Application of a simple unstructured kinetic and cost of goods models to support T‐cell therapy manufacture

Manufacturing of cell therapy products requires sufficient understanding of the cell culture variables and associated mechanisms for adequate control and risk analysis. The aim of this study was to apply an unstructured ordinary differential equation‐based model for prediction of T‐cell bioprocess o...

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Veröffentlicht in:	Biotechnology progress 2021-11, Vol.37 (6), p.e3205-n/a
Hauptverfasser:	Shariatzadeh, Maryam, Lopes, Adriana G., Glen, Katie E., Sinclair, Andrew, Thomas, Rob J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioreactors Cell Count Cell culture Cell Culture Techniques - methods Cell growth Cell Proliferation Cell therapy Cell- and Tissue-Based Therapy Cells, Cultured Consumption cost analysis Costs and Cost Analysis Differential equations Glucose Glucose metabolism Growth rate Humans Kinetics Manufacturing Manufacturing industry Minimum cost modeling framework Optimization process optimization Process parameters Risk analysis Risk management scalable T‐cell manufacturing T-Lymphocytes - cytology T‐cell processing
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