Prognostic significance of tumor budding, poorly differentiated cluster, and desmoplastic reaction in endometrioid endometrial carcinomas
Aims The tumor budding (TB); poorly differentiated cluster (PDC); desmoplastic reaction (DR); and microcystic, elongated, and fragmented (MELF) patterns of invasion are pathological findings at the tumor invasion front associated with epithelial‐to‐mesenchymal transition. This study aimed to clarify...
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| Veröffentlicht in: | The journal of obstetrics and gynaecology research 2021-11, Vol.47 (11), p.3958-3967 |
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| container_issue | 11 |
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| container_title | The journal of obstetrics and gynaecology research |
| container_volume | 47 |
| creator | Yamamoto, Megumi Kaizaki, Yasuharu Kogami, Akiya Hara, Toshie Sakai, Yuya Tsuchida, Toru |
| description | Aims
The tumor budding (TB); poorly differentiated cluster (PDC); desmoplastic reaction (DR); and microcystic, elongated, and fragmented (MELF) patterns of invasion are pathological findings at the tumor invasion front associated with epithelial‐to‐mesenchymal transition. This study aimed to clarify the clinical significance of the TB, PDC, DR, and MELF patterns in endometrioid endometrial carcinomas (EEC).
Methods
Two hundred and eight cases of histologically proven EEC retrieved from the archives of the Department of Pathology, Fukui Prefectural Hospital, and diagnosed between January 2000 and August 2020 were retrospectively analyzed.
Results
The TB, PDC, DR, and MELF patterns were identified in 29 (13.9%), 47 (22.6%), 45 (21.6%), and 23 (11.1%) cases, respectively. Kaplan–Meier curve analysis with log‐rank test demonstrated that TB, PDC, and DR were associated with a lower progression‐free survival (p = 0.010, 0.002, and |
| doi_str_mv | 10.1111/jog.14997 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2566039995</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2590675314</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3547-e0651f4d74d2738629f84fd227be075698021a91d1078bcf7a8d87bdf276d05d3</originalsourceid><addsrcrecordid>eNp1kc9KAzEQxhdRsFYPvkHAi0K3TfZfNkcpWpVCPeh5ySaTJWU3WZNdpI_gW5u2giA4l5mB3zfMxxdF1wTPSajF1jZzkjFGT6IJyTIaY5oXp2FOMxKXmBbn0YX3W4wJZaScRF-vzjbG-kEL5HVjtNKCGwHIKjSMnXWoHqXUppmh3lrX7pDUSoEDM2g-gESiHf0Aboa4kUiC72zf8sM5B1wM2hqkDQIjbQeD01bL34W3SHAntLEd95fRmeKth6ufPo3eHx_elk_xerN6Xt6vY5HmwQ_gIicqkzSTCU3LImGqzJRMElrD3isrcUI4I5JgWtZCUV7KktZSJbSQOJfpNLo93u2d_RjBD1WnvYC25Qbs6KskLwqcMsbygN78Qbd2dCZ8FyiGC5qnJAvU3ZESznrvQFW90x13u4rgah9KUDXVIZTALo7sp25h9z9YvWxWR8U3f8CQpg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2590675314</pqid></control><display><type>article</type><title>Prognostic significance of tumor budding, poorly differentiated cluster, and desmoplastic reaction in endometrioid endometrial carcinomas</title><source>Wiley Online Library Journals【Remote access available】</source><creator>Yamamoto, Megumi ; Kaizaki, Yasuharu ; Kogami, Akiya ; Hara, Toshie ; Sakai, Yuya ; Tsuchida, Toru</creator><creatorcontrib>Yamamoto, Megumi ; Kaizaki, Yasuharu ; Kogami, Akiya ; Hara, Toshie ; Sakai, Yuya ; Tsuchida, Toru</creatorcontrib><description>Aims
The tumor budding (TB); poorly differentiated cluster (PDC); desmoplastic reaction (DR); and microcystic, elongated, and fragmented (MELF) patterns of invasion are pathological findings at the tumor invasion front associated with epithelial‐to‐mesenchymal transition. This study aimed to clarify the clinical significance of the TB, PDC, DR, and MELF patterns in endometrioid endometrial carcinomas (EEC).
Methods
Two hundred and eight cases of histologically proven EEC retrieved from the archives of the Department of Pathology, Fukui Prefectural Hospital, and diagnosed between January 2000 and August 2020 were retrospectively analyzed.
