Thermosensitive Bioadhesive Hydrogels Based on Poly(N-isopropylacrilamide) and Poly(methyl vinyl ether-alt-maleic anhydride) for the Controlled Release of Metronidazole in the Vaginal Environment

The development of thermosensitive bioadhesive hydrogels as multifunctional platforms for the controlled delivery of microbicides is a valuable contribution for the in situ treatment of vagina infections. In this work, novel semi-interpenetrating network (s-IPN) hydrogels were prepared by the entrap...

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Veröffentlicht in:	Pharmaceutics 2021-08, Vol.13 (8), p.1284
Hauptverfasser:	Torres-Figueroa, Ana V., Pérez-Martínez, Cinthia J., Encinas, J. Carmelo, Burruel-Ibarra, Silvia, Silvas-García, María I., García Alegría, Alejandro M., del Castillo-Castro, Teresa
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adhesives bioadhesive hydrogel controlled drug release Fourier transforms Hydrogels metronidazole nanocomposite hydrogel Phase transitions Polymers Potassium Rheology Scanning electron microscopy Shear strain Sodium Spectrum analysis thermosensitive hydrogel Vagina
Online-Zugang:	Volltext
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