jean Y.</au><au>Kieu, Anh</au><au>James, Laura</au><au>Craig, Jonathan C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors Associated With Advanced Colorectal Neoplasia in Patients With CKD</atitle><jtitle>American journal of kidney diseases</jtitle><addtitle>Am J Kidney Dis</addtitle><date>2022-04</date><risdate>2022</risdate><volume>79</volume><issue>4</issue><spage>549</spage><epage>560</epage><pages>549-560</pages><issn>0272-6386</issn><eissn>1523-6838</eissn><abstract>The risk of developing colorectal cancer in patients with chronic kidney disease (CKD) is twice that of the general population, but the factors associated with colorectal cancer are poorly understood. The aim of this study was to identify factors associated with advanced colorectal neoplasia in patients with CKD.
Prospective cohort study.
Patients with CKD stages 3-5, including those treated with maintenance dialysis or transplantation across 11 sites in Australia, New Zealand, Canada, and Spain, were screened for colorectal neoplasia using a fecal immunochemical test (FIT) as part of the Detecting Bowel Cancer in CKD (DETECT) Study.
Baseline characteristics for patients at the time of study enrollment were ascertained, including duration of CKD, comorbidities, and medications.
Advanced colorectal neoplasia was identified through a 2-step verification process with colonoscopy following positive FIT and 2-year clinical follow-up for all patients.
Potential factors associated with advanced colorectal neoplasia were explored using multivariable logistic regression. Sensitivity analyses were performed using grouped LASSO (least absolute shrinkage and selection operator) logistic regression.
Among 1,706 patients who received FIT-based screening—791 with CKD stages 3-5 not receiving kidney replacement therapy (KRT), 418 receiving dialysis, and 497 patients with a functioning kidney transplant—117 patients (6.9%) were detected to have advanced colorectal neoplasia (54 with CKD stages 3-5 without KRT, 34 receiving dialysis, and 29 transplant recipients), including 9 colorectal cancers. The factors found to be associated with advanced colorectal neoplasia included older age (OR per year older, 1.05 [95% CI, 1.03-1.07], P<0.001), male sex (OR, 2.27 [95% CI, 1.45-3.54], P<0.001), azathioprine use (OR, 2.99 [95% CI, 1.40-6.37], P=0.005), and erythropoiesis-stimulating agent use (OR, 1.92 [95% CI, 1.22-3.03], P=0.005). Grouped LASSO logistic regression revealed similar associations between these factors and advanced colorectal neoplasia.
Unmeasured confounding factors.
Older age, male sex, erythropoiesis-stimulating agents, and azathioprine were found to be significantly associated with advanced colorectal neoplasia in patients with CKD.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34461168</pmid><doi>10.1053/j.ajkd.2021.07.011</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-6089-5913</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0272-6386 |
| ispartof | American journal of kidney diseases, 2022-04, Vol.79 (4), p.549-560 |
| issn | 0272-6386 1523-6838 |
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| subjects | Azathioprine bowel cancer chronic kidney disease (CKD) Colonoscopy colorectal cancer Colorectal Neoplasms - diagnosis Colorectal Neoplasms - epidemiology dialysis end-stage renal disease (ESRD) epidemiology fecal immunochemical test (FIT) Feces Humans Male Occult Blood Prospective Studies Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - epidemiology Renal Insufficiency, Chronic - therapy Risk Factors transplant recipient |
| title | Factors Associated With Advanced Colorectal Neoplasia in Patients With CKD |
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