Extensive phylogenies of human development inferred from somatic mutations

Starting from the zygote, all cells in the human body continuously acquire mutations. Mutations shared between different cells imply a common progenitor and are thus naturally occurring markers for lineage tracing 1 , 2 . Here we reconstruct extensive phylogenies of normal tissues from three adult i...

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Veröffentlicht in:	Nature (London) 2021-09, Vol.597 (7876), p.387-392
Hauptverfasser:	Coorens, Tim H. H., Moore, Luiza, Robinson, Philip S., Sanghvi, Rashesh, Christopher, Joseph, Hewinson, James, Przybilla, Moritz J., Lawson, Andrew R. J., Spencer Chapman, Michael, Cagan, Alex, Oliver, Thomas R. W., Neville, Matthew D. C., Hooks, Yvette, Noorani, Ayesha, Mitchell, Thomas J., Fitzgerald, Rebecca C., Campbell, Peter J., Martincorena, Iñigo, Rahbari, Raheleh, Stratton, Michael R.
Format:	Artikel
Sprache:	eng
Schlagworte:	45/23 631/136/2086/1986 631/208/135 631/208/212/2306 Apoptosis Asymmetry Brain - metabolism Cell division Cell Lineage - genetics Chromosomes, Human, Y - genetics Clone Cells - metabolism Cloning Colon Crypts Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Embryogenesis Embryonic Development - genetics Epithelium Gene sequencing Genetic aspects Genomes Genomics Germ cells Germ-Line Mutation - genetics Human growth Humanities and Social Sciences Humans Lasers Male Mosaicism multidisciplinary Mutation Mutation (Biology) Organ Specificity - genetics Pattern formation Phylogeny Physiological aspects Physiological research Polymorphism, Single Nucleotide - genetics Progenitor cells Science Science (multidisciplinary) Somatic cells Whole genome sequencing Zygotes
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