Correlation of Serum Cystatin C with Renal Function in Gout Patients with Renal Injury
The gout-induced continuous deposition of urate in the kidney tissues is the main cause of renal injury, for which cystatin C (Cys C) is an important indicator. This research analyzed the correlation between general renal injury indicators and serum Cys C level, and further investigated the potentia...
Gespeichert in:
| Veröffentlicht in: | Journal of interferon & cytokine research 2021-09, Vol.41 (9), p.329-335 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 335 |
|---|---|
| container_issue | 9 |
| container_start_page | 329 |
| container_title | Journal of interferon & cytokine research |
| container_volume | 41 |
| creator | Wu, Yanqun Wang, Shunhua Xu, Xiaoqing |
| description | The gout-induced continuous deposition of urate in the kidney tissues is the main cause of renal injury, for which cystatin C (Cys C) is an important indicator. This research analyzed the correlation between general renal injury indicators and serum Cys C level, and further investigated the potential of Cys C in renal injury diagnosis. A total of 140 gout patients with renal injury (GRI) were recruited and grouped by their glomerular filtration rate (GFR). Urea nitrogen, uric acid, creatinine, and Cys C levels in the serum were evaluated. The diagnostic efficacy of serum Cys C was evaluated by the nonparametric receiver operating characteristic analysis. Serum Cys C level was increased with decreased GFR in GRI. Urea nitrogen, uric acid, and creatinine levels in the serum showed positive correlations with Cys C level. The area under the curve for serum Cys C was 0.8589 (
|
| doi_str_mv | 10.1089/jir.2021.0034 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2564946201</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2574465194</sourcerecordid><originalsourceid>FETCH-LOGICAL-c321t-f285088347239330d08ae09188874933d2e49275c6b57fcf2ccce9028a281f6c3</originalsourceid><addsrcrecordid>eNpd0E1LwzAYwPEgipvTo1cJePHS-eStSY5S3BQGim_X0GUptnTtTFpk397UTRFPCU9-PIQ_QucEpgSUvq5KP6VAyRSA8QM0JkLIRPJUHMY7SJ1oDXKETkKoACBVVB-jEeOcCSXFGL1lrfeuzruybXBb4Gfn-zXOtqGLowZn-LPs3vGTa_Iaz_rGfrv4MG_7Dj9G45ou_EX3TdX77Sk6KvI6uLP9OUGvs9uX7C5ZPMzvs5tFYhklXVJQJUApxiVlmjFYgcodaKKUkjwOVtRxTaWw6VLIwhbUWus0UJVTRYrUsgm62u3d-Pajd6Ez6zJYV9d549o-GCpSrnlKgUR6-Y9Wbe_jlwcleSxGNI8q2Snr2xC8K8zGl-vcbw0BMwQ3MbgZgpshePQX-639cu1Wv_qnMPsC6S95hA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2574465194</pqid></control><display><type>article</type><title>Correlation of Serum Cystatin C with Renal Function in Gout Patients with Renal Injury</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Wu, Yanqun ; Wang, Shunhua ; Xu, Xiaoqing</creator><creatorcontrib>Wu, Yanqun ; Wang, Shunhua ; Xu, Xiaoqing</creatorcontrib><description>The gout-induced continuous deposition of urate in the kidney tissues is the main cause of renal injury, for which cystatin C (Cys C) is an important indicator. This research analyzed the correlation between general renal injury indicators and serum Cys C level, and further investigated the potential of Cys C in renal injury diagnosis. A total of 140 gout patients with renal injury (GRI) were recruited and grouped by their glomerular filtration rate (GFR). Urea nitrogen, uric acid, creatinine, and Cys C levels in the serum were evaluated. The diagnostic efficacy of serum Cys C was evaluated by the nonparametric receiver operating characteristic analysis. Serum Cys C level was increased with decreased GFR in GRI. Urea nitrogen, uric acid, and creatinine levels in the serum showed positive correlations with Cys C level. The area under the curve for serum Cys C was 0.8589 (
