The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta‐analysis
A systematic review and a meta‐analytic approach were considered to investigate the effects of lemon balm as a medicinal herb on anxiety and depression in clinical trials and its side effects. All randomized clinical trials published up to October 30, 2020 that examined lemon balm in patients with s...
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| Veröffentlicht in: | Phytotherapy research 2021-12, Vol.35 (12), p.6690-6705 |
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| creator | Ghazizadeh, Javid Sadigh‐Eteghad, Saeed Marx, Wolfgang Fakhari, Ali Hamedeyazdan, Sanaz Torbati, Mohammadali Taheri‐Tarighi, Somaiyeh Araj‐khodaei, Mostafa Mirghafourvand, Mojgan |
| description | A systematic review and a meta‐analytic approach were considered to investigate the effects of lemon balm as a medicinal herb on anxiety and depression in clinical trials and its side effects. All randomized clinical trials published up to October 30, 2020 that examined lemon balm in patients with symptoms of depression or anxiety, with acute or chronic manifestations, were searched in 12 online databases. Statistical analysis was performed using RevMan software. Continuous data were analyzed using standardized mean differences. Statistical heterogeneity was assessed using Chi2, I2, and p value tests. Based on meta‐analysis results, lemon balm significantly improved mean anxiety and depression scores compared with the placebo (SMD: ‐0.98; 95% CI: −1.63 to −0.33; p = 0.003), (SMD: ‐0.47; 95% CI: −0.73 to −0.21; p = 0.0005) respectively, without serious side effects. Current evidence suggests that lemon balm may be effective in improving anxiety and depressive symptoms, particularly in the acute setting. Due to the high level of heterogeneity between studies, results should be interpreted with caution. The small number of clinical trials and differences between their methods were the limitations of the present study. Further high‐quality studies are needed to firmly establish the clinical efficacy of the lemon balm. |
| doi_str_mv | 10.1002/ptr.7252 |
| format | Article |
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All randomized clinical trials published up to October 30, 2020 that examined lemon balm in patients with symptoms of depression or anxiety, with acute or chronic manifestations, were searched in 12 online databases. Statistical analysis was performed using RevMan software. Continuous data were analyzed using standardized mean differences. Statistical heterogeneity was assessed using Chi2, I2, and p value tests. Based on meta‐analysis results, lemon balm significantly improved mean anxiety and depression scores compared with the placebo (SMD: ‐0.98; 95% CI: −1.63 to −0.33; p = 0.003), (SMD: ‐0.47; 95% CI: −0.73 to −0.21; p = 0.0005) respectively, without serious side effects. Current evidence suggests that lemon balm may be effective in improving anxiety and depressive symptoms, particularly in the acute setting. Due to the high level of heterogeneity between studies, results should be interpreted with caution. The small number of clinical trials and differences between their methods were the limitations of the present study. Further high‐quality studies are needed to firmly establish the clinical efficacy of the lemon balm.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.7252</identifier><identifier>PMID: 34449930</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Anxiety ; Anxiety - drug therapy ; Anxiety Disorders - drug therapy ; Clinical trials ; depression ; Depression - drug therapy ; Fruits ; Herbal medicine ; Heterogeneity ; Humans ; lemon balm ; Medicinal plants ; Melissa ; Melissa officinalis ; Mental depression ; Meta-analysis ; Plant Extracts - pharmacology ; Plants, Medicinal ; Side effects ; Statistical analysis ; Statistics ; Systematic review</subject><ispartof>Phytotherapy research, 2021-12, Vol.35 (12), p.6690-6705</ispartof><rights>2021 John Wiley & Sons Ltd.</rights><rights>2021 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3492-4fa5b9ce5a51e137473b972715d42ac7bc9707621ad393cdee38ac9d1fed73ed3</citedby><cites>FETCH-LOGICAL-c3492-4fa5b9ce5a51e137473b972715d42ac7bc9707621ad393cdee38ac9d1fed73ed3</cites><orcidid>0000-0002-8556-8230 ; 0000-0001-5040-9769 ; 0000-0002-2590-8467 ; 0000-0001-8360-4309 ; 0000-0003-2872-1072 ; 0000-0002-3731-7146 ; 0000-0002-8327-4925 ; 0000-0002-8950-9879</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.7252$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.7252$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34449930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghazizadeh, Javid</creatorcontrib><creatorcontrib>Sadigh‐Eteghad, Saeed</creatorcontrib><creatorcontrib>Marx, Wolfgang</creatorcontrib><creatorcontrib>Fakhari, Ali</creatorcontrib><creatorcontrib>Hamedeyazdan, Sanaz</creatorcontrib><creatorcontrib>Torbati, Mohammadali</creatorcontrib><creatorcontrib>Taheri‐Tarighi, Somaiyeh</creatorcontrib><creatorcontrib>Araj‐khodaei, Mostafa</creatorcontrib><creatorcontrib>Mirghafourvand, Mojgan</creatorcontrib><title>The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta‐analysis</title><title>Phytotherapy research</title><addtitle>Phytother Res</addtitle><description>A systematic review and a meta‐analytic approach were considered to investigate the effects of lemon balm as a medicinal herb on anxiety and depression in clinical trials and its side effects. All randomized clinical trials published up to October 30, 2020 that examined lemon balm in patients with symptoms