Impact of Age and Race on Health-Related Quality of Life Outcomes in Patients Undergoing Radical Prostatectomy for Localized Prostate Cancer
To investigate impact of age and race on health-related quality of life (HRQoL) in men undergoing radical prostatectomy (RP) using a prospectively maintained, racially diverse cohort. The Center for Prostate Disease Research Multicenter National Database was used to identify patients receiving RP fr...
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| Veröffentlicht in: | Urology (Ridgewood, N.J.) N.J.), 2022-05, Vol.163, p.99-106 |
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| creator | Posielski, Natasza Frankel, Jason Kuo, Huai-Ching Ho, On Elsamanoudi, Sally Nousome, Darryl Speir, Ryan Stroup, Sean Musser, John Ernest, Alexander Chesnut, Gregory T. Tausch, Timothy Flores, John Paul Porter, Christopher |
| description | To investigate impact of age and race on health-related quality of life (HRQoL) in men undergoing radical prostatectomy (RP) using a prospectively maintained, racially diverse cohort.
The Center for Prostate Disease Research Multicenter National Database was used to identify patients receiving RP from 2007-2017. The Expanded PCa Index Composite and 36 Item Short-Form Health Survey were completed at baseline and regular intervals. Groups were stratified based on age: 70. Longitudinal patterns in HRQoL were assessed using linear regression models, adjusting for baseline HRQoL, demographics, and clinical characteristics.
In 626 patients undergoing RP, 278 (44.4%) were 70. Older men had worse baseline urinary bother (P |
| doi_str_mv | 10.1016/j.urology.2021.07.034 |
| format | Article |
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The Center for Prostate Disease Research Multicenter National Database was used to identify patients receiving RP from 2007-2017. The Expanded PCa Index Composite and 36 Item Short-Form Health Survey were completed at baseline and regular intervals. Groups were stratified based on age: <60, 60-70, >70. Longitudinal patterns in HRQoL were assessed using linear regression models, adjusting for baseline HRQoL, demographics, and clinical characteristics.
In 626 patients undergoing RP, 278 (44.4%) were <60, 291 (46.5%) were 60-70, 57 (9.1%) were >70. Older men had worse baseline urinary bother (P<.01) and sexual HRQoL (P<.01). Baseline urinary function was similar for older and younger men. Post-RP urinary and sexual HRQoL was significantly lower in men >70. However, when adjusting for baseline HRQoL, race, NCCN risk, and comorbidities, no difference was found between age groups in urinary function or bother, or sexual function. Sexual bother was worse in older men until 48 months post-operatively but subsequently improved to levels similar to younger patients. Race independently affected HRQoL outcomes with older African American men reporting worse urinary function and sexual bother.
When accounting for baseline HRQoL, age does not independently predict worse HRQoL outcomes. Older and younger men experience similar declines in urinary and sexual domain scores after RP. Our findings may be used to better inform patients regarding their expected post RP HRQoL and guide treatment decision-making.</description><identifier>ISSN: 0090-4295</identifier><identifier>EISSN: 1527-9995</identifier><identifier>DOI: 10.1016/j.urology.2021.07.034</identifier><identifier>PMID: 34428537</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><ispartof>Urology (Ridgewood, N.J.), 2022-05, Vol.163, p.99-106</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-f3acf4de8a2618e382c681b83dad5e68af08123e0f3a52bdeeac5d73a99d9cb53</citedby><cites>FETCH-LOGICAL-c365t-f3acf4de8a2618e382c681b83dad5e68af08123e0f3a52bdeeac5d73a99d9cb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0090429521007834$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34428537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Posielski, Natasza</creatorcontrib><creatorcontrib>Frankel, Jason</creatorcontrib><creatorcontrib>Kuo, Huai-Ching</creatorcontrib><creatorcontrib>Ho, On</creatorcontrib><creatorcontrib>Elsamanoudi, Sally</creatorcontrib><creatorcontrib>Nousome, Darryl</creatorcontrib><creatorcontrib>Speir, Ryan</creatorcontrib><creatorcontrib>Stroup, Sean</creatorcontrib><creatorcontrib>Musser, John</creatorcontrib><creatorcontrib>Ernest, Alexander</creatorcontrib><creatorcontrib>Chesnut, Gregory T.</creatorcontrib><creatorcontrib>Tausch, Timothy</creatorcontrib><creatorcontrib>Flores, John Paul</creatorcontrib><creatorcontrib>Porter, Christopher</creatorcontrib><title>Impact of Age and Race on Health-Related Quality of Life Outcomes in Patients Undergoing Radical Prostatectomy for Localized Prostate Cancer</title><title>Urology (Ridgewood, N.J.)</title><addtitle>Urology</addtitle><description>To investigate impact of age and race on health-related quality of life (HRQoL) in men undergoing radical prostatectomy (RP) using a prospectively maintained, racially diverse cohort.
