Analysis of antimicrobial susceptibility testing methods and variables and in vitro activity of gepotidacin against urogenital Neisseria gonorrhoeae in men

•New antibiotics are needed to treat antibiotic-resistant N. gonorrhoeae infections.•Gepotidacin is a novel triazaacenaphthylene antibiotic.•Gepotidacin demonstrated activity against N. gonorrhoeae isolates in vitro.•Media type, inoculum, CO2, and pH can impact MIC testing with gepotidacin. Gepotida...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 2021-12, Vol.101 (4), p.115484-115484, Article 115484
Hauptverfasser:	Scangarella-Oman, Nicole E., Dixon, Paula, Koeth, Laura M., DiFranco-Fisher, Jeanna, Miller, Linda A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acenaphthenes - pharmacology Anti-Bacterial Agents - pharmacology antibacterial agent antimicrobial susceptibility testing Carbon Dioxide - analysis Culture Media Drug Resistance, Bacterial - drug effects gepotidacin Gonorrhea - microbiology GSK2140944 Heterocyclic Compounds, 3-Ring - pharmacology Humans Hydrogen-Ion Concentration Male Microbial Sensitivity Tests - instrumentation Microbial Sensitivity Tests - methods minimum inhibitory concentration N. gonorrhoeae Neisseria gonorrhoeae - drug effects Neisseria gonorrhoeae - isolation & purification
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