Pathophysiology, diagnosis and management of cardiac toxicity induced by immune checkpoint inhibitors and BRAF and MEK inhibitors

•Cardiotoxicity, in particular myocarditis, induced by ICI is rare (1%) but potentially lethal.•BRAFi/MEKi inhibitors may induce reduction in left ventricular ejection fraction (5–11%), hypertension (11–30%) or QT interval prolongation (0–5%)•Shared epitopes between melanoma cells and cardiac tissue...

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Veröffentlicht in:	Cancer treatment reviews 2021-11, Vol.100, p.102282-102282, Article 102282
Hauptverfasser:	Arangalage, Dimitri, Degrauwe, Nils, Michielin, Olivier, Monney, Pierre, Özdemir, Berna C.
Format:	Artikel
Sprache:	eng
Schlagworte:	BRAF inhibitor Cardiotoxicity Heart failure Hypertension Immune checkpoint inhibitors Immune related adverse events MEK inhibitor Melanoma Myocarditis Pathophysiology
Online-Zugang:	Volltext
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