Exploring immunogenicity of tick salivary AV422 protein in persons exposed to ticks: prospects for utilization
In order to determine whether conserved tick salivary protein AV422 is immunogenic, the goal of our study was to detect specific IgG response within at-risk populations. Study groups included 76 individuals, differing in occurrence of recently recorded tick bites and health status. Western blotting...
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Veröffentlicht in: | Experimental & applied acarology 2021-09, Vol.85 (1), p.83-99 |
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creator | Mihaljica, Darko Marković, Dragana Repac, Jelena Božić, Bojan Radulović, Željko Veinović, Gorana Sukara, Ratko Ristanović, Elizabeta Chochlakis, Dimosthenis Nedeljković, Biljana Božić Tomanović, Snežana |
description | In order to determine whether conserved tick salivary protein AV422 is immunogenic, the goal of our study was to detect specific IgG response within at-risk populations. Study groups included 76 individuals, differing in occurrence of recently recorded tick bites and health status. Western blotting with recombinant (r) protein derived from
Ixodes ricinus
(
Ir
) was performed. IgG response to
Borrelia
/
Rickettsia
, as indicators of previous tick infestations, was also assessed. Additionally, a detailed in silico AV422 protein sequence analysis was performed, followed by modelling of the interactions between peptides and corresponding MHC II molecules by molecular docking. Anti-r
Ir
AV422 seroprevalences among individuals exposed to ticks were high (62.5, 57.9 and 66.7%) and anti-
Borrelia
/
Rickettsia
seroprevalences were 54.2, 15.8 and 44.4% among individuals with/without recent tick bite and patients suspected of tick-borne disease, respectively. In silico analysis of AV422 protein sequence showed a high level of conservation across tick genera, including also the predicted antigenic determinants specific for T and B cells. Docking to the restricted MHC II molecules was performed for all predicted AV422 T cell epitopes, and the most potent (highly immunogenic) epitope determinants were suggested. The epitope prediction reveals that tick salivary protein AV422 may elicit humoral immune response in humans, which is consistent with the high anti-r
Ir
AV422 seroprevalence in tested at-risk subjects. Tick-borne diseases are a growing public health concern worldwide, and AV422 is potentially useful in clinical practice and epidemiological studies. |
doi_str_mv | 10.1007/s10493-021-00653-z |
format | Article |
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Ixodes ricinus
(
Ir
) was performed. IgG response to
Borrelia
/
Rickettsia
, as indicators of previous tick infestations, was also assessed. Additionally, a detailed in silico AV422 protein sequence analysis was performed, followed by modelling of the interactions between peptides and corresponding MHC II molecules by molecular docking. Anti-r
Ir
AV422 seroprevalences among individuals exposed to ticks were high (62.5, 57.9 and 66.7%) and anti-
Borrelia
/
Rickettsia
seroprevalences were 54.2, 15.8 and 44.4% among individuals with/without recent tick bite and patients suspected of tick-borne disease, respectively. In silico analysis of AV422 protein sequence showed a high level of conservation across tick genera, including also the predicted antigenic determinants specific for T and B cells. Docking to the restricted MHC II molecules was performed for all predicted AV422 T cell epitopes, and the most potent (highly immunogenic) epitope determinants were suggested. The epitope prediction reveals that tick salivary protein AV422 may elicit humoral immune response in humans, which is consistent with the high anti-r
Ir
AV422 seroprevalence in tested at-risk subjects. Tick-borne diseases are a growing public health concern worldwide, and AV422 is potentially useful in clinical practice and epidemiological studies.</description><identifier>ISSN: 0168-8162</identifier><identifier>EISSN: 1572-9702</identifier><identifier>DOI: 10.1007/s10493-021-00653-z</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Amino acid sequence ; Animal Ecology ; Animal Genetics and Genomics ; Animal Systematics/Taxonomy/Biogeography ; Antigenic determinants ; Antigens ; Arachnids ; Biomedical and Life Sciences ; Borrelia ; Conserved sequence ; Entomology ; Epidemiology ; Epitopes ; Immune response ; Immune response (humoral) ; Immune system ; Immunogenicity ; Immunoglobulin G ; Insect bites ; Life Sciences ; Lymphocytes ; Lymphocytes B ; Lymphocytes T ; Major histocompatibility complex ; Molecular docking ; Parasitic diseases ; Peptides ; Population studies ; Proteins ; Public health ; Rickettsia ; Sequence analysis ; Serology ; Tick-borne diseases ; Ticks ; Western blotting</subject><ispartof>Experimental & applied acarology, 2021-09, Vol.85 (1), p.83-99</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021</rights><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-193be95b1c4297cfe18287b65e7c670a258ee23a4e19cea9c3e095bed37201af3</citedby><cites>FETCH-LOGICAL-c352t-193be95b1c4297cfe18287b65e7c670a258ee23a4e19cea9c3e095bed37201af3</cites><orcidid>0000-0002-9673-1769</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10493-021-00653-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10493-021-00653-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Mihaljica, Darko</creatorcontrib><creatorcontrib>Marković, Dragana</creatorcontrib><creatorcontrib>Repac, Jelena</creatorcontrib><creatorcontrib>Božić, Bojan</creatorcontrib><creatorcontrib>Radulović, Željko</creatorcontrib><creatorcontrib>Veinović, Gorana</creatorcontrib><creatorcontrib>Sukara, Ratko</creatorcontrib><creatorcontrib>Ristanović, Elizabeta</creatorcontrib><creatorcontrib>Chochlakis, Dimosthenis</creatorcontrib><creatorcontrib>Nedeljković, Biljana Božić</creatorcontrib><creatorcontrib>Tomanović, Snežana</creatorcontrib><title>Exploring immunogenicity of tick salivary AV422 protein in persons exposed to ticks: prospects for utilization</title><title>Experimental & applied acarology</title><addtitle>Exp Appl Acarol</addtitle><description>In order to determine whether conserved tick salivary protein AV422 is immunogenic, the goal of our study was to detect specific IgG response within at-risk populations. Study groups included 76 individuals, differing in occurrence of recently recorded tick bites and health status. Western blotting with recombinant (r) protein derived from
Ixodes ricinus
(
Ir
) was performed. IgG response to
Borrelia
/
Rickettsia
, as indicators of previous tick infestations, was also assessed. Additionally, a detailed in silico AV422 protein sequence analysis was performed, followed by modelling of the interactions between peptides and corresponding MHC II molecules by molecular docking. Anti-r
Ir
AV422 seroprevalences among individuals exposed to ticks were high (62.5, 57.9 and 66.7%) and anti-
Borrelia
/
Rickettsia
seroprevalences were 54.2, 15.8 and 44.4% among individuals with/without recent tick bite and patients suspected of tick-borne disease, respectively. In silico analysis of AV422 protein sequence showed a high level of conservation across tick genera, including also the predicted antigenic determinants specific for T and B cells. Docking to the restricted MHC II molecules was performed for all predicted AV422 T cell epitopes, and the most potent (highly immunogenic) epitope determinants were suggested. The epitope prediction reveals that tick salivary protein AV422 may elicit humoral immune response in humans, which is consistent with the high anti-r
Ir
AV422 seroprevalence in tested at-risk subjects. Tick-borne diseases are a growing public health concern worldwide, and AV422 is potentially useful in clinical practice and epidemiological studies.</description><subject>Amino acid sequence</subject><subject>Animal Ecology</subject><subject>Animal Genetics and Genomics</subject><subject>Animal Systematics/Taxonomy/Biogeography</subject><subject>Antigenic determinants</subject><subject>Antigens</subject><subject>Arachnids</subject><subject>Biomedical and Life Sciences</subject><subject>Borrelia</subject><subject>Conserved sequence</subject><subject>Entomology</subject><subject>Epidemiology</subject><subject>Epitopes</subject><subject>Immune response</subject><subject>Immune response (humoral)</subject><subject>Immune system</subject><subject>Immunogenicity</subject><subject>Immunoglobulin G</subject><subject>Insect bites</subject><subject>Life Sciences</subject><subject>Lymphocytes</subject><subject>Lymphocytes B</subject><subject>Lymphocytes T</subject><subject>Major histocompatibility complex</subject><subject>Molecular docking</subject><subject>Parasitic diseases</subject><subject>Peptides</subject><subject>Population studies</subject><subject>Proteins</subject><subject>Public health</subject><subject>Rickettsia</subject><subject>Sequence analysis</subject><subject>Serology</subject><subject>Tick-borne diseases</subject><subject>Ticks</subject><subject>Western 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immunogenicity of tick salivary AV422 protein in persons exposed to ticks: prospects for utilization</title><author>Mihaljica, Darko ; Marković, Dragana ; Repac, Jelena ; Božić, Bojan ; Radulović, Željko ; Veinović, Gorana ; Sukara, Ratko ; Ristanović, Elizabeta ; Chochlakis, Dimosthenis ; Nedeljković, Biljana Božić ; Tomanović, Snežana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-193be95b1c4297cfe18287b65e7c670a258ee23a4e19cea9c3e095bed37201af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Amino acid sequence</topic><topic>Animal Ecology</topic><topic>Animal Genetics and Genomics</topic><topic>Animal Systematics/Taxonomy/Biogeography</topic><topic>Antigenic determinants</topic><topic>Antigens</topic><topic>Arachnids</topic><topic>Biomedical and Life Sciences</topic><topic>Borrelia</topic><topic>Conserved sequence</topic><topic>Entomology</topic><topic>Epidemiology</topic><topic>Epitopes</topic><topic>Immune response</topic><topic>Immune response (humoral)</topic><topic>Immune system</topic><topic>Immunogenicity</topic><topic>Immunoglobulin G</topic><topic>Insect bites</topic><topic>Life Sciences</topic><topic>Lymphocytes</topic><topic>Lymphocytes B</topic><topic>Lymphocytes T</topic><topic>Major histocompatibility complex</topic><topic>Molecular docking</topic><topic>Parasitic diseases</topic><topic>Peptides</topic><topic>Population studies</topic><topic>Proteins</topic><topic>Public health</topic><topic>Rickettsia</topic><topic>Sequence analysis</topic><topic>Serology</topic><topic>Tick-borne diseases</topic><topic>Ticks</topic><topic>Western blotting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mihaljica, Darko</creatorcontrib><creatorcontrib>Marković, Dragana</creatorcontrib><creatorcontrib>Repac, 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utilization</atitle><jtitle>Experimental & applied acarology</jtitle><stitle>Exp Appl Acarol</stitle><date>2021-09-01</date><risdate>2021</risdate><volume>85</volume><issue>1</issue><spage>83</spage><epage>99</epage><pages>83-99</pages><issn>0168-8162</issn><eissn>1572-9702</eissn><abstract>In order to determine whether conserved tick salivary protein AV422 is immunogenic, the goal of our study was to detect specific IgG response within at-risk populations. Study groups included 76 individuals, differing in occurrence of recently recorded tick bites and health status. Western blotting with recombinant (r) protein derived from
Ixodes ricinus
(
Ir
) was performed. IgG response to
Borrelia
/
Rickettsia
, as indicators of previous tick infestations, was also assessed. Additionally, a detailed in silico AV422 protein sequence analysis was performed, followed by modelling of the interactions between peptides and corresponding MHC II molecules by molecular docking. Anti-r
Ir
AV422 seroprevalences among individuals exposed to ticks were high (62.5, 57.9 and 66.7%) and anti-
Borrelia
/
Rickettsia
seroprevalences were 54.2, 15.8 and 44.4% among individuals with/without recent tick bite and patients suspected of tick-borne disease, respectively. In silico analysis of AV422 protein sequence showed a high level of conservation across tick genera, including also the predicted antigenic determinants specific for T and B cells. Docking to the restricted MHC II molecules was performed for all predicted AV422 T cell epitopes, and the most potent (highly immunogenic) epitope determinants were suggested. The epitope prediction reveals that tick salivary protein AV422 may elicit humoral immune response in humans, which is consistent with the high anti-r
Ir
AV422 seroprevalence in tested at-risk subjects. Tick-borne diseases are a growing public health concern worldwide, and AV422 is potentially useful in clinical practice and epidemiological studies.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s10493-021-00653-z</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-9673-1769</orcidid></addata></record> |
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language | eng |
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source | SpringerNature Journals |
subjects | Amino acid sequence Animal Ecology Animal Genetics and Genomics Animal Systematics/Taxonomy/Biogeography Antigenic determinants Antigens Arachnids Biomedical and Life Sciences Borrelia Conserved sequence Entomology Epidemiology Epitopes Immune response Immune response (humoral) Immune system Immunogenicity Immunoglobulin G Insect bites Life Sciences Lymphocytes Lymphocytes B Lymphocytes T Major histocompatibility complex Molecular docking Parasitic diseases Peptides Population studies Proteins Public health Rickettsia Sequence analysis Serology Tick-borne diseases Ticks Western blotting |
title | Exploring immunogenicity of tick salivary AV422 protein in persons exposed to ticks: prospects for utilization |
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