Results
The TB, PDC, DR, and MELF patterns were identified in 29 (13.9%), 47 (22.6%), 45 (21.6%), and 23 (11.1%) cases, respectively. Kaplan–Meier curve analysis with log‐rank test demonstrated that TB, PDC, and DR were associated with a lower progression‐free survival (p = 0.010, 0.002, and <0.0001, respectively), whereas the MELF pattern did not show any association (p = 0.668). In multivariate analyses, only DR was significantly associated with lower progression‐free survival (p = 0.034). Moreover, only PDC was associated with lower overall survival in univariate analysis (p = 0.018), but the association lost significance in multivariate analysis.
Conclusions
The present study revealed that the histological confirmation of TB, PDC, and DR at the tumor invasive front predicts poor prognosis in EEC. However, the MELF pattern was not a predictor of poor prognosis in EEC.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/jog.14997</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley & Sons Australia, Ltd</publisher><subject>Carcinoma ; Endometrial cancer ; endometrioid endometrial carcinomas ; Endometrium ; epithelial‐to‐mesenchymal transition ; Medical prognosis ; Mesenchyme ; Multivariate analysis ; pathological findings ; Prognosis ; prognostic factor ; Survival ; tumor invasive front ; Tumors ; Uterine cancer</subject><ispartof>The journal of obstetrics and gynaecology research, 2021-11, Vol.47 (11), p.3958-3967</ispartof><rights>2021 Japan Society of Obstetrics and Gynecology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3547-e0651f4d74d2738629f84fd227be075698021a91d1078bcf7a8d87bdf276d05d3</citedby><cites>FETCH-LOGICAL-c3547-e0651f4d74d2738629f84fd227be075698021a91d1078bcf7a8d87bdf276d05d3</cites><orcidid>0000-0002-6094-8894</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjog.14997$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjog.14997$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Yamamoto, Megumi</creatorcontrib><creatorcontrib>Kaizaki, Yasuharu</creatorcontrib><creatorcontrib>Kogami, Akiya</creatorcontrib><creatorcontrib>Hara, Toshie</creatorcontrib><creatorcontrib>Sakai, Yuya</creatorcontrib><creatorcontrib>Tsuchida, Toru</creatorcontrib><title>Prognostic significance of tumor budding, poorly differentiated cluster, and desmoplastic reaction in endometrioid endometrial carcinomas</title><title>The journal of obstetrics and gynaecology research</title><description>Aims
The tumor budding (TB); poorly differentiated cluster (PDC); desmoplastic reaction (DR); and microcystic, elongated, and fragmented (MELF) patterns of invasion are pathological findings at the tumor invasion front associated with epithelial‐to‐mesenchymal transition. This study aimed to clarify the clinical significance of the TB, PDC, DR, and MELF patterns in endometrioid endometrial carcinomas (EEC).
Methods
Two hundred and eight cases of histologically proven EEC retrieved from the archives of the Department of Pathology, Fukui Prefectural Hospital, and diagnosed between January 2000 and August 2020 were retrospectively analyzed.
Results
The TB, PDC, DR, and MELF patterns were identified in 29 (13.9%), 47 (22.6%), 45 (21.6%), and 23 (11.1%) cases, respectively. Kaplan–Meier curve analysis with log‐rank test demonstrated that TB, PDC, and DR were associated with a lower progression‐free survival (p = 0.010, 0.002, and <0.0001, respectively), whereas the MELF pattern did not show any association (p = 0.668). In multivariate analyses, only DR was significantly associated with lower progression‐free survival (p = 0.034). Moreover, only PDC was associated with lower overall survival in univariate analysis (p = 0.018), but the association lost significance in multivariate analysis.
