CARD14‐associated papulosquamous eruption (CAPE) in pediatric patients: Three additional cases and review of the literature
CARD14‐associated papulosquamous eruption (CAPE) is a proposed term that encompasses features ranging from psoriasis to pityriasis rubra pilaris (PRP) in association with CARD14 mutations. The early onset of the disease, prominent facial involvement, family history of an autosomal dominant trait, an...
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| Veröffentlicht in: | Pediatric dermatology 2021-09, Vol.38 (5), p.1237-1242 |
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| container_title | Pediatric dermatology |
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| creator | Frare, Cindy P. Blumstein, Alli J. Paller, Amy S. Pieretti, Lia Choate, Keith A. Bowcock, Anne M. Larralde, Margarita |
| description | CARD14‐associated papulosquamous eruption (CAPE) is a proposed term that encompasses features ranging from psoriasis to pityriasis rubra pilaris (PRP) in association with CARD14 mutations. The early onset of the disease, prominent facial involvement, family history of an autosomal dominant trait, and poor response to conventional treatment are characteristics of CAPE that distinguish it from classical psoriasis and PRP. We describe the clinical features, family history, and response to therapy in three unrelated children with CAPE and compare these characteristics with those of previously described pediatric patients. Testing for CARD14 mutations in children with early onset of features of psoriasis or pityriasis rubra pilaris and resistance to conventional therapy should be considered. |
| doi_str_mv | 10.1111/pde.14779 |
| format | Article |
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The early onset of the disease, prominent facial involvement, family history of an autosomal dominant trait, and poor response to conventional treatment are characteristics of CAPE that distinguish it from classical psoriasis and PRP. We describe the clinical features, family history, and response to therapy in three unrelated children with CAPE and compare these characteristics with those of previously described pediatric patients. 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Testing for CARD14 mutations in children with early onset of features of psoriasis or pityriasis rubra pilaris and resistance to conventional therapy should be considered.</description><subject>CARD Signaling Adaptor Proteins - genetics</subject><subject>CARD14</subject><subject>Case reports</subject><subject>Child</subject><subject>Children</subject><subject>Exanthema</subject><subject>Guanylate Cyclase</subject><subject>Humans</subject><subject>Literature reviews</subject><subject>Membrane Proteins</subject><subject>Monoclonal antibodies</subject><subject>Mutation</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Pityriasis</subject><subject>pityriasis rubra pilaris</subject><subject>Pityriasis Rubra Pilaris - diagnosis</subject><subject>Pityriasis Rubra Pilaris - drug therapy</subject><subject>Pityriasis Rubra Pilaris - genetics</subject><subject>Psoriasis</subject><subject>Skin eruptions</subject><subject>ustekinumab</subject><issn>0736-8046</issn><issn>1525-1470</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10d9qFDEUBvAgil1XL3wBCXjTXkybTDKZxIvCsl3_QMEi9TqcnTlxU2Yn02SmpReCj-Az-iRm3VpUMDch5MfHST5CXnJ2zPM6GVo85rKuzSMy41VZFfnAHpMZq4UqNJPqgDxL6YoxppXiT8mBkFLqUuoZ-bpcfDrj8se375BSaDyM2NIBhqkL6XqCbZgSxTgNow89PVwuLlZH1Pd0wDbT6JtsR4_9mN7Qy01EpNC2foehow0kTBT6lka88XhLg6PjBmnnR4wwThGfkycOuoQv7vc5-fx2dbl8X5x_fPdhuTgvGqmFKUDXa60Ec-iUqbVxHPhaYFlWApoaSwBXqvzYdcPROaVaaWRbonLGMSyNE3Nyus8dpvUW2yYPHKGzQ_RbiHc2gLd_3_R-Y7-EG6urWoucPCeH9wExXE-YRrv1qcGugx7zF9myUopJzoXK9PU_9CpMMf_HThlpal4zkdXRXjUxpBTRPQzDmd2VanOp9lep2b76c_oH-bvFDE724NZ3ePf_JHtxttpH_gT0C659</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Frare, Cindy P.</creator><creator>Blumstein, Alli J.</creator><creator>Paller, Amy S.</creator><creator>Pieretti, Lia</creator><creator>Choate, Keith A.</creator><creator>Bowcock, Anne M.</creator><creator>Larralde, Margarita</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3801-194X</orcidid><orcidid>https://orcid.org/0000-0001-6187-6549</orcidid><orcidid>https://orcid.org/0000-0001-8488-5675</orcidid></search><sort><creationdate>202109</creationdate><title>CARD14‐associated papulosquamous eruption (CAPE) in pediatric patients: Three additional cases and review of the literature</title><author>Frare, Cindy P. ; 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The early onset of the disease, prominent facial involvement, family history of an autosomal dominant trait, and poor response to conventional treatment are characteristics of CAPE that distinguish it from classical psoriasis and PRP. We describe the clinical features, family history, and response to therapy in three unrelated children with CAPE and compare these characteristics with those of previously described pediatric patients. Testing for CARD14 mutations in children with early onset of features of psoriasis or pityriasis rubra pilaris and resistance to conventional therapy should be considered.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34448248</pmid><doi>10.1111/pde.14779</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-3801-194X</orcidid><orcidid>https://orcid.org/0000-0001-6187-6549</orcidid><orcidid>https://orcid.org/0000-0001-8488-5675</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | CARD Signaling Adaptor Proteins - genetics CARD14 Case reports Child Children Exanthema Guanylate Cyclase Humans Literature reviews Membrane Proteins Monoclonal antibodies Mutation Patients Pediatrics Pityriasis pityriasis rubra pilaris Pityriasis Rubra Pilaris - diagnosis Pityriasis Rubra Pilaris - drug therapy Pityriasis Rubra Pilaris - genetics Psoriasis Skin eruptions ustekinumab |
| title | CARD14‐associated papulosquamous eruption (CAPE) in pediatric patients: Three additional cases and review of the literature |
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