Reshaping the murine immunoglobulin heavy chain repertoire with bovine DH genes

Having a limited number of VH segments, cattle rely on uniquely long DH gene segments to generate CDRH3 length variation (3–70 aa) far greater than that in humans or mice. Bovine antibodies with ultralong CDRH3s (>50 aa) possess unusual structures and abilities to bind to special antigens. In thi...

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Veröffentlicht in:	Immunology 2022-01, Vol.165 (1), p.74-87
Hauptverfasser:	Di, Yu, Cai, Shuyi, Zheng, Shunan, Huang, Jinwei, Du, Lijuan, Song, Yu, Zhang, Ming, Wang, Zhao, Yu, Guotao, Ren, Liming, Han, Haitang, Zhao, Yaofeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibody Formation - genetics Antibody Formation - immunology Antigens Autoantibodies B-Lymphocytes - immunology B-Lymphocytes - metabolism B‐cell development Cattle Chains Complementarity Determining Regions - genetics Complementarity Determining Regions - immunology DH gene Evolutionary genetics Gene Targeting Genes Genetic Loci Genetic Vectors - genetics Ig repertoire Immune response Immune response (humoral) Immune system Immunity, Humoral immunoglobulin Immunoglobulin Heavy Chains - genetics Immunoglobulin Heavy Chains - immunology Immunoglobulin Variable Region - genetics Immunoglobulins Mice Mice, Transgenic Segments ultralong CDRH3 V(D)J Recombination
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