Comparison between dynamic whole-body FDG-PET and early-delayed imaging for the assessment of motion in focal uptake in colorectal area
Objectives Serial changes of focal uptake in whole-body dynamic positron emission tomography (PET) imaging were assessed and compared with those in early-delayed imaging to differentiate pathological uptake from physiological uptake in the colorectal area, based on the change in uptake shape. Method...
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| Veröffentlicht in: | Annals of nuclear medicine 2021-12, Vol.35 (12), p.1305-1311 |
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| creator | Kotani, Tomoya Nishimura, Motoki Tamaki, Nagara Matsushima, Shigenori Akiyama, Shimpei Kanayama, Taisei Bamba, Chisa Tanada, Yasutomo Nii, Takeshi Yamada, Kei |
| description | Objectives
Serial changes of focal uptake in whole-body dynamic positron emission tomography (PET) imaging were assessed and compared with those in early-delayed imaging to differentiate pathological uptake from physiological uptake in the colorectal area, based on the change in uptake shape.
Methods
In 60 patients with at least 1 pathologically diagnosed colorectal cancer or adenoma, a serial 3 min dynamic whole-body PET/computed tomography imaging was performed four times around 60 min after the administration of
18
F-fluorodeoxyglucose (FDG) to create a conventional (early) image by summation. Delayed imaging was performed separately at 110 min after FDG administration. High focal uptake lesions in the colorectal area were visually assessed as “changed” or “unchanged” on serial dynamic imaging and early-delayed imaging, based on the alteration in uptake shape over time. These criteria on the images were used to differentiate pathological uptake from physiological uptake.
Results
In this study, 334 lesions with high focal FDG uptake were observed. Among 73 histologically proven pathological FDG uptakes, no change was observed in 69 on serial dynamic imaging and 72 on early-delayed imaging (sensitivity of 95 vs. 99%, respectively; ns). In contrast, out of 261 physiological FDG uptakes, a change in uptake shape was seen in 159 on dynamic PET imaging and 66 on early-delayed imaging (specificity of 61 vs. 25%, respectively;
p
|
| doi_str_mv | 10.1007/s12149-021-01671-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2564135562</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2589193051</sourcerecordid><originalsourceid>FETCH-LOGICAL-c520t-fcd36b0c4fc96d16743d3eab71e152f43d983d941770e24b20c278063dc029c83</originalsourceid><addsrcrecordid>eNp9kctO3TAQhq2qVTnQvgCLylI3bEx9i-Ms0Sk3CaksYG059uQQmtgHOxHKE_S1MRxoJRZdWKPxfPOPxz9Ch4weM0rrH5lxJhtCOSOUqZqR5QNaMa0kUVKIj2hFGyZJzXS9h_ZzvqeU60rzz2hPSMmVbugK_VnHcWtTn2PALUyPAAH7Jdixd_jxLg5A2ugXfPbznFyf3mAbPAabhoV4GOwCHvej3fRhg7uY8HQH2OYMOY8QJhw7PMapL8p9KHVnBzxvJ_sbnnMXh5jATeXSJrBf0KfODhm-vsYDdHt2erO-IFe_zi_XJ1fEVZxOpHNeqJY62blG-bK0FF6AbWsGrOJdyRpdjmR1TYHLllPHa02V8I7yxmlxgI52utsUH2bIkxn77GAYbIA4Z8MrJZmoKsUL-v0deh_nFMrrCqUb1ghasULxHeVSzDlBZ7ap_ElaDKPm2Sazs8kUm8yLTWYpTd9eped2BP-35c2XAogdkEspbCD9m_0f2SfcMp4_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2589193051</pqid></control><display><type>article</type><title>Comparison between dynamic whole-body FDG-PET and early-delayed imaging for the assessment of motion in focal uptake in colorectal area</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Kotani, Tomoya ; Nishimura, Motoki ; Tamaki, Nagara ; Matsushima, Shigenori ; Akiyama, Shimpei ; Kanayama, Taisei ; Bamba, Chisa ; Tanada, Yasutomo ; Nii, Takeshi ; Yamada, Kei</creator><creatorcontrib>Kotani, Tomoya ; Nishimura, Motoki ; Tamaki, Nagara ; Matsushima, Shigenori ; Akiyama, Shimpei ; Kanayama, Taisei ; Bamba, Chisa ; Tanada, Yasutomo ; Nii, Takeshi ; Yamada, Kei</creatorcontrib><description>Objectives
Serial changes of focal uptake in whole-body dynamic positron emission tomography (PET) imaging were assessed and compared with those in early-delayed imaging to differentiate pathological uptake from physiological uptake in the colorectal area, based on the change in uptake shape.
