Estrone–salicylaldehyde N-methylated thiosemicarbazone hybrids and their copper complexes: solution structure, stability and anticancer activity in tumour spheroids

The terminal N- mono- and dimethylated derivatives of an estrone–salicylaldehyde thiosemicarbazone hybrid and their highly cytotoxic Cu(II) complexes were synthesized and characterized in addition to their structurally related simpler bicyclic analogues. Solution stability and structure of the compl...

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Veröffentlicht in:	Journal of biological inorganic chemistry 2021-10, Vol.26 (7), p.775-791
Hauptverfasser:	Petrasheuskaya, Tatsiana V., Wernitznig, Debora, Kiss, Márton A., May, Nóra V., Wenisch, Dominik, Keppler, Bernhard K., Frank, Éva, Enyedy, Éva A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Antineoplastic Agents - pharmacology Antitumor activity Apoptosis Biochemistry Biomedical and Life Sciences Cancer Caspase-3 Caspase-7 Cell death Coordination Complexes - pharmacology Copper Crystallography, X-Ray Cytotoxicity Dimethyl sulfoxide Electron spin resonance Estrone Humans Hybrids Inorganic chemistry Life Sciences Ligands Methylation Microbiology Neoplasms Original Paper pH effects Speciation Spectrophotometry Spectroscopy Spheroids Thiosemicarbazones - pharmacology Tumors
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