Conclusions
The present study revealed that the histological confirmation of TB, PDC, and DR at the tumor invasive front predicts poor prognosis in EEC. However, the MELF pattern was not a predictor of poor prognosis in EEC.</description><subject>Carcinoma</subject><subject>Endometrial cancer</subject><subject>endometrioid endometrial carcinomas</subject><subject>Endometrium</subject><subject>epithelial‐to‐mesenchymal transition</subject><subject>Medical prognosis</subject><subject>Mesenchyme</subject><subject>Multivariate analysis</subject><subject>pathological findings</subject><subject>Prognosis</subject><subject>prognostic factor</subject><subject>Survival</subject><subject>tumor invasive front</subject><subject>Tumors</subject><subject>Uterine cancer</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kc9KAzEQxhdRsFYPvkHAi0K3TfZfNkcpWpVCPeh5ySaTJWU3WZNdpI_gW5u2giA4l5mB3zfMxxdF1wTPSajF1jZzkjFGT6IJyTIaY5oXp2FOMxKXmBbn0YX3W4wJZaScRF-vzjbG-kEL5HVjtNKCGwHIKjSMnXWoHqXUppmh3lrX7pDUSoEDM2g-gESiHf0Aboa4kUiC72zf8sM5B1wM2hqkDQIjbQeD01bL34W3SHAntLEd95fRmeKth6ufPo3eHx_elk_xerN6Xt6vY5HmwQ_gIicqkzSTCU3LImGqzJRMElrD3isrcUI4I5JgWtZCUV7KktZSJbSQOJfpNLo93u2d_RjBD1WnvYC25Qbs6KskLwqcMsbygN78Qbd2dCZ8FyiGC5qnJAvU3ZESznrvQFW90x13u4rgah9KUDXVIZTALo7sp25h9z9YvWxWR8U3f8CQpg</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Yamamoto, Megumi</creator><creator>Kaizaki, Yasuharu</creator><creator>Kogami, Akiya</creator><creator>Hara, Toshie</creator><creator>Sakai, Yuya</creator><creator>Tsuchida, Toru</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6094-8894</orcidid></search><sort><creationdate>202111</creationdate><title>Prognostic significance of tumor budding, poorly differentiated cluster, and desmoplastic reaction in endometrioid endometrial carcinomas</title><author>Yamamoto, Megumi ; Kaizaki, Yasuharu ; Kogami, Akiya ; Hara, Toshie ; Sakai, Yuya ; Tsuchida, Toru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3547-e0651f4d74d2738629f84fd227be075698021a91d1078bcf7a8d87bdf276d05d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Carcinoma</topic><topic>Endometrial cancer</topic><topic>endometrioid endometrial carcinomas</topic><topic>Endometrium</topic><topic>epithelial‐to‐mesenchymal transition</topic><topic>Medical prognosis</topic><topic>Mesenchyme</topic><topic>Multivariate analysis</topic><topic>pathological findings</topic><topic>Prognosis</topic><topic>prognostic factor</topic><topic>Survival</topic><topic>tumor invasive front</topic><topic>Tumors</topic><topic>Uterine cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamamoto, Megumi</creatorcontrib><creatorcontrib>Kaizaki, Yasuharu</creatorcontrib><creatorcontrib>Kogami, Akiya</creatorcontrib><creatorcontrib>Hara, Toshie</creatorcontrib><creatorcontrib>Sakai, Yuya</creatorcontrib><creatorcontrib>Tsuchida, Toru</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamamoto, Megumi</au><au>Kaizaki, Yasuharu</au><au>Kogami, Akiya</au><au>Hara, Toshie</au><au>Sakai, Yuya</au><au>Tsuchida, Toru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of tumor budding, poorly differentiated cluster, and desmoplastic reaction in endometrioid endometrial carcinomas</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><date>2021-11</date><risdate>2021</risdate><volume>47</volume><issue>11</issue><spage>3958</spage><epage>3967</epage><pages>3958-3967</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Aims
The tumor budding (TB); poorly differentiated cluster (PDC); desmoplastic reaction (DR); and microcystic, elongated, and fragmented (MELF) patterns of invasion are pathological findings at the tumor invasion front associated with epithelial‐to‐mesenchymal transition. This study aimed to clarify the clinical significance of the TB, PDC, DR, and MELF patterns in endometrioid endometrial carcinomas (EEC).
Methods
Two hundred and eight cases of histologically proven EEC retrieved from the archives of the Department of Pathology, Fukui Prefectural Hospital, and diagnosed between January 2000 and August 2020 were retrospectively analyzed.
Results
The TB, PDC, DR, and MELF patterns were identified in 29 (13.9%), 47 (22.6%), 45 (21.6%), and 23 (11.1%) cases, respectively. Kaplan–Meier curve analysis with log‐rank test demonstrated that TB, PDC, and DR were associated with a lower progression‐free survival (p = 0.010, 0.002, and <0.0001, respectively), whereas the MELF pattern did not show any association (p = 0.668). In multivariate analyses, only DR was significantly associated with lower progression‐free survival (p = 0.034). Moreover, only PDC was associated with lower overall survival in univariate analysis (p = 0.018), but the association lost significance in multivariate analysis.
Conclusions
The present study revealed that the histological confirmation of TB, PDC, and DR at the tumor invasive front predicts poor prognosis in EEC. However, the MELF pattern was not a predictor of poor prognosis in EEC.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley & Sons Australia, Ltd</pub><doi>10.1111/jog.14997</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-6094-8894</orcidid></addata></record> |
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| subjects | Carcinoma Endometrial cancer endometrioid endometrial carcinomas Endometrium epithelial‐to‐mesenchymal transition Medical prognosis Mesenchyme Multivariate analysis pathological findings Prognosis prognostic factor Survival tumor invasive front Tumors Uterine cancer |
| title | Prognostic significance of tumor budding, poorly differentiated cluster, and desmoplastic reaction in endometrioid endometrial carcinomas |
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