Inhibition of Aβ peptide aggregation by ruthenium(II) polypyridyl complexes through copper chelation

Alzheimer's disease (AD) is known as a complex multifactorial syndrome and both metal chelators and amyloid β peptide (Aβ) inhibitors show promise against AD. Herein, four small hybrid compounds have been designed and synthesized utilizing 8-hydroxyquinoline, pyridine or imidazole as chelators...

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Veröffentlicht in:	Journal of inorganic biochemistry 2021-11, Vol.224, p.111591-111591, Article 111591
Hauptverfasser:	Peng, Yan-Bo, Tao, Can, Tan, Cai-Ping, Zhao, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - metabolism Aβ peptides Benzimidazoles - pharmacology Cell Line, Tumor Cell Survival - drug effects Chelating Agents - chemistry Chelating Agents - pharmacology Coordination Complexes - chemistry Copper - chemistry Cu2+ chelating Humans Mitochondria - metabolism Neurons - metabolism Oxyquinoline - pharmacology Protein Aggregates Protein Aggregation, Pathological - metabolism Reactive Oxygen Species - metabolism Ruthenium - chemistry Ruthenium - pharmacology Ruthenium complexes
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