Development and Validation of StrataNGS, a Multiplex PCR, Semiconductor Sequencing-Based Comprehensive Genomic Profiling Test

Despite widespread use in targeted tumor testing, multiplex PCR/semiconductor (Ion Torrent) sequencing-based assessment of all comprehensive genomic profiling (CGP) variant classes has been limited. Herein, we describe the development and validation of StrataNGS, a 429-gene, multiplex PCR/semiconduc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of molecular diagnostics : JMD 2021-11, Vol.23 (11), p.1515-1533
Hauptverfasser:	Tomlins, Scott A., Hovelson, Daniel H., Harms, Paul, Drewery, Stephanie, Falkner, Jayson, Fischer, Andrew, Hipp, Jennifer, Kwiatkowski, Kat, Lazo de la Vega, Lorena, Mitchell, Khalis, Reeder, Travis, Siddiqui, Javed, Vakil, Hana, Johnson, D. Bryan, Rhodes, Daniel R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - genetics Data Accuracy DNA Copy Number Variations Exome Feasibility Studies Gene Fusion Genome, Human Genomics - methods High-Throughput Nucleotide Sequencing - methods Humans Limit of Detection Microsatellite Instability Multiplex Polymerase Chain Reaction - methods Neoplasms - genetics Neoplasms - pathology Reproducibility of Results Sequence Analysis, DNA - methods Sequence Analysis, RNA - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!