< 0.001). In conclusion, this research demonstrated that the serum Cys C level was a precise diagnostic marker for GFR and renal damage evaluation, and showed a significant diagnostic value for renal injury in patients with gout.</description><identifier>ISSN: 1079-9907</identifier><identifier>EISSN: 1557-7465</identifier><identifier>DOI: 10.1089/jir.2021.0034</identifier><identifier>PMID: 34435875</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Biomarkers - blood ; Creatinine ; Cystatin C ; Cystatin C - blood ; Damage assessment ; Diagnostic systems ; Glomerular filtration rate ; Glomerular Filtration Rate - physiology ; Gout ; Gout - blood ; Gout - physiopathology ; Humans ; Injuries ; Injury analysis ; Kidney - physiopathology ; Kidney Diseases - blood ; Kidney Diseases - physiopathology ; Nitrogen ; Renal function ; Rheumatism ; ROC Curve ; Urea ; Uric acid</subject><ispartof>Journal of interferon & cytokine research, 2021-09, Vol.41 (9), p.329-335</ispartof><rights>Copyright Mary Ann Liebert, Inc. Sep 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-f285088347239330d08ae09188874933d2e49275c6b57fcf2ccce9028a281f6c3</citedby><cites>FETCH-LOGICAL-c321t-f285088347239330d08ae09188874933d2e49275c6b57fcf2ccce9028a281f6c3</cites><orcidid>0000-0002-4946-6536</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34435875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Yanqun</creatorcontrib><creatorcontrib>Wang, Shunhua</creatorcontrib><creatorcontrib>Xu, Xiaoqing</creatorcontrib><title>Correlation of Serum Cystatin C with Renal Function in Gout Patients with Renal Injury</title><title>Journal of interferon & cytokine research</title><addtitle>J Interferon Cytokine Res</addtitle><description>The gout-induced continuous deposition of urate in the kidney tissues is the main cause of renal injury, for which cystatin C (Cys C) is an important indicator. This research analyzed the correlation between general renal injury indicators and serum Cys C level, and further investigated the potential of Cys C in renal injury diagnosis. A total of 140 gout patients with renal injury (GRI) were recruited and grouped by their glomerular filtration rate (GFR). Urea nitrogen, uric acid, creatinine, and Cys C levels in the serum were evaluated. The diagnostic efficacy of serum Cys C was evaluated by the nonparametric receiver operating characteristic analysis. Serum Cys C level was increased with decreased GFR in GRI. Urea nitrogen, uric acid, and creatinine levels in the serum showed positive correlations with Cys C level. The area under the curve for serum Cys C was 0.8589 (
< 0.001). In conclusion, this research demonstrated that the serum Cys C level was a precise diagnostic marker for GFR and renal damage evaluation, and showed a significant diagnostic value for renal injury in patients with gout.</description><subject>Biomarkers - blood</subject><subject>Creatinine</subject><subject>Cystatin C</subject><subject>Cystatin C - blood</subject><subject>Damage assessment</subject><subject>Diagnostic systems</subject><subject>Glomerular filtration rate</subject><subject>Glomerular Filtration Rate - physiology</subject><subject>Gout</subject><subject>Gout - blood</subject><subject>Gout - physiopathology</subject><subject>Humans</subject><subject>Injuries</subject><subject>Injury analysis</subject><subject>Kidney - physiopathology</subject><subject>Kidney Diseases - blood</subject><subject>Kidney Diseases - physiopathology</subject><subject>Nitrogen</subject><subject>Renal function</subject><subject>Rheumatism</subject><subject>ROC Curve</subject><subject>Urea</subject><subject>Uric acid</subject><issn>1079-9907</issn><issn>1557-7465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0E1LwzAYwPEgipvTo1cJePHS-eStSY5S3BQGim_X0GUptnTtTFpk397UTRFPCU9-PIQ_QucEpgSUvq5KP6VAyRSA8QM0JkLIRPJUHMY7SJ1oDXKETkKoACBVVB-jEeOcCSXFGL1lrfeuzruybXBb4Gfn-zXOtqGLowZn-LPs3vGTa_Iaz_rGfrv4MG_7Dj9G45ou_EX3TdX77Sk6KvI6uLP9OUGvs9uX7C5ZPMzvs5tFYhklXVJQJUApxiVlmjFYgcodaKKUkjwOVtRxTaWw6VLIwhbUWus0UJVTRYrUsgm62u3d-Pajd6Ez6zJYV9d549o-GCpSrnlKgUR6-Y9Wbe_jlwcleSxGNI8q2Snr2xC8K8zGl-vcbw0BMwQ3MbgZgpshePQX-639cu1Wv_qnMPsC6S95hA</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Wu, Yanqun</creator><creator>Wang, Shunhua</creator><creator>Xu, Xiaoqing</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4946-6536</orcidid></search><sort><creationdate>202109</creationdate><title>Correlation of Serum Cystatin C with Renal Function in Gout Patients with Renal Injury</title><author>Wu, Yanqun ; Wang, Shunhua ; Xu, Xiaoqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-f285088347239330d08ae09188874933d2e49275c6b57fcf2ccce9028a281f6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biomarkers - blood</topic><topic>Creatinine</topic><topic>Cystatin C</topic><topic>Cystatin C - blood</topic><topic>Damage assessment</topic><topic>Diagnostic systems</topic><topic>Glomerular filtration rate</topic><topic>Glomerular Filtration Rate - physiology</topic><topic>Gout</topic><topic>Gout - blood</topic><topic>Gout - physiopathology</topic><topic>Humans</topic><topic>Injuries</topic><topic>Injury analysis</topic><topic>Kidney - physiopathology</topic><topic>Kidney Diseases - blood</topic><topic>Kidney Diseases - physiopathology</topic><topic>Nitrogen</topic><topic>Renal function</topic><topic>Rheumatism</topic><topic>ROC Curve</topic><topic>Urea</topic><topic>Uric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Yanqun</creatorcontrib><creatorcontrib>Wang, Shunhua</creatorcontrib><creatorcontrib>Xu, Xiaoqing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of interferon & cytokine research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Yanqun</au><au>Wang, Shunhua</au><au>Xu, Xiaoqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of Serum Cystatin C with Renal Function in Gout Patients with Renal Injury</atitle><jtitle>Journal of interferon & cytokine research</jtitle><addtitle>J Interferon Cytokine Res</addtitle><date>2021-09</date><risdate>2021</risdate><volume>41</volume><issue>9</issue><spage>329</spage><epage>335</epage><pages>329-335</pages><issn>1079-9907</issn><eissn>1557-7465</eissn><abstract>The gout-induced continuous deposition of urate in the kidney tissues is the main cause of renal injury, for which cystatin C (Cys C) is an important indicator. This research analyzed the correlation between general renal injury indicators and serum Cys C level, and further investigated the potential of Cys C in renal injury diagnosis. A total of 140 gout patients with renal injury (GRI) were recruited and grouped by their glomerular filtration rate (GFR). Urea nitrogen, uric acid, creatinine, and Cys C levels in the serum were evaluated. The diagnostic efficacy of serum Cys C was evaluated by the nonparametric receiver operating characteristic analysis. Serum Cys C level was increased with decreased GFR in GRI. Urea nitrogen, uric acid, and creatinine levels in the serum showed positive correlations with Cys C level. The area under the curve for serum Cys C was 0.8589 (
< 0.001). In conclusion, this research demonstrated that the serum Cys C level was a precise diagnostic marker for GFR and renal damage evaluation, and showed a significant diagnostic value for renal injury in patients with gout.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>34435875</pmid><doi>10.1089/jir.2021.0034</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4946-6536</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1079-9907 |
| ispartof | Journal of interferon & cytokine research, 2021-09, Vol.41 (9), p.329-335 |
| issn | 1079-9907 1557-7465 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2564946201 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Biomarkers - blood Creatinine Cystatin C Cystatin C - blood Damage assessment Diagnostic systems Glomerular filtration rate Glomerular Filtration Rate - physiology Gout Gout - blood Gout - physiopathology Humans Injuries Injury analysis Kidney - physiopathology Kidney Diseases - blood Kidney Diseases - physiopathology Nitrogen Renal function Rheumatism ROC Curve Urea Uric acid |
| title | Correlation of Serum Cystatin C with Renal Function in Gout Patients with Renal Injury |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T04%3A28%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Correlation%20of%20Serum%20Cystatin%20C%20with%20Renal%20Function%20in%20Gout%20Patients%20with%20Renal%20Injury&rft.jtitle=Journal%20of%20interferon%20&%20cytokine%20research&rft.au=Wu,%20Yanqun&rft.date=2021-09&rft.volume=41&rft.issue=9&rft.spage=329&rft.epage=335&rft.pages=329-335&rft.issn=1079-9907&rft.eissn=1557-7465&rft_id=info:doi/10.1089/jir.2021.0034&rft_dat=%3Cproquest_cross%3E2574465194%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2574465194&rft_id=info:pmid/34435875&rfr_iscdi=true |