Preliminary Animal Study on Bone Formation Ability of Commercialized Particle-Type Bone Graft with Increased Operability by Hydrogel
The purpose of this study was to evaluate the bone-generating ability of a new bovine-derived xenograft (S1-XB) containing hydrogel. For control purposes, we used Bio-Oss and Bone-XB bovine-derived xenografts. S1-XB was produced by mixing Bone-XB and hydrogel. Cell proliferation and differentiation...
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| description | The purpose of this study was to evaluate the bone-generating ability of a new bovine-derived xenograft (S1-XB) containing hydrogel. For control purposes, we used Bio-Oss and Bone-XB bovine-derived xenografts. S1-XB was produced by mixing Bone-XB and hydrogel. Cell proliferation and differentiation studies were performed to assess cytotoxicities and cell responses. For in vivo study, 8 mm-sized cranial defects were formed in 16 rats, and then the bone substitutes were transplanted into defect sites in the four study groups, that is, a Bio-Oss group, a Bone-XB group, an S1-XB group, and a control (all n = 4); in the control group defects were left empty. Eight weeks after surgery, new bone formation areas were measured histomorphometrically. In the cell study, extracts of Bio-Oss, Bone-XB, and S1-XB showed good results in terms of the osteogenic differentiation of human mesenchymal stem cells (hMSCs) and no cytotoxic reaction was evident. No significant difference was observed between mean new bone areas in the Bio-Oss (36.93 +/- 4.27%), Bone-XB (35.07 +/- 3.23%), and S1-XB (30.80 +/- 6.41%) groups, but new bone area was significantly smaller in the control group (18.73 +/- 5.59%) (p < 0.05). Bovine-derived bone graft material containing hydrogel (S1-XB) had a better cellular response and an osteogenic effect similar to Bio-Oss. |
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For control purposes, we used Bio-Oss and Bone-XB bovine-derived xenografts. S1-XB was produced by mixing Bone-XB and hydrogel. Cell proliferation and differentiation studies were performed to assess cytotoxicities and cell responses. For in vivo study, 8 mm-sized cranial defects were formed in 16 rats, and then the bone substitutes were transplanted into defect sites in the four study groups, that is, a Bio-Oss group, a Bone-XB group, an S1-XB group, and a control (all n = 4); in the control group defects were left empty. Eight weeks after surgery, new bone formation areas were measured histomorphometrically. In the cell study, extracts of Bio-Oss, Bone-XB, and S1-XB showed good results in terms of the osteogenic differentiation of human mesenchymal stem cells (hMSCs) and no cytotoxic reaction was evident. No significant difference was observed between mean new bone areas in the Bio-Oss (36.93 +/- 4.27%), Bone-XB (35.07 +/- 3.23%), and S1-XB (30.80 +/- 6.41%) groups, but new bone area was significantly smaller in the control group (18.73 +/- 5.59%) (p < 0.05). Bovine-derived bone graft material containing hydrogel (S1-XB) had a better cellular response and an osteogenic effect similar to Bio-Oss.</description><identifier>ISSN: 1996-1944</identifier><identifier>EISSN: 1996-1944</identifier><identifier>DOI: 10.3390/ma14164464</identifier><identifier>PMID: 34442986</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject>Animals ; Biocompatibility ; Biomedical materials ; Cattle ; Chemistry ; Chemistry, Physical ; Commercialization ; Defects ; Differentiation (biology) ; Experiments ; Grafting ; Grafts ; Hydrogels ; In vivo methods and tests ; Materials Science ; Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering ; Phosphatase ; Physical Sciences ; Physics ; Physics, Applied ; Physics, Condensed Matter ; Scanning electron microscopy ; Science & Technology ; Skin & tissue grafts ; Stem cells ; Substitute bone ; Surgery ; Technology ; Xenotransplantation</subject><ispartof>Materials, 2021-08, Vol.14 (16), p.4464, Article 4464</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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No significant difference was observed between mean new bone areas in the Bio-Oss (36.93 +/- 4.27%), Bone-XB (35.07 +/- 3.23%), and S1-XB (30.80 +/- 6.41%) groups, but new bone area was significantly smaller in the control group (18.73 +/- 5.59%) (p < 0.05). Bovine-derived bone graft material containing hydrogel (S1-XB) had a better cellular response and an osteogenic effect similar to Bio-Oss.</abstract><cop>BASEL</cop><pub>Mdpi</pub><pmid>34442986</pmid><doi>10.3390/ma14164464</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-2962-9553</orcidid><orcidid>https://orcid.org/0000-0002-9361-732X</orcidid><orcidid>https://orcid.org/0000-0003-2174-7333</orcidid><orcidid>https://orcid.org/0000-0001-6714-8315</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biocompatibility Biomedical materials Cattle Chemistry Chemistry, Physical Commercialization Defects Differentiation (biology) Experiments Grafting Grafts Hydrogels In vivo methods and tests Materials Science Materials Science, Multidisciplinary Metallurgy & Metallurgical Engineering Phosphatase Physical Sciences Physics Physics, Applied Physics, Condensed Matter Scanning electron microscopy Science & Technology Skin & tissue grafts Stem cells Substitute bone Surgery Technology Xenotransplantation |
| title | Preliminary Animal Study on Bone Formation Ability of Commercialized Particle-Type Bone Graft with Increased Operability by Hydrogel |
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