Curcumol Alleviates the Inflammation of Nucleus Pulposus Cells via the PI3K/Akt/NF-κB Signaling Pathway and Delays Intervertebral Disk Degeneration

Intervertebral disk degeneration (IVDD) is closely associated with inflammatory environments. Curcumol has been shown to alleviate inflammation in various disease models, but its effects on IVDD remain unclear. In this study, we sought to determine the mechanism of curcumol in tumor necrosis factor...

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Veröffentlicht in:	World neurosurgery 2021-11, Vol.155, p.e402-e411
Hauptverfasser:	He, Shenghua, Fu, Yuanfei, Yan, Bona, Tan, Huangsheng, Li, Haokang, Li, Jin, Huang, Dan, Huang, Zhuohan, Lai, Juyi, Feng, Hualong, Sun, Zhitao, Lan, Zhiming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cell Survival - drug effects Cell Survival - physiology Curcumol Dose-Response Relationship, Drug Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Inflammation Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Intervertebral Disc Degeneration - metabolism Intervertebral Disc Degeneration - pathology Intervertebral Disc Degeneration - prevention & control Intervertebral disk degeneration Male Mice Mice, Inbred C57BL NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism Nucleus Pulposus - drug effects Nucleus Pulposus - metabolism Nucleus Pulposus - pathology Nucleus pulposus cells Phosphatidylinositol 3-Kinases - metabolism Phosphoinositide-3 Kinase Inhibitors - pharmacology Phosphoinositide-3 Kinase Inhibitors - therapeutic use PI3K/Akt/NF-κB Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Rats Sesquiterpenes - pharmacology Sesquiterpenes - therapeutic use Signal Transduction - drug effects Signal Transduction - physiology
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