A recombinant selective drug-resistant M. bovis BCG enhances the bactericidal activity of a second-line anti-tuberculosis regimen

Drug-resistant tuberculosis (DR-TB) poses a new threat to global health; to improve the treatment outcome, therapeutic vaccines are considered the best chemotherapy adjuvants. Unfortunately, there is no therapeutic vaccine approved against DR-TB. Our study assessed the therapeutic efficacy of a reco...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2021-10, Vol.142, p.112047-112047, Article 112047
Hauptverfasser:	Chiwala, Gift, Liu, Zhiyong, Mugweru, Julius N., Wang, Bangxing, Khan, Shahzad Akbar, Bate, Petuel Ndip Ndip, Yusuf, Buhari, Hameed, H.M. Adnan, Fang, Cuiting, Tan, Yaoju, Guan, Ping, Hu, Jinxing, Tan, Shouyong, Liu, Jianxiong, Zhong, Nanshan, Zhang, Tianyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Ag85B Amikacin - pharmacology Amikacin - therapeutic use Animals Antigens, Bacterial - biosynthesis Antigens, Bacterial - genetics Antigens, Bacterial - immunology Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use BCG Vaccine - biosynthesis BCG Vaccine - genetics BCG Vaccine - immunology BCG Vaccine - therapeutic use Disease Models, Animal Drug Resistance, Bacterial - genetics Drug-resistant tuberculosis Levofloxacin - pharmacology Levofloxacin - therapeutic use Mice Mice, Inbred BALB C Mice, SCID Mycobacterium bovis - chemistry Mycobacterium bovis - drug effects Mycobacterium bovis - genetics Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - pathogenicity Plasmids Prothionamide - pharmacology Prothionamide - therapeutic use Pyrazinamide - pharmacology Pyrazinamide - therapeutic use Recombinant drug-resistant BCG Rv2628 Therapeutic vaccine Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - pathology Tuberculosis, Pulmonary - prevention & control Vaccines, Synthetic - biosynthesis Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vaccines, Synthetic - therapeutic use Virulence
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