Paeoniflorin Suppresses Rheumatoid Arthritis Development via Modulating the Circ-FAM120A/miR-671-5p/MDM4 Axis
Paeoniflorin is an active ingredient derived from Paeonia, which has an anti-inflammatory effect. However, the potential role and basis of paeoniflorin in rheumatoid arthritis (RA) are indistinct. Cell viability, cycle distribution, migration, and invasion were evaluated via Cell Counting Kit-8 (CCK...
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| Veröffentlicht in: | Inflammation 2021-12, Vol.44 (6), p.2309-2322 |
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| creator | Ma, Junfu Meng, Qingliang Zhan, Junping Wang, Huilian Fan, Wei Wang, Yanqi Zhang, Sudan Bian, Hua Zheng, Fuzeng |
| description | Paeoniflorin is an active ingredient derived from Paeonia, which has an anti-inflammatory effect. However, the potential role and basis of paeoniflorin in rheumatoid arthritis (RA) are indistinct. Cell viability, cycle distribution, migration, and invasion were evaluated via Cell Counting Kit-8 (CCK-8), flow cytometry, and transwell assays. The contents of inflammatory cytokines were examined using enzyme-linked immunosorbent assay (ELISA). RNA expression levels were determined via qRT-PCR and western blot. The targeting relationship between miR-671-5p and circ-FAM120A (hsa_circ_0003972) or murine double minute 4 (MDM4) was validated via dual-luciferase reporter assay. Paeoniflorin restrained proliferation, migration, invasion, and inflammation and accelerated cell cycle arrest in RA fibroblast–like synoviocytes (RA-FLSs). Circ-FAM120A was boosted in RA synovial tissues and RA-FLSs. Circ-FAM120A upregulation, miR-671-5p knockdown, or MDM4 augmentation reversed the repressive effect of paeoniflorin on RA-FLS progression. Moreover, paeoniflorin attenuated RA-FLS progression by regulating the circ-FAM120A/miR-671-5p/MDM4 axis. Paeoniflorin inhibited RA-FLS proliferation, mobility, and inflammation and triggered cell cycle arrest via mediating the circ-FAM120A/miR-671-5p/MDM4 pathway. |
| doi_str_mv | 10.1007/s10753-021-01504-0 |
| format | Article |
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However, the potential role and basis of paeoniflorin in rheumatoid arthritis (RA) are indistinct. Cell viability, cycle distribution, migration, and invasion were evaluated via Cell Counting Kit-8 (CCK-8), flow cytometry, and transwell assays. The contents of inflammatory cytokines were examined using enzyme-linked immunosorbent assay (ELISA). RNA expression levels were determined via qRT-PCR and western blot. The targeting relationship between miR-671-5p and circ-FAM120A (hsa_circ_0003972) or murine double minute 4 (MDM4) was validated via dual-luciferase reporter assay. Paeoniflorin restrained proliferation, migration, invasion, and inflammation and accelerated cell cycle arrest in RA fibroblast–like synoviocytes (RA-FLSs). Circ-FAM120A was boosted in RA synovial tissues and RA-FLSs. Circ-FAM120A upregulation, miR-671-5p knockdown, or MDM4 augmentation reversed the repressive effect of paeoniflorin on RA-FLS progression. Moreover, paeoniflorin attenuated RA-FLS progression by regulating the circ-FAM120A/miR-671-5p/MDM4 axis. Paeoniflorin inhibited RA-FLS proliferation, mobility, and inflammation and triggered cell cycle arrest via mediating the circ-FAM120A/miR-671-5p/MDM4 pathway.</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/s10753-021-01504-0</identifier><identifier>PMID: 34423389</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Anti-Inflammatory Agents - pharmacology ; Antirheumatic Agents - pharmacology ; Arthritis, Rheumatoid - drug therapy ; Arthritis, Rheumatoid - genetics ; Arthritis, Rheumatoid - metabolism ; Arthritis, Rheumatoid - pathology ; Biomedical and Life Sciences ; Biomedicine ; Case-Control Studies ; Cell cycle ; Cell Cycle Checkpoints - drug effects ; Cell Cycle Proteins - genetics ; Cell Cycle Proteins - metabolism ; Cell migration ; Cell Movement - drug effects ; Cell Proliferation - drug effects ; Cell viability ; Cells, Cultured ; Cholecystokinin ; Cytokines ; Cytokines - metabolism ; Enzyme-linked immunosorbent assay ; Fibroblasts - drug effects ; Fibroblasts - metabolism ; Fibroblasts - pathology ; Flow cytometry ; Glucosides - pharmacology ; Humans ; Immunology ; Inflammation ; Inflammation Mediators - metabolism ; Internal Medicine ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Monoterpenes - pharmacology ; Original Article ; Pathology ; Pharmacology/Toxicology ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins - metabolism ; Rheumatoid arthritis ; Rheumatology ; RNA, Circular - genetics ; RNA, Circular - metabolism ; Signal Transduction ; Synoviocytes ; Synoviocytes - drug effects ; Synoviocytes - metabolism ; Synoviocytes - pathology</subject><ispartof>Inflammation, 2021-12, Vol.44 (6), p.2309-2322</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-24b23bf59e6161a51890ff96d267d67481c37a9b2454faae5fb9cb6fd798959f3</citedby><cites>FETCH-LOGICAL-c375t-24b23bf59e6161a51890ff96d267d67481c37a9b2454faae5fb9cb6fd798959f3</cites><orcidid>0000-0002-9746-2134</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10753-021-01504-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10753-021-01504-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34423389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Junfu</creatorcontrib><creatorcontrib>Meng, Qingliang</creatorcontrib><creatorcontrib>Zhan, Junping</creatorcontrib><creatorcontrib>Wang, Huilian</creatorcontrib><creatorcontrib>Fan, Wei</creatorcontrib><creatorcontrib>Wang, Yanqi</creatorcontrib><creatorcontrib>Zhang, Sudan</creatorcontrib><creatorcontrib>Bian, Hua</creatorcontrib><creatorcontrib>Zheng, Fuzeng</creatorcontrib><title>Paeoniflorin Suppresses Rheumatoid Arthritis Development via Modulating the Circ-FAM120A/miR-671-5p/MDM4 Axis</title><title>Inflammation</title><addtitle>Inflammation</addtitle><addtitle>Inflammation</addtitle><description>Paeoniflorin is an active ingredient derived from Paeonia, which has an anti-inflammatory effect. However, the potential role and basis of paeoniflorin in rheumatoid arthritis (RA) are indistinct. Cell viability, cycle distribution, migration, and invasion were evaluated via Cell Counting Kit-8 (CCK-8), flow cytometry, and transwell assays. The contents of inflammatory cytokines were examined using enzyme-linked immunosorbent assay (ELISA). RNA expression levels were determined via qRT-PCR and western blot. The targeting relationship between miR-671-5p and circ-FAM120A (hsa_circ_0003972) or murine double minute 4 (MDM4) was validated via dual-luciferase reporter assay. Paeoniflorin restrained proliferation, migration, invasion, and inflammation and accelerated cell cycle arrest in RA fibroblast–like synoviocytes (RA-FLSs). Circ-FAM120A was boosted in RA synovial tissues and RA-FLSs. Circ-FAM120A upregulation, miR-671-5p knockdown, or MDM4 augmentation reversed the repressive effect of paeoniflorin on RA-FLS progression. Moreover, paeoniflorin attenuated RA-FLS progression by regulating the circ-FAM120A/miR-671-5p/MDM4 axis. Paeoniflorin inhibited RA-FLS proliferation, mobility, and inflammation and triggered cell cycle arrest via mediating the circ-FAM120A/miR-671-5p/MDM4 pathway.</description><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antirheumatic Agents - pharmacology</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Arthritis, Rheumatoid - genetics</subject><subject>Arthritis, Rheumatoid - metabolism</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Case-Control Studies</subject><subject>Cell cycle</subject><subject>Cell Cycle Checkpoints - drug effects</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cell migration</subject><subject>Cell Movement - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell viability</subject><subject>Cells, Cultured</subject><subject>Cholecystokinin</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Fibroblasts - drug effects</subject><subject>Fibroblasts - metabolism</subject><subject>Fibroblasts - pathology</subject><subject>Flow cytometry</subject><subject>Glucosides - pharmacology</subject><subject>Humans</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>Inflammation Mediators - metabolism</subject><subject>Internal Medicine</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Monoterpenes - pharmacology</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Pharmacology/Toxicology</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatology</subject><subject>RNA, Circular - genetics</subject><subject>RNA, Circular - metabolism</subject><subject>Signal Transduction</subject><subject>Synoviocytes</subject><subject>Synoviocytes - 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Academic</collection><jtitle>Inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Junfu</au><au>Meng, Qingliang</au><au>Zhan, Junping</au><au>Wang, Huilian</au><au>Fan, Wei</au><au>Wang, Yanqi</au><au>Zhang, Sudan</au><au>Bian, Hua</au><au>Zheng, Fuzeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paeoniflorin Suppresses Rheumatoid Arthritis Development via Modulating the Circ-FAM120A/miR-671-5p/MDM4 Axis</atitle><jtitle>Inflammation</jtitle><stitle>Inflammation</stitle><addtitle>Inflammation</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>44</volume><issue>6</issue><spage>2309</spage><epage>2322</epage><pages>2309-2322</pages><issn>0360-3997</issn><eissn>1573-2576</eissn><abstract>Paeoniflorin is an active ingredient derived from Paeonia, which has an anti-inflammatory effect. However, the potential role and basis of paeoniflorin in rheumatoid arthritis (RA) are indistinct. Cell viability, cycle distribution, migration, and invasion were evaluated via Cell Counting Kit-8 (CCK-8), flow cytometry, and transwell assays. The contents of inflammatory cytokines were examined using enzyme-linked immunosorbent assay (ELISA). RNA expression levels were determined via qRT-PCR and western blot. The targeting relationship between miR-671-5p and circ-FAM120A (hsa_circ_0003972) or murine double minute 4 (MDM4) was validated via dual-luciferase reporter assay. Paeoniflorin restrained proliferation, migration, invasion, and inflammation and accelerated cell cycle arrest in RA fibroblast–like synoviocytes (RA-FLSs). Circ-FAM120A was boosted in RA synovial tissues and RA-FLSs. Circ-FAM120A upregulation, miR-671-5p knockdown, or MDM4 augmentation reversed the repressive effect of paeoniflorin on RA-FLS progression. Moreover, paeoniflorin attenuated RA-FLS progression by regulating the circ-FAM120A/miR-671-5p/MDM4 axis. Paeoniflorin inhibited RA-FLS proliferation, mobility, and inflammation and triggered cell cycle arrest via mediating the circ-FAM120A/miR-671-5p/MDM4 pathway.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34423389</pmid><doi>10.1007/s10753-021-01504-0</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-9746-2134</orcidid></addata></record> |
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| subjects | Anti-Inflammatory Agents - pharmacology Antirheumatic Agents - pharmacology Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Biomedical and Life Sciences Biomedicine Case-Control Studies Cell cycle Cell Cycle Checkpoints - drug effects Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell migration Cell Movement - drug effects Cell Proliferation - drug effects Cell viability Cells, Cultured Cholecystokinin Cytokines Cytokines - metabolism Enzyme-linked immunosorbent assay Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Flow cytometry Glucosides - pharmacology Humans Immunology Inflammation Inflammation Mediators - metabolism Internal Medicine MicroRNAs - genetics MicroRNAs - metabolism Monoterpenes - pharmacology Original Article Pathology Pharmacology/Toxicology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Rheumatoid arthritis Rheumatology RNA, Circular - genetics RNA, Circular - metabolism Signal Transduction Synoviocytes Synoviocytes - drug effects Synoviocytes - metabolism Synoviocytes - pathology |
| title | Paeoniflorin Suppresses Rheumatoid Arthritis Development via Modulating the Circ-FAM120A/miR-671-5p/MDM4 Axis |
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