Methods
In 60 patients with at least 1 pathologically diagnosed colorectal cancer or adenoma, a serial 3 min dynamic whole-body PET/computed tomography imaging was performed four times around 60 min after the administration of
18
F-fluorodeoxyglucose (FDG) to create a conventional (early) image by summation. Delayed imaging was performed separately at 110 min after FDG administration. High focal uptake lesions in the colorectal area were visually assessed as “changed” or “unchanged” on serial dynamic imaging and early-delayed imaging, based on the alteration in uptake shape over time. These criteria on the images were used to differentiate pathological uptake from physiological uptake.
Results
In this study, 334 lesions with high focal FDG uptake were observed. Among 73 histologically proven pathological FDG uptakes, no change was observed in 69 on serial dynamic imaging and 72 on early-delayed imaging (sensitivity of 95 vs. 99%, respectively; ns). In contrast, out of 261 physiological FDG uptakes, a change in uptake shape was seen in 159 on dynamic PET imaging and 66 on early-delayed imaging (specificity of 61 vs. 25%, respectively;
p
< 0.01). High and similar negative predictive values for identifying pathological uptake were obtained by both methods (98 vs 99%, respectively). Thus, the overall accuracy for differentiating pathological from physiological FDG uptake based on change in uptake shape tended to be higher on serial dynamic imaging (68%) than on early-delayed imaging (41%;
p
< 0.01).
Conclusions
Dynamic whole-body FDG imaging enables differentiation of pathological uptake from physiological uptake based on the serial changes in uptake shape in the colorectal area. It may provide greater diagnostic value than early-delayed PET imaging. Thus, this technique holds a promise for minimizing the need for delayed imaging.</description><identifier>ISSN: 0914-7187</identifier><identifier>ISSN: 1864-6433</identifier><identifier>EISSN: 1864-6433</identifier><identifier>DOI: 10.1007/s12149-021-01671-y</identifier><identifier>PMID: 34426890</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Adenoma ; Adult ; Aged ; Aged, 80 and over ; Biological Transport ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - diagnostic imaging ; Colorectal Neoplasms - metabolism ; Computed tomography ; Emission analysis ; Female ; Fluorodeoxyglucose F18 ; Humans ; Imaging ; Lesions ; Male ; Medical imaging ; Medicine ; Medicine & Public Health ; Middle Aged ; Motion ; Movement ; Nuclear Medicine ; Original Article ; Physiology ; Positron emission ; Positron emission tomography ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography - methods ; Radiology ; Time Factors ; Tomography ; Whole Body Imaging - methods</subject><ispartof>Annals of nuclear medicine, 2021-12, Vol.35 (12), p.1305-1311</ispartof><rights>The Japanese Society of Nuclear Medicine 2021</rights><rights>2021. The Japanese Society of Nuclear Medicine.</rights><rights>The Japanese Society of Nuclear Medicine 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-fcd36b0c4fc96d16743d3eab71e152f43d983d941770e24b20c278063dc029c83</citedby><cites>FETCH-LOGICAL-c520t-fcd36b0c4fc96d16743d3eab71e152f43d983d941770e24b20c278063dc029c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12149-021-01671-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12149-021-01671-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34426890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kotani, Tomoya</creatorcontrib><creatorcontrib>Nishimura, Motoki</creatorcontrib><creatorcontrib>Tamaki, Nagara</creatorcontrib><creatorcontrib>Matsushima, Shigenori</creatorcontrib><creatorcontrib>Akiyama, Shimpei</creatorcontrib><creatorcontrib>Kanayama, Taisei</creatorcontrib><creatorcontrib>Bamba, Chisa</creatorcontrib><creatorcontrib>Tanada, Yasutomo</creatorcontrib><creatorcontrib>Nii, Takeshi</creatorcontrib><creatorcontrib>Yamada, Kei</creatorcontrib><title>Comparison between dynamic whole-body FDG-PET and early-delayed imaging for the assessment of motion in focal uptake in colorectal area</title><title>Annals of nuclear medicine</title><addtitle>Ann Nucl Med</addtitle><addtitle>Ann Nucl Med</addtitle><description>Objectives
Serial changes of focal uptake in whole-body dynamic positron emission tomography (PET) imaging were assessed and compared with those in early-delayed imaging to differentiate pathological uptake from physiological uptake in the colorectal area, based on the change in uptake shape.
