Identification and quantification of 10 indole/indazole carboxamide synthetic cannabinoids in 36 herbal blends by gas chromatography‐mass spectrometry and nuclear magnetic resonance spectroscopy

Herbal blends containing synthetic cannabinoids have become popular alternatives to marijuana. The number of synthetic cannabinoids and speed of their emergence enable this group of compounds particularly challenging in terms of detection, monitoring, and responding. In this work, both gas chromatog...

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Veröffentlicht in:Journal of forensic sciences 2021-11, Vol.66 (6), p.2156-2166
Hauptverfasser: Liu, Cui‐Mei, Jia, Wei, Meng, Xin, Hua, Zhen‐Dong
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Jia, Wei
Meng, Xin
Hua, Zhen‐Dong
description Herbal blends containing synthetic cannabinoids have become popular alternatives to marijuana. The number of synthetic cannabinoids and speed of their emergence enable this group of compounds particularly challenging in terms of detection, monitoring, and responding. In this work, both gas chromatography‐mass spectrometry (GC‐MS) and nuclear magnetic resonance spectroscopy (NMR) methods were developed for the identification and quantification of synthetic cannabinoids in herbal blends. Ten types of indole/indazole carboxamide synthetic cannabinoids, which showed different types of substitutions connected to nitrogen of the indole/indazole carboxamide, were detected in 36 herbal blends. The GC‐MS fragmentation routes of indole/indazole carboxamide synthetic cannabinoids were discussed in detail for structure identification purpose. The concentration range of synthetic cannabinoid in 36 herbal blends was 1.9–50.6 mg/g using GC‐MS method, while 1.5–49.0 mg/g by NMR method. Nicotine in herbal blends was quantified by NMR method without using reference material, and showed a variation of 5.3–44.7 mg/g. For quantitative analysis, NMR method showed great advantage in the absence of reference material, while GC‐MS method showed great merit for multiple‐compound analysis when reference material was available. Therefore, for the quantitative analysis of new emerged synthetic cannabinoid in herbal blends, different methods could be chosen by considering whether reference material is available, as well as the number and types of synthetic cannabinoids detected in a single sample.
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The number of synthetic cannabinoids and speed of their emergence enable this group of compounds particularly challenging in terms of detection, monitoring, and responding. In this work, both gas chromatography‐mass spectrometry (GC‐MS) and nuclear magnetic resonance spectroscopy (NMR) methods were developed for the identification and quantification of synthetic cannabinoids in herbal blends. Ten types of indole/indazole carboxamide synthetic cannabinoids, which showed different types of substitutions connected to nitrogen of the indole/indazole carboxamide, were detected in 36 herbal blends. The GC‐MS fragmentation routes of indole/indazole carboxamide synthetic cannabinoids were discussed in detail for structure identification purpose. The concentration range of synthetic cannabinoid in 36 herbal blends was 1.9–50.6 mg/g using GC‐MS method, while 1.5–49.0 mg/g by NMR method. Nicotine in herbal blends was quantified by NMR method without using reference material, and showed a variation of 5.3–44.7 mg/g. For quantitative analysis, NMR method showed great advantage in the absence of reference material, while GC‐MS method showed great merit for multiple‐compound analysis when reference material was available. 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The number of synthetic cannabinoids and speed of their emergence enable this group of compounds particularly challenging in terms of detection, monitoring, and responding. In this work, both gas chromatography‐mass spectrometry (GC‐MS) and nuclear magnetic resonance spectroscopy (NMR) methods were developed for the identification and quantification of synthetic cannabinoids in herbal blends. Ten types of indole/indazole carboxamide synthetic cannabinoids, which showed different types of substitutions connected to nitrogen of the indole/indazole carboxamide, were detected in 36 herbal blends. The GC‐MS fragmentation routes of indole/indazole carboxamide synthetic cannabinoids were discussed in detail for structure identification purpose. The concentration range of synthetic cannabinoid in 36 herbal blends was 1.9–50.6 mg/g using GC‐MS method, while 1.5–49.0 mg/g by NMR method. 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subjects Chromatography
Gas chromatography
gas chromatography‐mass spectrometry
herbal blend
Marijuana
Mass spectrometry
Mixtures
new psychoactive substance
Nicotine
NMR
NMR spectroscopy
Nuclear magnetic resonance
nuclear magnetic resonance spectroscopy
Psychotropic drugs
qualitative analysis
Quantitative analysis
Reference materials
Scientific imaging
synthetic cannabinoid
title Identification and quantification of 10 indole/indazole carboxamide synthetic cannabinoids in 36 herbal blends by gas chromatography‐mass spectrometry and nuclear magnetic resonance spectroscopy
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