of depression or anxiety, with acute or chronic manifestations, were searched in 12 online databases. Statistical analysis was performed using RevMan software. Continuous data were analyzed using standardized mean differences. Statistical heterogeneity was assessed using Chi2, I2, and p value tests. Based on meta‐analysis results, lemon balm significantly improved mean anxiety and depression scores compared with the placebo (SMD: ‐0.98; 95% CI: −1.63 to −0.33; p = 0.003), (SMD: ‐0.47; 95% CI: −0.73 to −0.21; p = 0.0005) respectively, without serious side effects. Current evidence suggests that lemon balm may be effective in improving anxiety and depressive symptoms, particularly in the acute setting. Due to the high level of heterogeneity between studies, results should be interpreted with caution. The small number of clinical trials and differences between their methods were the limitations of the present study. Further high‐quality studies are needed to firmly establish the clinical efficacy of the lemon balm.</description><subject>Anxiety</subject><subject>Anxiety - drug therapy</subject><subject>Anxiety Disorders - drug therapy</subject><subject>Clinical trials</subject><subject>depression</subject><subject>Depression - drug therapy</subject><subject>Fruits</subject><subject>Herbal medicine</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>lemon balm</subject><subject>Medicinal plants</subject><subject>Melissa</subject><subject>Melissa officinalis</subject><subject>Mental depression</subject><subject>Meta-analysis</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal</subject><subject>Side effects</subject><subject>Statistical analysis</subject><subject>Statistics</subject><subject>Systematic review</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc-KFDEQh4O4uOMo-ARLwMt46DH_ejLZ2zLsqjCLIiN4a9JJNWZId4-pHte-efToM_okZndmXRA8hEoVX30U_Ah5wdmcMyZe74Y016IUj8iEM2MKXmr5mEyYKXmh-PLzKXmKuGWMGcHUE3IqlVLGSDYhPzdfgELTgBuQ9g2N0PYdrW1s6ewaYkC0edwEFzqbO7qev6IZ8LBLgBjy13Y-v-8BhpGGjroYuuBspEMKNuI5vaA44gCtHYKjCb4FuLnbaWGwv3_8stk7YsBn5KTJPDw_1in5dHW5Wb0t1u_fvFtdrAsnlRGFamxZGwelLTlwqZWWtdFC89IrYZ2undFMLwS3XhrpPIBcWmc8b8BrCV5Oyezg3aX-6x5wqNqADmK0HfR7rES5WDBpmJYZffkPuu33Kd-bqQUXSiyZWD4IXeoREzTVLoXWprHirLpNp8rpVLfpZPTsKNzXLfi_4H0cGSgOwE2IMP5XVH3YfLwT_gHBjJqS</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Ghazizadeh, Javid</creator><creator>Sadigh‐Eteghad, Saeed</creator><creator>Marx, Wolfgang</creator><creator>Fakhari, Ali</creator><creator>Hamedeyazdan, Sanaz</creator><creator>Torbati, Mohammadali</creator><creator>Taheri‐Tarighi, Somaiyeh</creator><creator>Araj‐khodaei, Mostafa</creator><creator>Mirghafourvand, Mojgan</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8556-8230</orcidid><orcidid>https://orcid.org/0000-0001-5040-9769</orcidid><orcidid>https://orcid.org/0000-0002-2590-8467</orcidid><orcidid>https://orcid.org/0000-0001-8360-4309</orcidid><orcidid>https://orcid.org/0000-0003-2872-1072</orcidid><orcidid>https://orcid.org/0000-0002-3731-7146</orcidid><orcidid>https://orcid.org/0000-0002-8327-4925</orcidid><orcidid>https://orcid.org/0000-0002-8950-9879</orcidid></search><sort><creationdate>202112</creationdate><title>The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta‐analysis</title><author>Ghazizadeh, Javid ; 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All randomized clinical trials published up to October 30, 2020 that examined lemon balm in patients with symptoms of depression or anxiety, with acute or chronic manifestations, were searched in 12 online databases. Statistical analysis was performed using RevMan software. Continuous data were analyzed using standardized mean differences. Statistical heterogeneity was assessed using Chi2, I2, and p value tests. Based on meta‐analysis results, lemon balm significantly improved mean anxiety and depression scores compared with the placebo (SMD: ‐0.98; 95% CI: −1.63 to −0.33; p = 0.003), (SMD: ‐0.47; 95% CI: −0.73 to −0.21; p = 0.0005) respectively, without serious side effects. Current evidence suggests that lemon balm may be effective in improving anxiety and depressive symptoms, particularly in the acute setting. Due to the high level of heterogeneity between studies, results should be interpreted with caution. The small number of clinical trials and differences between their methods were the limitations of the present study. Further high‐quality studies are needed to firmly establish the clinical efficacy of the lemon balm.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>34449930</pmid><doi>10.1002/ptr.7252</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-8556-8230</orcidid><orcidid>https://orcid.org/0000-0001-5040-9769</orcidid><orcidid>https://orcid.org/0000-0002-2590-8467</orcidid><orcidid>https://orcid.org/0000-0001-8360-4309</orcidid><orcidid>https://orcid.org/0000-0003-2872-1072</orcidid><orcidid>https://orcid.org/0000-0002-3731-7146</orcidid><orcidid>https://orcid.org/0000-0002-8327-4925</orcidid><orcidid>https://orcid.org/0000-0002-8950-9879</orcidid></addata></record> |
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| subjects | Anxiety Anxiety - drug therapy Anxiety Disorders - drug therapy Clinical trials depression Depression - drug therapy Fruits Herbal medicine Heterogeneity Humans lemon balm Medicinal plants Melissa Melissa officinalis Mental depression Meta-analysis Plant Extracts - pharmacology Plants, Medicinal Side effects Statistical analysis Statistics Systematic review |
| title | The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta‐analysis |
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