Methods
In 60 patients with at least 1 pathologically diagnosed colorectal cancer or adenoma, a serial 3 min dynamic whole-body PET/computed tomography imaging was performed four times around 60 min after the administration of
18
F-fluorodeoxyglucose (FDG) to create a conventional (early) image by summation. Delayed imaging was performed separately at 110 min after FDG administration. High focal uptake lesions in the colorectal area were visually assessed as “changed” or “unchanged” on serial dynamic imaging and early-delayed imaging, based on the alteration in uptake shape over time. These criteria on the images were used to differentiate pathological uptake from physiological uptake.
Results
In this study, 334 lesions with high focal FDG uptake were observed. Among 73 histologically proven pathological FDG uptakes, no change was observed in 69 on serial dynamic imaging and 72 on early-delayed imaging (sensitivity of 95 vs. 99%, respectively; ns). In contrast, out of 261 physiological FDG uptakes, a change in uptake shape was seen in 159 on dynamic PET imaging and 66 on early-delayed imaging (specificity of 61 vs. 25%, respectively;
p
< 0.01). High and similar negative predictive values for identifying pathological uptake were obtained by both methods (98 vs 99%, respectively). Thus, the overall accuracy for differentiating pathological from physiological FDG uptake based on change in uptake shape tended to be higher on serial dynamic imaging (68%) than on early-delayed imaging (41%;
p
< 0.01).
Conclusions
Dynamic whole-body FDG imaging enables differentiation of pathological uptake from physiological uptake based on the serial changes in uptake shape in the colorectal area. It may provide greater diagnostic value than early-delayed PET imaging. Thus, this technique holds a promise for minimizing the need for delayed imaging.</description><subject>Adenoma</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological Transport</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - diagnostic imaging</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Computed tomography</subject><subject>Emission analysis</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Imaging</subject><subject>Lesions</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Motion</subject><subject>Movement</subject><subject>Nuclear Medicine</subject><subject>Original Article</subject><subject>Physiology</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Positron Emission Tomography Computed Tomography</subject><subject>Positron-Emission Tomography - methods</subject><subject>Radiology</subject><subject>Time Factors</subject><subject>Tomography</subject><subject>Whole Body Imaging - methods</subject><issn>0914-7187</issn><issn>1864-6433</issn><issn>1864-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctO3TAQhq2qVTnQvgCLylI3bEx9i-Ms0Sk3CaksYG059uQQmtgHOxHKE_S1MRxoJRZdWKPxfPOPxz9Ch4weM0rrH5lxJhtCOSOUqZqR5QNaMa0kUVKIj2hFGyZJzXS9h_ZzvqeU60rzz2hPSMmVbugK_VnHcWtTn2PALUyPAAH7Jdixd_jxLg5A2ugXfPbznFyf3mAbPAabhoV4GOwCHvej3fRhg7uY8HQH2OYMOY8QJhw7PMapL8p9KHVnBzxvJ_sbnnMXh5jATeXSJrBf0KfODhm-vsYDdHt2erO-IFe_zi_XJ1fEVZxOpHNeqJY62blG-bK0FF6AbWsGrOJdyRpdjmR1TYHLllPHa02V8I7yxmlxgI52utsUH2bIkxn77GAYbIA4Z8MrJZmoKsUL-v0deh_nFMrrCqUb1ghasULxHeVSzDlBZ7ap_ElaDKPm2Sazs8kUm8yLTWYpTd9eped2BP-35c2XAogdkEspbCD9m_0f2SfcMp4_</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Kotani, Tomoya</creator><creator>Nishimura, Motoki</creator><creator>Tamaki, Nagara</creator><creator>Matsushima, Shigenori</creator><creator>Akiyama, Shimpei</creator><creator>Kanayama, Taisei</creator><creator>Bamba, Chisa</creator><creator>Tanada, Yasutomo</creator><creator>Nii, Takeshi</creator><creator>Yamada, Kei</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20211201</creationdate><title>Comparison between dynamic whole-body FDG-PET and early-delayed imaging for the assessment of motion in focal uptake in colorectal area</title><author>Kotani, Tomoya ; Nishimura, Motoki ; Tamaki, Nagara ; Matsushima, Shigenori ; Akiyama, Shimpei ; Kanayama, Taisei ; Bamba, Chisa ; Tanada, Yasutomo ; Nii, Takeshi ; Yamada, Kei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-fcd36b0c4fc96d16743d3eab71e152f43d983d941770e24b20c278063dc029c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adenoma</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological Transport</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - diagnostic imaging</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Computed tomography</topic><topic>Emission analysis</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Imaging</topic><topic>Lesions</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Motion</topic><topic>Movement</topic><topic>Nuclear Medicine</topic><topic>Original