Metabolic profile and tissue distribution of Humantenirine, an oxindole alkaloid from Gelsemium, after oral administration in rats

•The HPLC/QqTOF-MS approach was utilized for the identification of the humantenirine metabolites.•The metabolic profile and tissue distribution of humantenirine in rats were characterized firstly.•A total of 8 metabolites were tentatively identified in vitro and in vivo.•Humantenirine was widely dis...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2021-09, Vol.1181, p.122901-122901, Article 122901
Hauptverfasser:	Qi, Xue-Jia, Zuo, Meng-Ting, Huang, Si-Juan, Ma, Xiao, Wang, Zi-Yuan, Liu, Zhao-Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Alkaloids - administration & dosage Alkaloids - analysis Alkaloids - chemistry Alkaloids - pharmacokinetics Animals Cells, Cultured Chromatography, High Pressure Liquid Distribution Gelsemium Gelsemium - chemistry Humantenirine Male Mass Spectrometry Metabolism Metabolites Metabolome - physiology Microsomes, Liver - metabolism Rats Rats, Sprague-Dawley Tissue Distribution
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