Functional and structural properties of human patellar articular cartilage in osteoarthritis
Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known. Further, the patellofemoral joint loading is thought to include more sliding and shear compared to other knee joint locations, thus...
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| Veröffentlicht in: | Journal of biomechanics 2021-09, Vol.126, p.110634-110634, Article 110634 |
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| creator | Nissinen, Mikko T. Hänninen, Nina Prakash, Mithilesh Mäkelä, Janne T.A. Nissi, Mikko J. Töyräs, Juha Nieminen, Miika T. Korhonen, Rami K. Tanska, Petri |
| description | Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known. Further, the patellofemoral joint loading is thought to include more sliding and shear compared to other knee joint locations, thus, the relations between structural and functional changes may differ in OA. Thus, our aim was to determine the patellar cartilage FRPE properties followed by associating them with the structure and composition. Osteochondral plugs (n = 14) were harvested from the patellae of six cadavers. Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples. The initial fibril network modulus and permeability strain-dependency factor were 72% and 63% smaller in advanced OA samples when compared to early OA samples. Further, we observed a negative association between the initial fibril network modulus and optical retardation (r = -0.537, p |
| doi_str_mv | 10.1016/j.jbiomech.2021.110634 |
| format | Article |
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Further, the patellofemoral joint loading is thought to include more sliding and shear compared to other knee joint locations, thus, the relations between structural and functional changes may differ in OA. Thus, our aim was to determine the patellar cartilage FRPE properties followed by associating them with the structure and composition. Osteochondral plugs (n = 14) were harvested from the patellae of six cadavers. Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples. The initial fibril network modulus and permeability strain-dependency factor were 72% and 63% smaller in advanced OA samples when compared to early OA samples. Further, we observed a negative association between the initial fibril network modulus and optical retardation (r = -0.537, p < 0.05). We also observed positive associations between 1) the initial permeability and optical retardation (r = 0.547, p < 0.05), and 2) the initial fibril network modulus and optical density (r = 0.670, p < 0.01).These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA. The characterization of these changes is important to improve the representativeness of knee joint models in tissue and cell scale.</description><identifier>ISSN: 0021-9290</identifier><identifier>EISSN: 1873-2380</identifier><identifier>DOI: 10.1016/j.jbiomech.2021.110634</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Arthritis ; Biomedical materials ; Cadavers ; Cartilage ; Cartilage (articular) ; Cartilage diseases ; Cell culture ; Collagen ; Fibril-reinforced poroelastic ; Fibrils ; Finite element analysis ; Joints (anatomy) ; Knee ; Material properties ; Mechanical testing ; Microscopy ; Optical density ; Optical properties ; Osteoarthritis ; Permeability ; Plugs ; Proteoglycan ; Proteoglycans ; Structure-function relationships</subject><ispartof>Journal of biomechanics, 2021-09, Vol.126, p.110634-110634, Article 110634</ispartof><rights>2021 The Authors</rights><rights>2021. The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-4c3a41e1c6db209a114b945e2b55804d47abf1e87093e12a7720ba6dd6d7b97e3</citedby><cites>FETCH-LOGICAL-c421t-4c3a41e1c6db209a114b945e2b55804d47abf1e87093e12a7720ba6dd6d7b97e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S002192902100405X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Nissinen, Mikko T.</creatorcontrib><creatorcontrib>Hänninen, Nina</creatorcontrib><creatorcontrib>Prakash, Mithilesh</creatorcontrib><creatorcontrib>Mäkelä, Janne T.A.</creatorcontrib><creatorcontrib>Nissi, Mikko J.</creatorcontrib><creatorcontrib>Töyräs, Juha</creatorcontrib><creatorcontrib>Nieminen, Miika T.</creatorcontrib><creatorcontrib>Korhonen, Rami K.</creatorcontrib><creatorcontrib>Tanska, Petri</creatorcontrib><title>Functional and structural properties of human patellar articular cartilage in osteoarthritis</title><title>Journal of biomechanics</title><description>Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known. Further, the patellofemoral joint loading is thought to include more sliding and shear compared to other knee joint locations, thus, the relations between structural and functional changes may differ in OA. Thus, our aim was to determine the patellar cartilage FRPE properties followed by associating them with the structure and composition. Osteochondral plugs (n = 14) were harvested from the patellae of six cadavers. Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples. The initial fibril network modulus and permeability strain-dependency factor were 72% and 63% smaller in advanced OA samples when compared to early OA samples. Further, we observed a negative association between the initial fibril network modulus and optical retardation (r = -0.537, p < 0.05). We also observed positive associations between 1) the initial permeability and optical retardation (r = 0.547, p < 0.05), and 2) the initial fibril network modulus and optical density (r = 0.670, p < 0.01).These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA. The characterization of these changes is important to improve the representativeness of knee joint models in tissue and cell scale.</description><subject>Arthritis</subject><subject>Biomedical materials</subject><subject>Cadavers</subject><subject>Cartilage</subject><subject>Cartilage (articular)</subject><subject>Cartilage diseases</subject><subject>Cell culture</subject><subject>Collagen</subject><subject>Fibril-reinforced poroelastic</subject><subject>Fibrils</subject><subject>Finite element analysis</subject><subject>Joints (anatomy)</subject><subject>Knee</subject><subject>Material properties</subject><subject>Mechanical testing</subject><subject>Microscopy</subject><subject>Optical density</subject><subject>Optical properties</subject><subject>Osteoarthritis</subject><subject>Permeability</subject><subject>Plugs</subject><subject>Proteoglycan</subject><subject>Proteoglycans</subject><subject>Structure-function 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biomechanics</jtitle><date>2021-09-20</date><risdate>2021</risdate><volume>126</volume><spage>110634</spage><epage>110634</epage><pages>110634-110634</pages><artnum>110634</artnum><issn>0021-9290</issn><eissn>1873-2380</eissn><abstract>Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known. Further, the patellofemoral joint loading is thought to include more sliding and shear compared to other knee joint locations, thus, the relations between structural and functional changes may differ in OA. Thus, our aim was to determine the patellar cartilage FRPE properties followed by associating them with the structure and composition. Osteochondral plugs (n = 14) were harvested from the patellae of six cadavers. Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples. The initial fibril network modulus and permeability strain-dependency factor were 72% and 63% smaller in advanced OA samples when compared to early OA samples. Further, we observed a negative association between the initial fibril network modulus and optical retardation (r = -0.537, p < 0.05). We also observed positive associations between 1) the initial permeability and optical retardation (r = 0.547, p < 0.05), and 2) the initial fibril network modulus and optical density (r = 0.670, p < 0.01).These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA. The characterization of these changes is important to improve the representativeness of knee joint models in tissue and cell scale.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.jbiomech.2021.110634</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Arthritis Biomedical materials Cadavers Cartilage Cartilage (articular) Cartilage diseases Cell culture Collagen Fibril-reinforced poroelastic Fibrils Finite element analysis Joints (anatomy) Knee Material properties Mechanical testing Microscopy Optical density Optical properties Osteoarthritis Permeability Plugs Proteoglycan Proteoglycans Structure-function relationships |
| title | Functional and structural properties of human patellar articular cartilage in osteoarthritis |
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