The Center for Prostate Disease Research Multicenter National Database was used to identify patients receiving RP from 2007-2017. The Expanded PCa Index Composite and 36 Item Short-Form Health Survey were completed at baseline and regular intervals. Groups were stratified based on age: <60, 60-70, >70. Longitudinal patterns in HRQoL were assessed using linear regression models, adjusting for baseline HRQoL, demographics, and clinical characteristics.
In 626 patients undergoing RP, 278 (44.4%) were <60, 291 (46.5%) were 60-70, 57 (9.1%) were >70. Older men had worse baseline urinary bother (P<.01) and sexual HRQoL (P<.01). Baseline urinary function was similar for older and younger men. Post-RP urinary and sexual HRQoL was significantly lower in men >70. However, when adjusting for baseline HRQoL, race, NCCN risk, and comorbidities, no difference was found between age groups in urinary function or bother, or sexual function. Sexual bother was worse in older men until 48 months post-operatively but subsequently improved to levels similar to younger patients. Race independently affected HRQoL outcomes with older African American men reporting worse urinary function and sexual bother.
When accounting for baseline HRQoL, age does not independently predict worse HRQoL outcomes. Older and younger men experience similar declines in urinary and sexual domain scores after RP. Our findings may be used to better inform patients regarding their expected post RP HRQoL and guide treatment decision-making.</description><issn>0090-4295</issn><issn>1527-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFkctu2zAQRYmgQeOm_YQUXHYjlQ-RolZFYLRJAAN5oFkTNDlyaUiiS1IB3G_oR4eGnW67GoBz5s7wXoSuKKkpofLrtp5jGMJmXzPCaE3amvDmDC2oYG3VdZ14hxaEdKRqWCcu0IeUtoQQKWX7Hl3wpmFK8HaB_t6NO2MzDj2-3gA2k8NPxgIOE74FM-Rf1RMMJoPDj7MZfN4fyJXvAd_P2YYREvYTfjDZw5QTfp4cxE3w06bIOG_NgB9iSLko2BzGPe5DxKtQ3v2fovnWw0szWYgf0XlvhgSfTvUSPf_4_nN5W63ub-6W16vKcily1XNj-8aBMkxSBVwxKxVdK-6MEyCV6YmijAMpoGBrB2CscC03Xec6uxb8En056u5i-D1Dynr0ycIwmAnCnDQTsmk6rqgqqDiitpyaIvR6F_1o4l5Tog9B6K0-BaEPQWjS6hJEmft8WjGvR3D_pt6cL8C3IwDloy8eok62eGjB-Vi80i74_6x4BWH8n0c</recordid><startdate>202205</startdate><enddate>202205</enddate><creator>Posielski, Natasza</creator><creator>Frankel, Jason</creator><creator>Kuo, Huai-Ching</creator><creator>Ho, On</creator><creator>Elsamanoudi, Sally</creator><creator>Nousome, Darryl</creator><creator>Speir, Ryan</creator><creator>Stroup, Sean</creator><creator>Musser, John</creator><creator>Ernest, Alexander</creator><creator>Chesnut, Gregory T.</creator><creator>Tausch, Timothy</creator><creator>Flores, John Paul</creator><creator>Porter, Christopher</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202205</creationdate><title>Impact of Age and Race on Health-Related Quality of Life Outcomes in Patients Undergoing Radical Prostatectomy for Localized Prostate Cancer</title><author>Posielski, Natasza ; Frankel, Jason ; Kuo, Huai-Ching ; Ho, On ; Elsamanoudi, Sally ; Nousome, Darryl ; Speir, Ryan ; Stroup, Sean ; Musser, John ; Ernest, Alexander ; Chesnut, Gregory T. ; Tausch, Timothy ; Flores, John Paul ; Porter, Christopher</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-f3acf4de8a2618e382c681b83dad5e68af08123e0f3a52bdeeac5d73a99d9cb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Posielski, Natasza</creatorcontrib><creatorcontrib>Frankel, Jason</creatorcontrib><creatorcontrib>Kuo, Huai-Ching</creatorcontrib><creatorcontrib>Ho, On</creatorcontrib><creatorcontrib>Elsamanoudi, Sally</creatorcontrib><creatorcontrib>Nousome, Darryl</creatorcontrib><creatorcontrib>Speir, Ryan</creatorcontrib><creatorcontrib>Stroup, Sean</creatorcontrib><creatorcontrib>Musser, John</creatorcontrib><creatorcontrib>Ernest, Alexander</creatorcontrib><creatorcontrib>Chesnut, Gregory T.