Article</topic><topic>Physiology</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Positron Emission Tomography Computed Tomography</topic><topic>Positron-Emission Tomography - methods</topic><topic>Radiology</topic><topic>Time Factors</topic><topic>Tomography</topic><topic>Whole Body Imaging - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kotani, Tomoya</creatorcontrib><creatorcontrib>Nishimura, Motoki</creatorcontrib><creatorcontrib>Tamaki, Nagara</creatorcontrib><creatorcontrib>Matsushima, Shigenori</creatorcontrib><creatorcontrib>Akiyama, Shimpei</creatorcontrib><creatorcontrib>Kanayama, Taisei</creatorcontrib><creatorcontrib>Bamba, Chisa</creatorcontrib><creatorcontrib>Tanada, Yasutomo</creatorcontrib><creatorcontrib>Nii, Takeshi</creatorcontrib><creatorcontrib>Yamada, Kei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kotani, Tomoya</au><au>Nishimura, Motoki</au><au>Tamaki, Nagara</au><au>Matsushima, Shigenori</au><au>Akiyama, Shimpei</au><au>Kanayama, Taisei</au><au>Bamba, Chisa</au><au>Tanada, Yasutomo</au><au>Nii, Takeshi</au><au>Yamada, Kei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison between dynamic whole-body FDG-PET and early-delayed imaging for the assessment of motion in focal uptake in colorectal area</atitle><jtitle>Annals of nuclear medicine</jtitle><stitle>Ann Nucl Med</stitle><addtitle>Ann Nucl Med</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>35</volume><issue>12</issue><spage>1305</spage><epage>1311</epage><pages>1305-1311</pages><issn>0914-7187</issn><issn>1864-6433</issn><eissn>1864-6433</eissn><abstract>Objectives
Serial changes of focal uptake in whole-body dynamic positron emission tomography (PET) imaging were assessed and compared with those in early-delayed imaging to differentiate pathological uptake from physiological uptake in the colorectal area, based on the change in uptake shape.
Methods
In 60 patients with at least 1 pathologically diagnosed colorectal cancer or adenoma, a serial 3 min dynamic whole-body PET/computed tomography imaging was performed four times around 60 min after the administration of
18
F-fluorodeoxyglucose (FDG) to create a conventional (early) image by summation. Delayed imaging was performed separately at 110 min after FDG administration. High focal uptake lesions in the colorectal area were visually assessed as “changed” or “unchanged” on serial dynamic imaging and early-delayed imaging, based on the alteration in uptake shape over time. These criteria on the images were used to differentiate pathological uptake from physiological uptake.
Results
In this study, 334 lesions with high focal FDG uptake were observed. Among 73 histologically proven pathological FDG uptakes, no change was observed in 69 on serial dynamic imaging and 72 on early-delayed imaging (sensitivity of 95 vs. 99%, respectively; ns). In contrast, out of 261 physiological FDG uptakes, a change in uptake shape was seen in 159 on dynamic PET imaging and 66 on early-delayed imaging (specificity of 61 vs. 25%, respectively;
p
< 0.01). High and similar negative predictive values for identifying pathological uptake were obtained by both methods (98 vs 99%, respectively). Thus, the overall accuracy for differentiating pathological from physiological FDG uptake based on change in uptake shape tended to be higher on serial dynamic imaging (68%) than on early-delayed imaging (41%;
p
< 0.01).
Conclusions
Dynamic whole-body FDG imaging enables differentiation of pathological uptake from physiological uptake based on the serial changes in uptake shape in the colorectal area. It may provide greater diagnostic value than early-delayed PET imaging. Thus, this technique holds a promise for minimizing the need for delayed imaging.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>34426890</pmid><doi>10.1007/s12149-021-01671-y</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0914-7187 |
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| subjects | Adenoma Adult Aged Aged, 80 and over Biological Transport Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - diagnostic imaging Colorectal Neoplasms - metabolism Computed tomography Emission analysis Female Fluorodeoxyglucose F18 Humans Imaging Lesions Male Medical imaging Medicine Medicine & Public Health Middle Aged Motion Movement Nuclear Medicine Original Article Physiology Positron emission Positron emission tomography Positron Emission Tomography Computed Tomography Positron-Emission Tomography - methods Radiology Time Factors Tomography Whole Body Imaging - methods |
| title | Comparison between dynamic whole-body FDG-PET and early-delayed imaging for the assessment of motion in focal uptake in colorectal area |
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