</creatorcontrib><creatorcontrib>Tausch, Timothy</creatorcontrib><creatorcontrib>Flores, John Paul</creatorcontrib><creatorcontrib>Porter, Christopher</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Urology (Ridgewood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Posielski, Natasza</au><au>Frankel, Jason</au><au>Kuo, Huai-Ching</au><au>Ho, On</au><au>Elsamanoudi, Sally</au><au>Nousome, Darryl</au><au>Speir, Ryan</au><au>Stroup, Sean</au><au>Musser, John</au><au>Ernest, Alexander</au><au>Chesnut, Gregory T.</au><au>Tausch, Timothy</au><au>Flores, John Paul</au><au>Porter, Christopher</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Age and Race on Health-Related Quality of Life Outcomes in Patients Undergoing Radical Prostatectomy for Localized Prostate Cancer</atitle><jtitle>Urology (Ridgewood, N.J.)</jtitle><addtitle>Urology</addtitle><date>2022-05</date><risdate>2022</risdate><volume>163</volume><spage>99</spage><epage>106</epage><pages>99-106</pages><issn>0090-4295</issn><eissn>1527-9995</eissn><abstract>To investigate impact of age and race on health-related quality of life (HRQoL) in men undergoing radical prostatectomy (RP) using a prospectively maintained, racially diverse cohort.
The Center for Prostate Disease Research Multicenter National Database was used to identify patients receiving RP from 2007-2017. The Expanded PCa Index Composite and 36 Item Short-Form Health Survey were completed at baseline and regular intervals. Groups were stratified based on age: <60, 60-70, >70. Longitudinal patterns in HRQoL were assessed using linear regression models, adjusting for baseline HRQoL, demographics, and clinical characteristics.
In 626 patients undergoing RP, 278 (44.4%) were <60, 291 (46.5%) were 60-70, 57 (9.1%) were >70. Older men had worse baseline urinary bother (P<.01) and sexual HRQoL (P<.01). Baseline urinary function was similar for older and younger men. Post-RP urinary and sexual HRQoL was significantly lower in men >70. However, when adjusting for baseline HRQoL, race, NCCN risk, and comorbidities, no difference was found between age groups in urinary function or bother, or sexual function. Sexual bother was worse in older men until 48 months post-operatively but subsequently improved to levels similar to younger patients. Race independently affected HRQoL outcomes with older African American men reporting worse urinary function and sexual bother.
When accounting for baseline HRQoL, age does not independently predict worse HRQoL outcomes. Older and younger men experience similar declines in urinary and sexual domain scores after RP. Our findings may be used to better inform patients regarding their expected post RP HRQoL and guide treatment decision-making.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34428537</pmid><doi>10.1016/j.urology.2021.07.034</doi><tpages>8</tpages></addata></record> |
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| title | Impact of Age and Race on Health-Related Quality of Life Outcomes in Patients Undergoing Radical Prostatectomy for Localized Prostate Cancer |
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